product summary
Loading...
company name :
R&D Systems
product type :
antibody
product name :
Human IFN-gamma Antibody
catalog :
MAB285-100
quantity :
100 ug (also 25 ug, 500 ug)
price :
499 USD
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
25718
reactivity :
human
application :
ELISA, immunohistochemistry, immunocytochemistry, neutralization, flow cytometry, immunohistochemistry - frozen section
more info or order :
citations: 45
Reference
Moore G, Zeng V, Diaz J, Bonzon C, Avery K, Rashid R, et al. A B7-H3-targeted CD28 bispecific antibody enhances the activity of anti-PD1 and CD3 T-cell engager immunotherapies. Mol Cancer Ther. 2024;: pubmed publisher
Law C, Wacleche V, Cao Y, Pillai A, Sowerby J, Hancock B, et al. Interferon subverts an AHR-JUN axis to promote CXCL13+ T cells in lupus. Nature. 2024;631:857-866 pubmed publisher
Wu S, Dai X, Xia Y, Zhao Q, Zhao H, Shi Z, et al. Targeting high circDNA2v levels in colorectal cancer induces cellular senescence and elicits an anti-tumor secretome. Cell Rep. 2024;43:114111 pubmed publisher
Aquino Y, Bisiaux A, Li Z, O Neill M, Mendoza Revilla J, Merkling S, et al. Dissecting human population variation in single-cell responses to SARS-CoV-2. Nature. 2023;621:120-128 pubmed publisher
King L, Toffoli E, Veth M, Iglesias Guimarais V, Slot M, Amsen D, et al. A bispecific γδ T-cell engager targeting EGFR activates a potent Vγ9Vδ2 T cell-mediated immune response against EGFR-expressing tumors. Cancer Immunol Res. 2023;: pubmed publisher
Laufer Britva R, Keren A, Bertolini M, Ullmann Y, Paus R, Gilhar A. Involvement of ILC1-like innate lymphocytes in human autoimmunity, lessons from alopecia areata. elife. 2023;12: pubmed publisher
Rode A, Buus T, Mraz V, Al Jaberi F, Lopez D, Ford S, et al. Induced Human Regulatory T Cells Express the Glucagon-like Peptide-1 Receptor. Cells. 2022;11: pubmed publisher
Goyal G, Prabhala P, Mahajan G, Bausk B, Gilboa T, Xie L, et al. Ectopic Lymphoid Follicle Formation and Human Seasonal Influenza Vaccination Responses Recapitulated in an Organ-on-a-Chip. Adv Sci (Weinh). 2022;9:e2103241 pubmed publisher
Li J, Cheng L, Jia H, Liu C, Wang S, Liu Y, et al. IFN-γ facilitates liver fibrogenesis by CD161+CD4+ T cells through a regenerative IL-23/IL-17 axis in chronic hepatitis B virus infection. Clin Transl Immunology. 2021;10:e1353 pubmed publisher
Smith N, Goncalves P, Charbit B, Grzelak L, Beretta M, Planchais C, et al. Distinct systemic and mucosal immune responses during acute SARS-CoV-2 infection. Nat Immunol. 2021;22:1428-1439 pubmed publisher
Hu Q, Liao P, Li W, Hu J, Chen C, Zhang Y, et al. Clinical Use of Propranolol Reduces Biomarkers of Proliferation in Gastric Cancer. Front Oncol. 2021;11:628613 pubmed publisher
Xing Y, Cai J, Qin J, Zhou W, Li C, Li X. Expansion of Monocytic Myeloid-Derived Suppressor Cells in Patients Under Hemodialysis Might Lead to Cardiovascular and Cerebrovascular Events. Front Immunol. 2020;11:577253 pubmed publisher
Ma F, Hao H, Gao X, Cai Y, Zhou J, Liang P, et al. Melatonin ameliorates necrotizing enterocolitis by preventing Th17/Treg imbalance through activation of the AMPK/SIRT1 pathway. Theranostics. 2020;10:7730-7746 pubmed publisher
