Human CCL2/JE/MCP-1 Antibody | R&D Systems MAB279-100 product information

product summary

company name :

R&D Systems

product type :

antibody

product name :

Human CCL2/JE/MCP-1 Antibody

catalog :

MAB279-100

quantity :

100 ug (also 25 ug, 500 ug)

price :

469 USD

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

24822

reactivity :

human, mouse, rat

application :

western blot, immunocytochemistry, neutralization, flow cytometry, immunohistochemistry - paraffin section, immunohistochemistry - frozen section

more info or order :

R&D Systems product webpage

citations: 28

Reference
Yoshimura T, Li C, Wang Y, Matsukawa A. The chemokine monocyte chemoattractant protein-1/CCL2 is a promoter of breast cancer metastasis. Cell Mol Immunol. 2023;20:714-738 pubmed publisher
Cornelison R, Yuan J, Tate K, Petrosky A, Beeghly G, Bloomfield M, et al. A patient-designed tissue-engineered model of the infiltrative glioblastoma microenvironment. NPJ Precis Oncol. 2022;6:54 pubmed publisher
Wang L, Lan J, Tang J, Luo N. MCP-1 targeting: Shutting off an engine for tumor development. Oncol Lett. 2022;23:26 pubmed publisher
Hajal C, Shin Y, Li L, Serrano J, Jacks T, Kamm R. The CCL2-CCR2 astrocyte-cancer cell axis in tumor extravasation at the brain. Sci Adv. 2021;7: pubmed publisher
Gomez I, Ward B, Souilhol C, Recarti C, Ariaans M, Johnston J, et al. Neutrophil microvesicles drive atherosclerosis by delivering miR-155 to atheroprone endothelium. Nat Commun. 2020;11:214 pubmed publisher
Lai S, Liu Y, Lu D, Tsai C. Melatonin Modulates the Microenvironment of Glioblastoma Multiforme by Targeting Sirtuin 1. Nutrients. 2019;11: pubmed publisher
Cioni B, Nevedomskaya E, Melis M, van Burgsteden J, Stelloo S, Hodel E, et al. Loss of androgen receptor signaling in prostate cancer-associated fibroblasts (CAFs) promotes CCL2- and CXCL8-mediated cancer cell migration. Mol Oncol. 2018;12:1308-1323 pubmed publisher
Shen M, Chen Y, Xu L, Zhu R, Xue X, Tsai Y, et al. Increased infiltration of macrophages to radioresistant lung cancer cells contributes to the development of the additional resistance of tumor cells to the cytotoxic effects of NK cells. Int J Oncol. 2018;53:317-328 pubmed publisher
Li L, Liu Y, Zhan Y, Zhu Y, Li Y, Xie D, et al. High levels of CCL2 or CCL4 in the tumor microenvironment predict unfavorable survival in lung adenocarcinoma. Thorac Cancer. 2018;9:775-784 pubmed publisher
Liu C, Zhao Z, Chen Z, Che C, Zou Z, Wu X, et al. DL-3-n-butylphthalide protects endothelial cells against advanced glycation end product-induced injury by attenuating oxidative stress and inflammation responses. Exp Ther Med. 2017;14:2241-2248 pubmed publisher
Yao M, Smart C, Hu Q, Cheng N. Continuous Delivery of Neutralizing Antibodies Elevate CCL2 Levels in Mice Bearing MCF10CA1d Breast Tumor Xenografts. Transl Oncol. 2017;10:734-743 pubmed publisher
Vergani E, Di Guardo L, Dugo M, Rigoletto S, Tragni G, Ruggeri R, et al. Overcoming melanoma resistance to vemurafenib by targeting CCL2-induced miR-34a, miR-100 and miR-125b. Oncotarget. 2016;7:4428-41 pubmed publisher
Lindholm P, Sivapurapu N, Jovanovic B, Kajdacsy Balla A. Monocyte-Induced Prostate Cancer Cell Invasion is Mediated by Chemokine ligand 2 and Nuclear Factor-ÎºB Activity. J Clin Cell Immunol. 2015;6: pubmed
H xe5 rdstedt M, Lindblom S, Karlsson Parra A, Nilsson B, Korsgren O. Characterization of Innate Immunity in an Extended Whole Blood Model of Human Islet Allotransplantation. Cell Transplant. 2016;25:503-15 pubmed publisher
Mazumdar S, Arendt L, Phillips S, Sedic M, Kuperwasser C, Gill G. CoREST1 promotes tumor formation and tumor stroma interactions in a mouse model of breast cancer. PLoS ONE. 2015;10:e0121281 pubmed publisher
Matsubara K, Matsushita Y, Sakai K, Kano F, Kondo M, Noda M, et al. Secreted ectodomain of sialic acid-binding Ig-like lectin-9 and monocyte chemoattractant protein-1 promote recovery after rat spinal cord injury by altering macrophage polarity. J Neurosci. 2015;35:2452-64 pubmed publisher
Xu W, Joo H, Clayton S, Dullaers M, Herve M, Blankenship D, et al. Macrophages induce differentiation of plasma cells through CXCL10/IP-10. J Exp Med. 2012;209:1813-23, S1-2 pubmed
Fujita K, Ewing C, Getzenberg R, Parsons J, Isaacs W, Pavlovich C. Monocyte chemotactic protein-1 (MCP-1/CCL2) is associated with prostatic growth dysregulation and benign prostatic hyperplasia. Prostate. 2010;70:473-81 pubmed publisher
Dagouassat M, Suffee N, Hlawaty H, Haddad O, Charni F, Laguillier C, et al. Monocyte chemoattractant protein-1 (MCP-1)/CCL2 secreted by hepatic myofibroblasts promotes migration and invasion of human hepatoma cells. Int J Cancer. 2010;126:1095-108 pubmed publisher
Renaud S, Sullivan R, Graham C. Tumour necrosis factor alpha stimulates the production of monocyte chemoattractants by extravillous trophoblast cells via differential activation of MAPK pathways. Placenta. 2009;30:313-9 pubmed publisher
Huang S, Chen C, Schatz F, Rahman M, Abrahams V, Lockwood C. Pre-eclampsia is associated with dendritic cell recruitment into the uterine decidua. J Pathol. 2008;214:328-36 pubmed
Cheadle E, Riyad K, Subar D, Rothwell D, Ashton G, Batha H, et al. Eotaxin-2 and colorectal cancer: a potential target for immune therapy. Clin Cancer Res. 2007;13:5719-28 pubmed
Fischer J, West J, Agochukwu N, Suire C, Hale Donze H. Induction of host chemotactic response by Encephalitozoon spp. Infect Immun. 2007;75:1619-25 pubmed
Abe Y, Fornage M, Yang C, Bui Thanh N, Wise V, Chen H, et al. L5, the most electronegative subfraction of plasma LDL, induces endothelial vascular cell adhesion molecule 1 and CXC chemokines, which mediate mononuclear leukocyte adhesion. Atherosclerosis. 2007;192:56-66 pubmed
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product information

