Human IL-10 R alpha Antibody | R&D Systems MAB274 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

R&D Systems

product type :

antibody

product name :

Human IL-10 R alpha Antibody

catalog :

MAB274

quantity :

100 ug (also 25 ug, 500 ug)

price :

369 USD

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

37607

reactivity :

human

application :

neutralization, blocking or activating experiments

citations: 12

Published Application/Species/Sample/Dilution	Reference
blocking or activating experiments; human; 5 ug/ml; loading ...; fig 3d	Eyre R, Alferez D, Santiago Gómez A, Spence K, McConnell J, Hart C, et al. Microenvironmental IL1β promotes breast cancer metastatic colonisation in the bone via activation of Wnt signalling. Nat Commun. 2019;10:5016 pubmed publisher
	Thepmalee C, Panya A, Junking M, Chieochansin T, Yenchitsomanus P. Inhibition of IL-10 and TGF-β receptors on dendritic cells enhances activation of effector T-cells to kill cholangiocarcinoma cells. Hum Vaccin Immunother. 2018;14:1423-1431 pubmed publisher
	Brockmann L, Gagliani N, Steglich B, Giannou A, Kempski J, Pelczar P, et al. IL-10 Receptor Signaling Is Essential for TR1 Cell Function In Vivo. J Immunol. 2017;198:1130-1141 pubmed publisher
	Huynh L, Kusnadi A, Park S, Murata K, Park Min K, Ivashkiv L. Opposing regulation of the late phase TNF response by mTORC1-IL-10 signaling and hypoxia in human macrophages. Sci Rep. 2016;6:31959 pubmed publisher
	von Haehling S, von Lanzenauer S, Wolk K, HÃ¶flich C, Kunz S, GrÃ¼nberg B, et al. Interleukin-10 receptor-1 expression in monocyte-derived antigen-presenting cell populations: dendritic cells partially escape from IL-10's inhibitory mechanisms. Genes Immun. 2015;16:8-14 pubmed publisher
	Heine G, Drozdenko G, Grün J, Chang H, Radbruch A, Worm M. Autocrine IL-10 promotes human B-cell differentiation into IgM- or IgG-secreting plasmablasts. Eur J Immunol. 2014;44:1615-21 pubmed publisher
	Evans H, Roostalu U, Walter G, Gullick N, Frederiksen K, Roberts C, et al. TNF-? blockade induces IL-10 expression in human CD4+ T cells. Nat Commun. 2014;5:3199 pubmed publisher
	Jagannathan P, Eccles James I, Bowen K, Nankya F, Auma A, Wamala S, et al. IFN?/IL-10 co-producing cells dominate the CD4 response to malaria in highly exposed children. PLoS Pathog. 2014;10:e1003864 pubmed publisher
	Jenkins C, Garcia W, Godwin M, Spencer J, Stern J, Abendroth A, et al. Immunomodulatory properties of a viral homolog of human interleukin-10 expressed by human cytomegalovirus during the latent phase of infection. J Virol. 2008;82:3736-50 pubmed publisher
	Godfrey W, Spoden D, Ge Y, Baker S, Liu B, Levine B, et al. Cord blood CD4(+)CD25(+)-derived T regulatory cell lines express FoxP3 protein and manifest potent suppressor function. Blood. 2005;105:750-8 pubmed
	Chang W, Baumgarth N, Yu D, Barry P. Human cytomegalovirus-encoded interleukin-10 homolog inhibits maturation of dendritic cells and alters their functionality. J Virol. 2004;78:8720-31 pubmed
	Godfrey W, Ge Y, Spoden D, Levine B, June C, Blazar B, et al. In vitro-expanded human CD4(+)CD25(+) T-regulatory cells can markedly inhibit allogeneic dendritic cell-stimulated MLR cultures. Blood. 2004;104:453-61 pubmed

product information

brand :

R&D Systems

master code :

MAB274

SKU :

MAB274-100

product name :

Human IL-10 R alpha Antibody

description :

The Human IL-10 R alpha Antibody from R&D Systems is a mouse monoclonal antibody to IL-10R alpha. This antibody reacts with human. The Human IL-10 R alpha Antibody has been validated for the following applications: Neutralization.

target :

IL-10R alpha

category :

Primary Antibodies

unit size :

100 ug (also 25 ug, 500 ug)

buffer :

Lyophilized from a 0.2 µm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied as a 0.2 µm filtered solution in PBS.

clonality :

Monoclonal

clone :

37607

conjugate :

Unconjugated

host :

Mouse

immunogen :

S. frugiperda insect ovarian cell line Sf 21-derived recombinant human IL-10 R alpha , His22-Asn235, Accession # Q13651.1

isotype :

IgG1

purity :

Protein A or G purified from hybridoma culture supernatant

species :

Human

specificity :

Detects human IL-10 R alpha in direct ELISAs. In this format, this antibody does not cross-react with recombinant mouse IL-10 R alpha .

gene symbol :

IL10RA

endotoxin note :

<0.10 EU per 1 µg of the antibody by the LAL method.

catalog number base :

MAB274

accessionNumbers :

Q13651.1

applications :

Neutralization

2020 USD :

339

2021 USD :

369 USD

alt names :

CD210 antigen, CDw210a, HIL-10R, IBD28, IL-10 receptor subunit alpha, IL10R alpha, IL-10R subunit 1, IL-10R1, IL10RA, IL-10RA, IL10RIL-10R subunit alpha, interleukin 10 receptor, alpha, interleukin-10 receptor alpha chain, Interleukin-10 receptor subunit 1, interleukin-10 receptor subunit alpha

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 6 months, -20 to -70 °C under sterile conditions after reconstitution.