Haug V, Kollar B, Tasigiorgos S, Endo Y, Kauke M, Safi A, et al. Hypothermic Ex Situ Perfusion of Human Limbs With Acellular Solution for 24 Hours. Transplantation. 2020;104:e260-e270 pubmed publisher
Schilbach K, Welker C, Krickeberg N, Kai xdf er C, Schleicher S, Hashimoto H. In the Absence of a TCR Signal IL-2/IL-12/18-Stimulated γδ T Cells Demonstrate Potent Anti-Tumoral Function Through Direct Killing and Senescence Induction in Cancer Cells. Cancers (Basel). 2020;12: pubmed publisher
Szabo P, Levitin H, Miron M, Snyder M, Senda T, Yuan J, et al. Single-cell transcriptomics of human T cells reveals tissue and activation signatures in health and disease. Nat Commun. 2019;10:4706 pubmed publisher
Baruah P, Bullenkamp J, Wilson P, Lee M, Kaski J, Dumitriu I. TLR9 Mediated Tumor-Stroma Interactions in Human Papilloma Virus (HPV)-Positive Head and Neck Squamous Cell Carcinoma Up-Regulate PD-L1 and PD-L2. Front Immunol. 2019;10:1644 pubmed publisher
Kallionp xe4 xe4 H, Somani J, Tuomela S, Ullah U, de Albuquerque R, L xf6 nnberg T, et al. Early Detection of Peripheral Blood Cell Signature in Children Developing β-Cell Autoimmunity at a Young Age. Diabetes. 2019;68:2024-2034 pubmed publisher
Duarte Neto A, Croda J, Pagliari C, Soriano F, Nicodemo A, Duarte M. Severe Leptospirosis Features in the Spleen Indicate Cellular Immunosuppression Similar to That Found in Septic Shock. Front Immunol. 2019;10:920 pubmed publisher
Frascoli M, Coniglio L, Witt R, Jeanty C, Fleck Derderian S, Myers D, et al. Alloreactive fetal T cells promote uterine contractility in preterm labor via IFN-γ and TNF-α. Sci Transl Med. 2018;10: pubmed publisher
Zhang F, Liu G, Li D, Wei C, Hao J. DDIT4 and Associated lncDDIT4 Modulate Th17 Differentiation through the DDIT4/TSC/mTOR Pathway. J Immunol. 2018;200:1618-1626 pubmed publisher
Liu Y, Qu L, Liu Y, Roizman B, Zhou G. PUM1 is a biphasic negative regulator of innate immunity genes by suppressing LGP2. Proc Natl Acad Sci U S A. 2017;114:E6902-E6911 pubmed publisher
Longhi M, Vuerich M, Kalbasi A, Kenison J, Yeste A, Csizmadia E, et al. Bilirubin suppresses Th17 immunity in colitis by upregulating CD39. JCI Insight. 2017;2: pubmed publisher
Paquin Proulx D, Gibbs A, Bachle S, Checa A, Introini A, Leeansyah E, et al. Innate Invariant NKT Cell Recognition of HIV-1-Infected Dendritic Cells Is an Early Detection Mechanism Targeted by Viral Immune Evasion. J Immunol. 2016;197:1843-51 pubmed publisher
Schiavano G, Dominici S, Rinaldi L, Cangiano A, Brandi G, Magnani M. Modulation of Stat-1 in Human Macrophages Infected with Different Species of Intracellular Pathogenic Bacteria. J Immunol Res. 2016;2016:5086928 pubmed publisher
Arterbery A, Osafo Addo A, Avitzur Y, Ciarleglio M, Deng Y, Lobritto S, et al. Production of Proinflammatory Cytokines by Monocytes in Liver-Transplanted Recipients with De Novo Autoimmune Hepatitis Is Enhanced and Induces TH1-like Regulatory T Cells. J Immunol. 2016;196:4040-51 pubmed publisher
Zhong F, Zhou N, Wu K, Guo Y, Tan W, Zhang H, et al. A SnoRNA-derived piRNA interacts with human interleukin-4 pre-mRNA and induces its decay in nuclear exosomes. Nucleic Acids Res. 2015;43:10474-91 pubmed publisher
