product summary
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company name :
R&D Systems
product type :
antibody
product name :
Human IL-10 R alpha Antibody
catalog :
MAB274-100
quantity :
100 ug (also 25 ug, 500 ug)
price :
479 USD
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
37607
reactivity :
human
application :
neutralization, flow cytometry
more info or order :
R&D Systems product webpage
citations: 19
Reference
Shankar S, Stolp J, Juvet S, Beckett J, Macklin P, Issa F, et al. Ex vivo-expanded human CD19+TIM-1+ regulatory B cells suppress immune responses in vivo and are dependent upon the TIM-1/STAT3 axis. Nat Commun. 2022;13:3121 pubmed publisher
Koto S, Chihara N, Akatani R, Nakano H, Hara A, Sekiguchi K, et al. Transcription Factor c-Maf Promotes Immunoregulation of Programmed Cell Death 1-Expressed CD8+ T Cells in Multiple Sclerosis. Neurol Neuroimmunol Neuroinflamm. 2022;9: pubmed publisher
Ho T, Pfeffer K, Weiss G, Ruiz Y, Lake D. Identification of a CD4+ T cell line with Treg-like activity. Hum Immunol. 2022;83:281-294 pubmed publisher
Zhang C, Delawary M, Huang P, Korchak J, Suda K, Zubair A. IL-10 mRNA Engineered MSCs Demonstrate Enhanced Anti-Inflammation in an Acute GvHD Model. Cells. 2021;10: pubmed publisher
Chang C, Liu C, Pan S, Huang W, Peng C, Hsu H. Targeting of interleukin-10 receptor by a potential human interleukin-10 peptide efficiently blocks interleukin-10 pathway-dependent cell proliferation. Tzu Chi Med J. 2020;32:245-253 pubmed publisher
Eyre R, Alferez D, Santiago Gómez A, Spence K, McConnell J, Hart C, et al. Microenvironmental IL1β promotes breast cancer metastatic colonisation in the bone via activation of Wnt signalling. Nat Commun. 2019;10:5016 pubmed publisher
Porichis F, Hart M, Massa A, Everett H, Morou A, Richard J, et al. Immune Checkpoint Blockade Restores HIV-Specific CD4 T Cell Help for NK Cells. J Immunol. 2018;201:971-981 pubmed publisher
Thepmalee C, Panya A, Junking M, Chieochansin T, Yenchitsomanus P. Inhibition of IL-10 and TGF-β receptors on dendritic cells enhances activation of effector T-cells to kill cholangiocarcinoma cells. Hum Vaccin Immunother. 2018;14:1423-1431 pubmed publisher
Brockmann L, Gagliani N, Steglich B, Giannou A, Kempski J, Pelczar P, et al. IL-10 Receptor Signaling Is Essential for TR1 Cell Function In Vivo. J Immunol. 2017;198:1130-1141 pubmed publisher
Huynh L, Kusnadi A, Park S, Murata K, Park Min K, Ivashkiv L. Opposing regulation of the late phase TNF response by mTORC1-IL-10 signaling and hypoxia in human macrophages. Sci Rep. 2016;6:31959 pubmed publisher
von Haehling S, von Lanzenauer S, Wolk K, Höflich C, Kunz S, Grünberg B, et al. Interleukin-10 receptor-1 expression in monocyte-derived antigen-presenting cell populations: dendritic cells partially escape from IL-10's inhibitory mechanisms. Genes Immun. 2015;16:8-14 pubmed publisher
Heine G, Drozdenko G, Grün J, Chang H, Radbruch A, Worm M. Autocrine IL-10 promotes human B-cell differentiation into IgM- or IgG-secreting plasmablasts. Eur J Immunol. 2014;44:1615-21 pubmed publisher
Evans H, Roostalu U, Walter G, Gullick N, Frederiksen K, Roberts C, et al. TNF-? blockade induces IL-10 expression in human CD4+ T cells. Nat Commun. 2014;5:3199 pubmed publisher
Jagannathan P, Eccles James I, Bowen K, Nankya F, Auma A, Wamala S, et al. IFN?/IL-10 co-producing cells dominate the CD4 response to malaria in highly exposed children. PLoS Pathog. 2014;10:e1003864 pubmed publisher
