product summary
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company name :
R&D Systems
product type :
antibody
product name :
Human CCL2/JE/MCP-1 Antibody
catalog :
MAB2791-100
quantity :
100 ug (also 25 ug, 500 ug)
price :
469 USD
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
23002
reactivity :
human, mouse
application :
immunohistochemistry, immunocytochemistry, immunohistochemistry - paraffin section, immunohistochemistry - frozen section
more info or order :
R&D Systems product webpage
citations: 21
Published Application/Species/Sample/DilutionReference
  • immunohistochemistry; human; 10 ug/ml; loading ...; fig 3j
Zimmer T, Broekaart D, Luinenburg M, Mijnsbergen C, Anink J, Sim N, et al. Balloon cells promote immune system activation in focal cortical dysplasia type 2b. Neuropathol Appl Neurobiol. 2021;47:826-839 pubmed publisher
  • immunohistochemistry; human; 1:100; loading ...; fig s14a
Choi Y, Kim Y, Oh S, Suh K, Kim Y, Lee G, et al. Senescent Tumor Cells Build a Cytokine Shield in Colorectal Cancer. Adv Sci (Weinh). 2021;8:2002497 pubmed publisher
Bruijn L, van den Akker B, van Rhijn C, Hamming J, Lindeman J. Extreme Diversity of the Human Vascular Mesenchymal Cell Landscape. J Am Heart Assoc. 2020;9:e017094 pubmed publisher
Arase H, Sugasawa N, Kawatani Y, Sugano M, Kurobe H, Fujimoto E, et al. Appropriate Surgical Treatment of Symptomatic Primary Varicose Veins Decreases Systemic Inflammatory Biomarkers. Ann Vasc Dis. 2019;12:367-371 pubmed publisher
Chen M, Reed R, Lane A. Chronic Inflammation Directs an Olfactory Stem Cell Functional Switch from Neuroregeneration to Immune Defense. Cell Stem Cell. 2019;25:501-513.e5 pubmed publisher
Jenkins B, Martini R, Hire R, Brown A, Bennett B, Brown I, et al. Atypical Chemokine Receptor 1 (DARC/ACKR1) in Breast Tumors Is Associated with Survival, Circulating Chemokines, Tumor-Infiltrating Immune Cells, and African Ancestry. Cancer Epidemiol Biomarkers Prev. 2019;28:690-700 pubmed publisher
Triulzi T, Forte L, Regondi V, Di Modica M, Ghirelli C, Carcangiu M, et al. HER2 signaling regulates the tumor immune microenvironment and trastuzumab efficacy. Oncoimmunology. 2019;8:e1512942 pubmed publisher
Han R, Gu S, Zhang Y, Luo A, Jing X, Zhao L, et al. Estrogen promotes progression of hormone-dependent breast cancer through CCL2-CCR2 axis by upregulation of Twist via PI3K/AKT/NF-?B signaling. Sci Rep. 2018;8:9575 pubmed publisher
Deng X, Zou W, Xiong M, Wang Z, Engelhardt J, Ye S, et al. Human Parvovirus Infection of Human Airway Epithelia Induces Pyroptotic Cell Death by Inhibiting Apoptosis. J Virol. 2017;91: pubmed publisher
Rump L, Mattey D, Kehoe O, Middleton J. An initial investigation into endothelial CC chemokine expression in the human rheumatoid synovium. Cytokine. 2017;97:133-140 pubmed publisher
Hartlage Rübsamen M, Waniek A, Meissner J, Morawski M, Schilling S, Jäger C, et al. Isoglutaminyl cyclase contributes to CCL2-driven neuroinflammation in Alzheimer's disease. Acta Neuropathol. 2015;129:565-83 pubmed publisher
Bonapace L, Coissieux M, Wyckoff J, Mertz K, Varga Z, Junt T, et al. Cessation of CCL2 inhibition accelerates breast cancer metastasis by promoting angiogenesis. Nature. 2014;515:130-3 pubmed publisher
Prins M, Dutta R, Baselmans B, Brevé J, Bol J, Deckard S, et al. Discrepancy in CCL2 and CCR2 expression in white versus grey matter hippocampal lesions of Multiple Sclerosis patients. Acta Neuropathol Commun. 2014;2:98 pubmed publisher
Assassi S, Wu M, Tan F, Chang J, Graham T, Furst D, et al. Skin gene expression correlates of severity of interstitial lung disease in systemic sclerosis. Arthritis Rheum. 2013;65:2917-27 pubmed publisher
