Human/Primate CXCL1/GRO alpha/KC/CINC-1 Antibody | R&D Systems MAB275 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

R&D Systems

product type :

antibody

product name :

Human/Primate CXCL1/GRO alpha/KC/CINC-1 Antibody

catalog :

MAB275

quantity :

100 ug (also 25 ug, 500 ug)

price :

369 USD

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

20326

reactivity :

human

application :

western blot, ELISA, neutralization

citations: 12

Reference
Ashander L, Lie S, Ma Y, Rochet E, Washington J, Furtado J, et al. Neutrophil Activities in Human Ocular Toxoplasmosis: An In Vitro Study With Human Cells. Invest Ophthalmol Vis Sci. 2019;60:4652-4660 pubmed publisher
Logue S, McGrath E, Cleary P, Greene S, Mnich K, Almanza A, et al. Inhibition of IRE1 RNase activity modulates the tumor cell secretome and enhances response to chemotherapy. Nat Commun. 2018;9:3267 pubmed publisher
Kitawaki Y, Nakamura Y, Kubota Nakayama F, Yamazaki Y, Miki Y, Hata S, et al. Tumor microenvironment in functional adrenocortical adenomas: immune cell infiltration in cortisol-producing adrenocortical adenoma. Hum Pathol. 2018;77:88-97 pubmed publisher
Kim E, Moon S, Kim D, Zhang X, Kim J. CXCL1 induces senescence of cancer-associated fibroblasts via autocrine loops in oral squamous cell carcinoma. PLoS ONE. 2018;13:e0188847 pubmed publisher
Henry C, Martin S. Caspase-8 Acts in a Non-enzymatic Role as a Scaffold for Assembly of a Pro-inflammatory "FADDosome" Complex upon TRAIL Stimulation. Mol Cell. 2017;65:715-729.e5 pubmed publisher
Chan T, Hsu C, Pai V, Liao W, Huang S, Tan K, et al. Metronomic chemotherapy prevents therapy-induced stromal activation and induction of tumor-initiating cells. J Exp Med. 2016;213:2967-2988 pubmed
Gelderblom M, Weymar A, Bernreuther C, Velden J, Arunachalam P, Steinbach K, et al. Neutralization of the IL-17 axis diminishes neutrophil invasion and protects from ischemic stroke. Blood. 2012;120:3793-802 pubmed publisher
Oladipo O, Conlon S, O Grady A, Purcell C, Wilson C, Maxwell P, et al. The expression and prognostic impact of CXC-chemokines in stage II and III colorectal cancer epithelial and stromal tissue. Br J Cancer. 2011;104:480-7 pubmed publisher
Meen A, Øynebråten I, Reine T, Duelli A, Svennevig K, Pejler G, et al. Serglycin is a major proteoglycan in polarized human endothelial cells and is implicated in the secretion of the chemokine GROalpha/CXCL1. J Biol Chem. 2011;286:2636-47 pubmed publisher
Moscova M, Marsh D, Baxter R. Protein chip discovery of secreted proteins regulated by the phosphatidylinositol 3-kinase pathway in ovarian cancer cell lines. Cancer Res. 2006;66:1376-83 pubmed
Numasaki M, Watanabe M, Suzuki T, Takahashi H, Nakamura A, McAllister F, et al. IL-17 enhances the net angiogenic activity and in vivo growth of human non-small cell lung cancer in SCID mice through promoting CXCR-2-dependent angiogenesis. J Immunol. 2005;175:6177-89 pubmed
Hagiwara H, Mitsumata M, Yamane T, Jin X, Yoshida Y. Laminar shear stress-induced GRO mRNA and protein expression in endothelial cells. Circulation. 1998;98:2584-90 pubmed

product information

brand :

R&D Systems

master code :

MAB275

SKU :

MAB275-100

product name :

Human/Primate CXCL1/GRO alpha/KC/CINC-1 Antibody

description :

The Human/Primate CXCL1/GRO alpha/KC/CINC-1 Antibody from R&D Systems is a mouse monoclonal antibody to CXCL1/GRO alpha/KC/CINC-1. This antibody reacts with human, primate. The Human/Primate CXCL1/GRO alpha/KC/CINC-1 Antibody has been validated for the following applications: Western Blot, Neutralization, Intracellular Staining by Flow Cytometry, CyTOF-ready, ELISA Capture (Matched Antibody Pair).

target :

CXCL1/GRO alpha/KC/CINC-1

category :

Primary Antibodies

unit size :

100 ug (also 25 ug, 500 ug)

buffer :

Lyophilized from a 0.2 µm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied as a 0.2 µm filtered solution in PBS.

clonality :

Monoclonal

clone :

20326

conjugate :

Unconjugated

host :

Mouse

immunogen :

E. coli -derived recombinant human CXCL1/GRO alpha/KC/CINC-1

isotype :

IgG2b

purity :

Protein A or G purified from hybridoma culture supernatant

species :

Human, Primate

specificity :

Detects human CXCL1/GRO alpha/KC/CINC-1 in ELISAs and Western blots. In Western blots, this antibody shows approximately 20% cross-reactivity with recombinant human (rh) CXCL2/GRO beta and rhCXCL3/GRO gamma and no cross-reactivity with recombinant rat (rr)CINC-1, rrCINC-2 alpha , rrCINC-2 beta , rrCINC-3, rhMIP-1 alpha , recombinant mouse (rm)MIP-1 alpha , rmMIP-1 beta , rmMIP-1 beta , rhMIP-1 delta , rmMIP-1 gamma , rmMIP-2, rhMIP-3 alpha , rmMIP-3 alpha , rrMIP-3 alpha , rhMIP-3 beta , or rmMIP-3 beta .

gene symbol :

CXCL1

endotoxin note :

<0.10 EU per 1 µg of the antibody by the LAL method.

catalog number base :

MAB275

applications :

Western Blot, Neutralization, Intracellular Staining by Flow Cytometry, CyTOF-ready, ELISA Capture (Matched Antibody Pair)

2020 USD :

339

2021 USD :

369 USD

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 6 months, -20 to -70 °C under sterile conditions after reconstitution.