Gruber S, Gloria Luciani M, Grundtner P, Zdanov A, Gasche C. Differential signaling of cmvIL-10 through common variants of the IL-10 receptor 1. Eur J Immunol. 2008;38:3365-75 pubmed publisher
Jenkins C, Garcia W, Godwin M, Spencer J, Stern J, Abendroth A, et al. Immunomodulatory properties of a viral homolog of human interleukin-10 expressed by human cytomegalovirus during the latent phase of infection. J Virol. 2008;82:3736-50 pubmed publisher
Godfrey W, Spoden D, Ge Y, Baker S, Liu B, Levine B, et al. Cord blood CD4(+)CD25(+)-derived T regulatory cell lines express FoxP3 protein and manifest potent suppressor function. Blood. 2005;105:750-8 pubmed
Chang W, Baumgarth N, Yu D, Barry P. Human cytomegalovirus-encoded interleukin-10 homolog inhibits maturation of dendritic cells and alters their functionality. J Virol. 2004;78:8720-31 pubmed
Godfrey W, Ge Y, Spoden D, Levine B, June C, Blazar B, et al. In vitro-expanded human CD4(+)CD25(+) T-regulatory cells can markedly inhibit allogeneic dendritic cell-stimulated MLR cultures. Blood. 2004;104:453-61 pubmed
product information
master code :
MAB274
SKU :
MAB274-100
product name :
Human IL-10 R alpha Antibody
unit size :
100 ug (also 25 ug, 500 ug)
description :
The Human IL-10 R alpha Antibody from R&D Systems is a mouse monoclonal antibody to IL-10R alpha. This antibody reacts with human. The Human IL-10 R alpha Antibody has been validated for the following applications: Blocking,Flow Cytometry,Neutralization,Functional Assay.
target :
IL-10 R alpha
category :
Primary Antibodies
buffer :
Lyophilized from a 0.2 ╡m filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 ╡m filtered solution in PBS.
clonality :
Monoclonal
clone :
37607
conjugate :
Unconjugated
host :
Mouse
immunogen :
S. frugiperda insect ovarian cell line Sf 21-derived recombinant human IL-10 R alpha , His22-Asn235, Accession # Q13651.1
isotype :
IgG1
purity :
Protein A or G purified from hybridoma culture supernatant
species :
Human
specificity :
Detects human IL-10 R alpha in direct ELISAs. In this format, this antibody does not cross-react with recombinant mouse IL-10 R alpha .
gene symbol :
IL10RA
endotoxin note :
<0.10 EU per 1 ╡g of the antibody by the LAL method.
top caption :
IL-10 Inhibition of IL-1ss secretion and Neutralization by Human IL-10 Ra Antibody.
accessionNumbers :
Q13651.1
applications :
Blocking,Flow Cytometry,Neutralization,Functional Assay
USD :
479 USD
alt names :
CD210 antigen, CDw210a, HIL-10R, IBD28, IL-10 receptor subunit alpha, IL10R alpha, IL-10R subunit 1, IL-10R1, IL10RA, IL-10RA, IL10RIL-10R subunit alpha, interleukin 10 receptor, alpha, interleukin-10 receptor alpha chain, Interleukin-10 receptor subunit 1, interleukin-10 receptor subunit alpha
storage :
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 6 months, -20 to -70 ░C under sterile conditions after reconstitution.
more info or order :
R&D Systems product webpage
company information
R&D Systems
614 McKinley Place N.E.
Minneapolis, MN 55413
info@RnDSystems.com
https://www.rndsystems.com
800 343-7475
headquarters: USA
R&D Systems develops and manufactures high-quality proteins and serves as a world leader in immunoassays. R&D Systems also produces quality antibodies, antibody arrays, stem cell and cell culture products, and cell selection and detection products, serving the life science and diagnostics industry.