product summary
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company name :
R&D Systems
product type :
antibody
product name :
Human IL-1ra/IL-1F3 Antibody
catalog :
MAB280
quantity :
1 mg (also 25 ug)
price :
539 USD
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
10309
reactivity :
human
application :
ELISA, immunocytochemistry, neutralization
more info or order :
R&D Systems product webpage
citations: 7
Reference
Hook J, Cao M, Weng K, Kinnare N, Moreland J. Mycobacterium tuberculosis Lipoarabinomannan Activates Human Neutrophils via a TLR2/1 Mechanism Distinct from Pam3CSK4. J Immunol. 2020;204:671-681 pubmed publisher
Dietrich D, Martin P, Flacher V, Sun Y, Jarrossay D, Brembilla N, et al. Interleukin-36 potently stimulates human M2 macrophages, Langerhans cells and keratinocytes to produce pro-inflammatory cytokines. Cytokine. 2016;84:88-98 pubmed publisher
Subang M, Fatah R, Bright C, Blanco P, Berenstein M, Wu Y, et al. A novel hybrid promoter responsive to pathophysiological and pharmacological regulation. J Mol Med (Berl). 2012;90:401-11 pubmed publisher
Kalliolias G, Gordon R, Ivashkiv L. Suppression of TNF-? and IL-1 signaling identifies a mechanism of homeostatic regulation of macrophages by IL-27. J Immunol. 2010;185:7047-56 pubmed publisher
Palmer G, Trolliet S, Talabot Ayer D, Mezin F, Magne D, Gabay C. Pre-interleukin-1alpha expression reduces cell growth and increases interleukin-6 production in SaOS-2 osteosarcoma cells: Differential inhibitory effect of interleukin-1 receptor antagonist (icIL-1Ra1). Cytokine. 2005;31:153-60 pubmed
Mozaffarian D, Rimm E, King I, Lawler R, McDonald G, Levy W. trans fatty acids and systemic inflammation in heart failure. Am J Clin Nutr. 2004;80:1521-5 pubmed
Copeland S, Siddiqui J, Remick D. Direct comparison of traditional ELISAs and membrane protein arrays for detection and quantification of human cytokines. J Immunol Methods. 2004;284:99-106 pubmed
product information
master code :
MAB280
SKU :
MAB280
product name :
Human IL-1ra/IL-1F3 Antibody
unit size :
1 mg (also 25 ug)
description :
The Human IL-1ra/IL-1F3 Antibody from R&D Systems is a mouse monoclonal antibody to IL-1ra/IL-1F3/IL1RN. This antibody reacts with human. The Human IL-1ra/IL-1F3 Antibody has been validated for the following applications: ELISA Capture,Immunocytochemistry,Array Development,ELISA Development,Neutralization,ELISA Capture (Matched Antibody Pair).
target :
IL-1ra/IL-1F3
category :
Primary Antibodies
buffer :
Lyophilized from a 0.2 ╡m filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 ╡m filtered solution in PBS.
clonality :
Monoclonal
clone :
10309
concentration :
LYOPH
conjugate :
Unconjugated
host :
Mouse
immunogen :
E. coli -derived recombinant human IL-1ra/IL-1F3, Arg26-Glu177, Accession # P18510
isotype :
IgG2a
purity :
Protein A or G purified from ascites
species :
Human
specificity :
Detects human IL-1ra/IL-1F3 in ELISAs. In ELISAs, this antibody shows less than 0.2% cross-reactivity with recombinant mouse (rm) IL-1ra and no cross-reactivity with rhIL-1 alpha , rpIL-1 alpha , rmIL-1 alpha , rrIL-1 alpha , rhIL-1▀, rpIL-1▀, rmIL-1▀, rrIL-1▀, rhIL-1 RI, or rhIL-1 RII.
gene symbol :
IL1RN
endotoxin note :
<0.10 EU per 1 ╡g of the antibody by the LAL method.
top caption :
IL-1ra/IL-1F3 Inhibition of IL-1a/IL-1F1-dependent Cell Proliferation and Neutralization by Human IL-1ra/IL-1F3 Antibody.
accessionNumbers :
P18510
applications :
ELISA Capture,Immunocytochemistry,Array Development,ELISA Development,Neutralization,ELISA Capture (Matched Antibody Pair)
USD :
539 USD
alt names :
DIRA, ICIL-1RA, IL1F3, IL-1F3, IL-1ra, IL1RA, IL-1ra3, IL1RN, IL-1RN, interleukin 1 receptor antagonist, IRAP, MVCD4
storage :
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 6 months, -20 to -70 ░C under sterile conditions after reconstitution.
more info or order :
R&D Systems product webpage
company information
R&D Systems
614 McKinley Place N.E.
Minneapolis, MN 55413
info@RnDSystems.com
https://www.rndsystems.com
800 343-7475
headquarters: USA
R&D Systems develops and manufactures high-quality proteins and serves as a world leader in immunoassays. R&D Systems also produces quality antibodies, antibody arrays, stem cell and cell culture products, and cell selection and detection products, serving the life science and diagnostics industry.