Ranzani V, Rossetti G, Panzeri I, Arrigoni A, Bonnal R, Curti S, et al. The long intergenic noncoding RNA landscape of human lymphocytes highlights the regulation of T cell differentiation by linc-MAF-4. Nat Immunol. 2015;16:318-325 pubmed publisher
Kongsbak M, von Essen M, Boding L, Levring T, Schjerling P, Lauritsen J, et al. Vitamin D up-regulates the vitamin D receptor by protecting it from proteasomal degradation in human CD4+ T cells. PLoS ONE. 2014;9:e96695 pubmed publisher
Alcantar Orozco E, Gornall H, Baldan V, Hawkins R, Gilham D. Potential limitations of the NSG humanized mouse as a model system to optimize engineered human T cell therapy for cancer. Hum Gene Ther Methods. 2013;24:310-20 pubmed publisher
Flynn J, Dore G, Hellard M, Yeung B, Rawlinson W, White P, et al. Maintenance of Th1 hepatitis C virus (HCV)-specific responses in individuals with acute HCV who achieve sustained virological clearance after treatment. J Gastroenterol Hepatol. 2013;28:1770-81 pubmed publisher
Capelozzi V, Parra E, Ximenes M, Bammann R, Barbas C, Duarte M. Pathological and ultrastructural analysis of surgical lung biopsies in patients with swine-origin influenza type A/H1N1 and acute respiratory failure. Clinics (Sao Paulo). 2010;65:1229-37 pubmed
Chang H, Sehra S, Goswami R, Yao W, Yu Q, Stritesky G, et al. The transcription factor PU.1 is required for the development of IL-9-producing T cells and allergic inflammation. Nat Immunol. 2010;11:527-34 pubmed publisher
R Viso A, Duarte M, Pagliari C, Fernandes E, Brasil R, Benard G, et al. Tissue and serum immune response in chronic hepatitis C with mild histological lesions. Mem Inst Oswaldo Cruz. 2010;105:25-32 pubmed
Reiss A, Anwar K, Merrill J, Chan E, Awadallah N, Cronstein B, et al. Plasma from systemic lupus patients compromises cholesterol homeostasis: a potential mechanism linking autoimmunity to atherosclerotic cardiovascular disease. Rheumatol Int. 2010;30:591-8 pubmed publisher
Chang H, Han L, Goswami R, Nguyen E, Pelloso D, Robertson M, et al. Impaired development of human Th1 cells in patients with deficient expression of STAT4. Blood. 2009;113:5887-90 pubmed publisher
Seshasayee D, Lee W, Zhou M, Shu J, Suto E, Zhang J, et al. In vivo blockade of OX40 ligand inhibits thymic stromal lymphopoietin driven atopic inflammation. J Clin Invest. 2007;117:3868-78 pubmed
Pontikoglou C, Liapakis G, Pyrovolaki K, Papadakis M, Bux J, Eliopoulos G, et al. Evidence for downregulation of erythropoietin receptor in bone marrow erythroid cells of patients with chronic idiopathic neutropenia. Exp Hematol. 2006;34:1312-22 pubmed
Ebert E, Mehta V. Human intestinal intraepithelial lymphocytes keep TNF alpha levels low by cell uptake and feedback inhibition of transcription. Cell Immunol. 2006;241:7-13 pubmed
Methe H, Wiegand D, Welsch U, Krombach F, Meiser B, Nabauer M, et al. Peripheral expansion of circulating T-helper 1 cells predicts coronary endothelial dysfunction after cardiac transplantation. J Heart Lung Transplant. 2005;24:833-40 pubmed
Miranda Carús M, Balsa A, Benito Miguel M, Pérez de Ayala C, Martin Mola E. IL-15 and the initiation of cell contact-dependent synovial fibroblast-T lymphocyte cross-talk in rheumatoid arthritis: effect of methotrexate. J Immunol. 2004;173:1463-76 pubmed