brand :

R&D Systems

master code :

MAB279

SKU :

MAB279-100

product name :

Human CCL2/JE/MCP-1 Antibody

unit size :

100 ug (also 25 ug, 500 ug)

seo description :

The Human CCL2/JE/MCP-1 Antibody from R&D Systems is a mouse monoclonal antibody to CCL2/JE/MCP-1. This antibody reacts with human,mouse,rat. The Human CCL2/JE/MCP-1 Antibody has been validated for the following applications: Bioassay,ELISA Development,Flow Cytometry,Neutralization,Immunohistochemistry-Paraffin,Immunohistochemistry-Frozen,Immunocytochemistry,Western Blot.

target :

CCL2/JE/MCP-1

category :

Primary Antibodies

buffer :

Lyophilized from a 0.2 ╡m filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 ╡m filtered solution in PBS.

clonality :

Monoclonal

clone :

24822

conjugate :

Unconjugated

dilution :

Western Blot 1 ug/mL, Neutralization 0.9-4.5 ug/mL

host :

Mouse

immunogen :

E. coli -derived recombinant human CCL2/JE/MCP-1

isotype :

IgG1

purity :

Protein A or G purified from ascites

species :

Human,Mouse,Rat

specificity :

Detects human CCL2/JE/MCP-1 in Western blots. Does not cross-react with recombinant human (rh) CCL1, 3, 4, 5, 7, 11, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, rmCCL1, 2, 3, 4, 5, 6, 7, 9/10MIP-1 gamma , 11, 12, 17, 19, 20, 22, 24, 25, or rrCCL20.

gene symbol :

CCL2

endotoxin note :

<0.10 EU per 1 ╡g of the antibody by the LAL method.

top caption :

Detection of Recombinant Human CCL2/JE/MCP-1 antibody by Western Blot.

applications :

Western Blot,Bioassay,ELISA Development,Flow Cytometry,Immunohistochemistry-Paraffin,Immunohistochemistry-Frozen,Neutralization,Immunocytochemistry

USD :

469 USD

alt names :

C-C motif chemokine ligand 2, CCL2, GDCF-2, HC11, HSMCR30, MCAF, Mcp1, MCP-1, SCYA2, SMC-CF

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 6 months, -20 to -70 ░C under sterile conditions after reconstitution.

more info or order :

R&D Systems product webpage