product summary
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company name :
R&D Systems
product type :
antibody
product name :
Human CCL5/RANTES Antibody
catalog :
MAB278-100
quantity :
100 ug (also 25 ug, 500 ug)
price :
459 USD
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
21445
reactivity :
human
application :
western blot, immunohistochemistry, immunocytochemistry, neutralization, flow cytometry, immunohistochemistry - paraffin section, immunohistochemistry - frozen section
more info or order :
R&D Systems product webpage
citations: 14
Published Application/Species/Sample/DilutionReference
  • immunohistochemistry; human; 1:100; loading ...; fig s14a
Choi Y, Kim Y, Oh S, Suh K, Kim Y, Lee G, et al. Senescent Tumor Cells Build a Cytokine Shield in Colorectal Cancer. Adv Sci (Weinh). 2021;8:2002497 pubmed publisher
Parween F, Singh S, Zhang H, Kathuria N, Otaizo Carrasquero F, Shamsaddini A, et al. Chemokine positioning determines mutually exclusive roles for their receptors in extravasation of pathogenic human T cells. bioRxiv. 2023;: pubmed publisher
Sullivan G, Galdi P, Borbye Lorenzen N, Stoye D, Lamb G, Evans M, et al. Preterm Birth Is Associated With Immune Dysregulation Which Persists in Infants Exposed to Histologic Chorioamnionitis. Front Immunol. 2021;12:722489 pubmed publisher
de Cubas A, Dunker W, Zaninovich A, Hongo R, Bhatia A, Panda A, et al. DNA hypomethylation promotes transposable element expression and activation of immune signaling in renal cell cancer. JCI Insight. 2020;5: pubmed publisher
Xu L, Li Z, Song S, Chen Q, Mo L, Wang C, et al. Downregulation of α-l-fucosidase 1 suppresses glioma progression by enhancing autophagy and inhibiting macrophage infiltration. Cancer Sci. 2020;111:2284-2296 pubmed publisher
Singh S, Mishra M, Rivers B, Gordetsky J, Bae S, Singh R. Biological and Clinical Significance of the CCR5/CCL5 Axis in Hepatocellular Carcinoma. Cancers (Basel). 2020;12: pubmed publisher
Nakajima N, Van Tin N, Sato Y, Thach H, Katano H, Diep P, et al. Pathological study of archival lung tissues from five fatal cases of avian H5N1 influenza in Vietnam. Mod Pathol. 2013;26:357-69 pubmed publisher
Scalley Kim M, Hess B, Kelly R, Krostag A, Lustig K, Marken J, et al. A novel highly potent therapeutic antibody neutralizes multiple human chemokines and mimics viral immune modulation. PLoS ONE. 2012;7:e43332 pubmed publisher
van Bladel E, Roest M, de Groot P, Schutgens R. Up-regulation of platelet activation in hemophilia A. Haematologica. 2011;96:888-95 pubmed publisher
Huang S, Chen C, Schatz F, Rahman M, Abrahams V, Lockwood C. Pre-eclampsia is associated with dendritic cell recruitment into the uterine decidua. J Pathol. 2008;214:328-36 pubmed
Bolovan Fritts C, Spector S. Endothelial damage from cytomegalovirus-specific host immune response can be prevented by targeted disruption of fractalkine-CX3CR1 interaction. Blood. 2008;111:175-82 pubmed
Haringman J, Smeets T, Reinders Blankert P, Tak P. Chemokine and chemokine receptor expression in paired peripheral blood mononuclear cells and synovial tissue of patients with rheumatoid arthritis, osteoarthritis, and reactive arthritis. Ann Rheum Dis. 2006;65:294-300 pubmed
Øynebråten I, Bakke O, Brandtzaeg P, Johansen F, Haraldsen G. Rapid chemokine secretion from endothelial cells originates from 2 distinct compartments. Blood. 2004;104:314-20 pubmed
Megjugorac N, Young H, Amrute S, Olshalsky S, Fitzgerald Bocarsly P. Virally stimulated plasmacytoid dendritic cells produce chemokines and induce migration of T and NK cells. J Leukoc Biol. 2004;75:504-14 pubmed
product information
brand :
R&D Systems
master code :
MAB278
SKU :
MAB278-100
product name :
Human CCL5/RANTES Antibody
unit size :
100 ug (also 25 ug, 500 ug)
seo description :
The Human CCL5/RANTES Antibody from R&D Systems is a mouse monoclonal antibody to CCL5/RANTES. This antibody reacts with human. The Human CCL5/RANTES Antibody has been validated for the following applications: ELISA Development,Flow Cytometry,Neutralization,Immunohistochemistry,Immunohistochemistry-Paraffin,Immunohistochemistry-Frozen,Immunocytochemistry,Western Blot,Intracellular Staining by Flow Cytometry,CyTOF-ready.
target :
CCL5/RANTES
category :
Primary Antibodies
buffer :
Lyophilized from a 0.2 ╡m filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 ╡m filtered solution in PBS.
clonality :
Monoclonal
clone :
21445
conjugate :
Unconjugated
dilution :
Western Blot 1 ug/mL, Immunohistochemistry 8-25 ug/mL, Neutralization 0.1-0.4 ug/mL, Intracellular Staining by Flow Cytometry 2.5 ug/10^6 cells, CyTOF-ready
host :
Mouse
immunogen :
E. coli -derived recombinant human CCL5/RANTES
isotype :
IgG1
purity :
Protein A or G purified from ascites
species :
Human
specificity :
Detects human CCL5/RANTES in direct ELISAs and Western blots. In direct ELISAs and Western blots, this antibody does not cross-react with other chemokines, including recombinant human CCL2, 3, 4, recombinant mouse (rm) CCL3, and rmCCL4.
gene symbol :
CCL5
endotoxin note :
<0.10 EU per 1 ╡g of the antibody by the LAL method.
top caption :
Chemotaxis Induced by CCL5/RANTES and Neutralization by Human CCL5/RANTES Antibody.
applications :
Western Blot,Intracellular Staining by Flow Cytometry,CyTOF-ready,ELISA Development,Flow Cytometry,Immunohistochemistry,Immunohistochemistry-Paraffin,Immunohistochemistry-Frozen,Neutralization,Immunocytochemistry
USD :
459 USD
alt names :
chemokine (C-C motif) ligand 5, D17S136Enormally T-expressed, and presumably secreted, EoCP, Eosinophil chemotactic cytokine, RANTES, SISd, SIS-delta, small inducible cytokine A5 (RANTES), small inducible cytokine subfamily A (Cys-Cys), member 5, Small-inducible cytokine A5, T cell-specific protein P228, T-cell specific protein p288, TCP228T-cell-specific protein RANTES
storage :
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 6 months, -20 to -70 ░C under sterile conditions after reconstitution.
more info or order :
R&D Systems product webpage
company information
R&D Systems
614 McKinley Place N.E.
Minneapolis, MN 55413
info@RnDSystems.com
https://www.rndsystems.com
800 343-7475
headquarters: USA
R&D Systems develops and manufactures high-quality proteins and serves as a world leader in immunoassays. R&D Systems also produces quality antibodies, antibody arrays, stem cell and cell culture products, and cell selection and detection products, serving the life science and diagnostics industry.