Zhang K, Waxman D. Impact of tumor vascularity on responsiveness to antiangiogenesis in a prostate cancer stem cell-derived tumor model. Mol Cancer Ther. 2013;12:787-98 pubmed publisher
Kitaya K, Yasuo T. Aberrant expression of selectin E, CXCL1, and CXCL13 in chronic endometritis. Mod Pathol. 2010;23:1136-46 pubmed publisher
Morrissey C, Lai J, Brown L, Wang Y, Roudier M, Coleman I, et al. The expression of osteoclastogenesis-associated factors and osteoblast response to osteolytic prostate cancer cells. Prostate. 2010;70:412-24 pubmed publisher
Weigt S, Elashoff R, Keane M, Strieter R, Gomperts B, Xue Y, et al. Altered levels of CC chemokines during pulmonary CMV predict BOS and mortality post-lung transplantation. Am J Transplant. 2008;8:1512-22 pubmed publisher
Schell C, Albrecht M, Mayer C, Schwarzer J, Frungieri M, Mayerhofer A. Exploring human testicular peritubular cells: identification of secretory products and regulation by tumor necrosis factor-alpha. Endocrinology. 2008;149:1678-86 pubmed publisher
Burt D, Salvidio G, Tarabra E, Barutta F, Pinach S, Dentelli P, et al. The monocyte chemoattractant protein-1/cognate CC chemokine receptor 2 system affects cell motility in cultured human podocytes. Am J Pathol. 2007;171:1789-99 pubmed
Pulliam L, Sun B, Rempel H. Invasive chronic inflammatory monocyte phenotype in subjects with high HIV-1 viral load. J Neuroimmunol. 2004;157:93-8 pubmed
product information
master code :
MAB2791
SKU :
MAB2791-100
product name :
Human CCL2/JE/MCP-1 Antibody
unit size :
100 ug (also 25 ug, 500 ug)
description :
The Human CCL2/JE/MCP-1 Antibody from R&D Systems is a mouse monoclonal antibody to CCL2/JE/MCP-1. This antibody reacts with human,mouse. The Human CCL2/JE/MCP-1 Antibody has been validated for the following applications: Immunohistochemistry,Immunohistochemistry-Paraffin,Immunohistochemistry-Frozen,Immunocytochemistry.
target :
CCL2/JE/MCP-1
category :
Primary Antibodies
buffer :
Lyophilized from a 0.2 ╡m filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 ╡m filtered solution in PBS.
clonality :
Monoclonal
clone :
23002
conjugate :
Unconjugated
host :
Mouse
immunogen :
E. coli -derived recombinant human CCL2/MCP-1, Gln24-Thr99, Accession # P13500
isotype :
IgG2b
purity :
Protein A or G purified from ascites
species :
Human,Mouse
specificity :
Detects human CCL2/JE/MCP-1 in ELISAs and Western blots. In ELISAs, does not cross-react with recombinant human CCL1, 3, 4, 5, 7, 8, 11, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, recombinant mouse CCL1, 2, 3, 4, 5, 6, 7, 9/10/MIP-1 gamma , 11, 12, 17, 19, 20, 21, 22, 24, 25, or recombinant rat CCL20.
gene symbol :
CCL2
top caption :
CCL2/JE/MCP-1 antibody in Human Breast Cancer Tissue by Immunohistochemistry (IHC-P).
accessionNumbers :
P13500
applications :
Immunohistochemistry,Immunohistochemistry-Paraffin,Immunohistochemistry-Frozen,Immunocytochemistry
USD :
469 USD
alt names :
C-C motif chemokine ligand 2, CCL2, GDCF-2, HC11, HSMCR30, MCAF, Mcp1, MCP-1, SCYA2, SMC-CF
storage :
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 6 months, -20 to -70 ░C under sterile conditions after reconstitution.
more info or order :
R&D Systems product webpage
company information
R&D Systems
614 McKinley Place N.E.
Minneapolis, MN 55413
info@RnDSystems.com
https://www.rndsystems.com
800 343-7475
headquarters: USA
R&D Systems develops and manufactures high-quality proteins and serves as a world leader in immunoassays. R&D Systems also produces quality antibodies, antibody arrays, stem cell and cell culture products, and cell selection and detection products, serving the life science and diagnostics industry.