Oxidized PTP Active Site Antibody | R&D Systems MAB2844 product information

product summary

company name :

R&D Systems

product type :

antibody

product name :

Oxidized PTP Active Site Antibody

catalog :

MAB2844

quantity :

100 ug (also 25 ug)

price :

479 USD

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

335636

application :

western blot, neutralization, immunoprecipitation

more info or order :

R&D Systems product webpage

citations: 18

Reference
Cappabianca L, Ruggieri M, Sebastiano M, Sbaffone M, Martelli I, Ruggeri P, et al. Molecular Characterization and Inhibition of a Novel Stress-Induced Mitochondrial Protecting Role for Misfolded TrkAIII in Human SH-SY5Y Neuroblastoma Cells. Int J Mol Sci. 2024;25: pubmed publisher
Choi S, Lee J, Hatzihristidis T, Gaud G, Dutta A, Arya A, et al. THEMIS increases TCR signaling in CD4+CD8+ thymocytes by inhibiting the activity of the tyrosine phosphatase SHP1. Sci Signal. 2023;16:eade1274 pubmed publisher
Choi S, Hatzihristidis T, Gaud G, Dutta A, Lee J, Arya A, et al. GRB2 promotes thymocyte positive selection by facilitating THEMIS-mediated inactivation of SHP1. J Exp Med. 2023;220: pubmed publisher
Luong N, Abiko Y, Shibata T, Uchida K, Warabi E, Suzuki M, et al. Redox cycling of 9,10-phenanthrenequinone activates epidermal growth factor receptor signaling through S-oxidation of protein tyrosine phosphatase 1B. J Toxicol Sci. 2020;45:349-363 pubmed publisher
Liu J, Qu L, Meng L, Shou C. Topoisomerase inhibitors promote cancer cell motility via ROS-mediated activation of JAK2-STAT1-CXCL1 pathway. J Exp Clin Cancer Res. 2019;38:370 pubmed publisher
Duval R, Bui L, Mathieu C, Nian Q, Berthelet J, Xu X, et al. Benzoquinone, a leukemogenic metabolite of benzene, catalytically inhibits the protein tyrosine phosphatase PTPN2 and alters STAT1 signaling. J Biol Chem. 2019;294:12483-12494 pubmed publisher
Grohmann M, Wiede F, Dodd G, Gurzov E, Ooi G, Butt T, et al. Obesity Drives STAT-1-Dependent NASH and STAT-3-Dependent HCC. Cell. 2018;175:1289-1306.e20 pubmed publisher
Neves K, Montezano A, Alves Lopes R, Bruder Nascimento T, Costa R, Costa R, et al. Upregulation of Nrf2 and Decreased Redox Signaling Contribute to Renoprotective Effects of Chemerin Receptor Blockade in Diabetic Mice. Int J Mol Sci. 2018;19: pubmed publisher
Kim J, Park S, Chae U, Seong J, Lee H, Lee S, et al. Peroxiredoxin 2 mediates insulin sensitivity of skeletal muscles through regulation of protein tyrosine phosphatase oxidation. Int J Biochem Cell Biol. 2018;99:80-90 pubmed publisher
Choi S, Love P. Detection of Intracellular Reduced (Catalytically Active) SHP-1 and Analyses of Catalytically Inactive SHP-1 after Oxidation by Pervanadate or H2O2. Bio Protoc. 2018;8: pubmed publisher
Torii S, Kubota C, Saito N, Kawano A, Hou N, Kobayashi M, et al. The pseudophosphatase phogrin enables glucose-stimulated insulin signaling in pancreatic β cells. J Biol Chem. 2018;293:5920-5933 pubmed publisher
Wu W, Hale A, Lemeer S, den Hertog J. Differential oxidation of protein-tyrosine phosphatases during zebrafish caudal fin regeneration. Sci Rep. 2017;7:8460 pubmed publisher
Choi S, Warzecha C, Zvezdova E, Lee J, Argenty J, Lesourne R, et al. THEMIS enhances TCR signaling and enables positive selection by selective inhibition of the phosphatase SHP-1. Nat Immunol. 2017;18:433-441 pubmed publisher
Tong J, Helmy M, Cavalli F, Jin L, St Germain J, Karisch R, et al. Integrated analysis of proteome, phosphotyrosine-proteome, tyrosine-kinome, and tyrosine-phosphatome in acute myeloid leukemia. Proteomics. 2017;17: pubmed publisher
Karisch R, Fernandez M, Taylor P, Virtanen C, St Germain J, Jin L, et al. Global proteomic assessment of the classical protein-tyrosine phosphatome and "Redoxome". Cell. 2011;146:826-40 pubmed publisher
Hirakawa S, Saito R, Ohara H, Okuyama R, Aiba S. Dual oxidase 1 induced by Th2 cytokines promotes STAT6 phosphorylation via oxidative inactivation of protein tyrosine phosphatase 1B in human epidermal keratinocytes. J Immunol. 2011;186:4762-70 pubmed publisher
Sharma P, Chakraborty R, Wang L, Min B, Tremblay M, Kawahara T, et al. Redox regulation of interleukin-4 signaling. Immunity. 2008;29:551-64 pubmed publisher
Chen Y, Chu H, Pan K, Teng C, Wang D, Wang A, et al. Cysteine S-nitrosylation protects protein-tyrosine phosphatase 1B against oxidation-induced permanent inactivation. J Biol Chem. 2008;283:35265-72 pubmed publisher

product information

master code :

MAB2844

SKU :

MAB2844

product name :

Oxidized PTP Active Site Antibody

unit size :

100 ug (also 25 ug)

description :

The Oxidized PTP Active Site Antibody from R&D Systems is a mouse monoclonal antibody to Oxidized PTP Active Site. This antibody reacts with human,mouse,multi-species,fish - danio rerio (zebrafish). The Oxidized PTP Active Site Antibody has been validated for the following applications: Immunoprecipitation,Western Blot,Neutralization.

target :

Oxidized PTP Active Site

category :

Primary Antibodies

buffer :

Lyophilized from a 0.2 ╡m filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 ╡m filtered solution in PBS.

clonality :

Monoclonal

clone :

335636

concentration :

LYOPH

conjugate :

Unconjugated

host :

Mouse

immunogen :

KLH-coupled perfomic acid oxidized synthetic peptide, VHCSAG

isotype :

IgG1

purity :

Protein A or G purified from hybridoma culture supernatant

species :

Human,Mouse,Multi-Species,Fish - Danio rerio (Zebrafish)

specificity :

Detects Oxidized PTP Active Site. Will react with any oxidized phosphatase containing the consensus sequence. Detects oxidized but not unoxidized DEP-1, PTP1B, TC-PTP, and SHP-2. Other phosphatases have not been tested.

top caption :

Detection of Oxidized PTP antibody by Western Blot.

applications :

Western Blot,Immunoprecipitation,Neutralization

USD :

479 USD

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 6 months, -20 to -70 ░C under sterile conditions after reconstitution.

more info or order :

R&D Systems product webpage