Herrero C, Hu X, Li W, Samuels S, Sharif M, Kotenko S, et al. Reprogramming of IL-10 activity and signaling by IFN-gamma. J Immunol. 2003;171:5034-41 pubmed
Durali D, de Goër de Herve M, Giron Michel J, Azzarone B, Delfraissy J, Taoufik Y. In human B cells, IL-12 triggers a cascade of molecular events similar to Th1 commitment. Blood. 2003;102:4084-9 pubmed
Wolk K, Kunz S, Asadullah K, Sabat R. Cutting edge: immune cells as sources and targets of the IL-10 family members?. J Immunol. 2002;168:5397-402 pubmed
Ong P, Hamid Q, Travers J, Strickland I, Al Kerithy M, Boguniewicz M, et al. Decreased IL-15 may contribute to elevated IgE and acute inflammation in atopic dermatitis. J Immunol. 2002;168:505-10 pubmed
product information
brand :
R&D Systems
master code :
MAB285
SKU :
MAB285-100
product name :
Human IFN-gamma Antibody
unit size :
100 ug (also 25 ug, 500 ug)
seo description :
The Human IFN-gamma Antibody from R&D Systems is a mouse monoclonal antibody to IFN-gamma. This antibody reacts with human. The Human IFN-gamma Antibody has been validated for the following applications: Neutralization,Immunohistochemistry,Differentiation,Luminex (Detection),Stimulation,Flow Cytometry,Functional Assay,ELISA Detection,Immunohistochemistry-Frozen,Intracellular Staining by Flow Cytometry,Immunocytochemistry.
target :
IFN-gamma
category :
Primary Antibodies
buffer :
Lyophilized from a 0.2 ╡m filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 ╡m filtered solution in PBS.
clonality :
Monoclonal
clone :
25718
conjugate :
Unconjugated
dilution :
Neutralization 0.02-0.06 ug/mL, Intracellular Staining by Flow Cytometry 0.25 ug/10^6 cells, Immunocytochemistry 8-25 ug/mL
host :
Mouse
immunogen :
E. coli -derived recombinant human IFN-gamma , Gln24-Gln166, Accession # AAP20098.1
isotype :
IgG2a
purity :
Protein A or G purified from hybridoma culture supernatant
species :
Human
specificity :
Detects human IFN-gamma .
gene symbol :
IFNG
endotoxin note :
<0.10 EU per 1 ╡g of the antibody by the LAL method.
top caption :
IFN-? antibody in Human PBMCs by Immunocytochemistry (ICC).
accessionNumbers :
AAP20098.1
applications :
Intracellular Staining by Flow Cytometry,Immunocytochemistry,Differentiation,Luminex (Detection),Stimulation,Flow Cytometry,Immunohistochemistry,Immunohistochemistry-Frozen,Neutralization,Functional Assay,ELISA Detection
USD :
499 USD
alt names :
IFG, IFI, IFNG, IFNgamma, IFN-gamma, Immune interferon, interferon gamma, interferon, gamma
storage :
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 6 months, -20 to -70 ░C under sterile conditions after reconstitution.
more info or order :
company information
R&D Systems
614 McKinley Place N.E.
Minneapolis, MN 55413
info@RnDSystems.com
https://www.rndsystems.com
800 343-7475
headquarters: USA
R&D Systems develops and manufactures high-quality proteins and serves as a world leader in immunoassays. R&D Systems also produces quality antibodies, antibody arrays, stem cell and cell culture products, and cell selection and detection products, serving the life science and diagnostics industry.