Human CCL4/MIP-1 beta MAb (Clone 24006) | R&D Systems MAB271-100 product information

product summary

company name :

R&D Systems

product type :

antibody

product name :

Human CCL4/MIP-1 beta MAb (Clone 24006)

catalog :

MAB271-100

quantity :

100 ug (also 25 ug, 500 ug)

price :

489 USD

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

24006

reactivity :

human

application :

western blot, ELISA, immunohistochemistry, immunocytochemistry, neutralization, flow cytometry, immunohistochemistry - frozen section

more info or order :

R&D Systems product webpage

citations: 26

Reference
Wang J, Chai Q, Lei Z, Wang Y, He J, Ge P, et al. LILRB1-HLA-G axis defines a checkpoint driving natural killer cell exhaustion in tuberculosis. EMBO Mol Med. 2024;16:1755-1790 pubmed publisher
Cheng Y, Acedera J, Li Y, Shieh S. A keratinocyte-adipocyte signaling loop is reprogrammed by loss of BTG3 to augment skin carcinogenesis. Cell Death Differ. 2024;31:970-982 pubmed publisher
Vitanza N, Wilson A, Huang W, Seidel K, Brown C, Gustafson J, et al. Intraventricular B7-H3 CAR T Cells for Diffuse Intrinsic Pontine Glioma: Preliminary First-in-Human Bioactivity and Safety. Cancer Discov. 2023;13:114-131 pubmed publisher
Young A, Kumasaka N, Calvert F, Hammond T, Knights A, Panousis N, et al. A map of transcriptional heterogeneity and regulatory variation in human microglia. Nat Genet. 2021;53:861-868 pubmed publisher
Gruber C, Patel R, Trachtman R, Lepow L, Amanat F, Krammer F, et al. Mapping Systemic Inflammation and Antibody Responses in Multisystem Inflammatory Syndrome in Children (MIS-C). Cell. 2020;183:982-995.e14 pubmed publisher
Toledo N, Li H, Omange R, Dacoba T, Crecente Campo J, Schalk D, et al. Cervico-Vaginal Inflammatory Cytokine and Chemokine Responses to Two Different SIV Immunogens. Front Immunol. 2020;11:1935 pubmed publisher
Juno J, Wragg K, Kristensen A, Lee W, Selva K, van der Sluis R, et al. Modulation of the CCR5 Receptor/Ligand Axis by Seminal Plasma and the Utility of In Vitro versus In Vivo Models. J Virol. 2019;93: pubmed publisher
van Hooij A, Tjon Kon Fat E, Batista da Silva M, Carvalho Bouth R, Cunha Messias A, Gobbo A, et al. Evaluation of Immunodiagnostic Tests for Leprosy in Brazil, China and Ethiopia. Sci Rep. 2018;8:17920 pubmed publisher
Li L, Liu Y, Zhan Y, Zhu Y, Li Y, Xie D, et al. High levels of CCL2 or CCL4 in the tumor microenvironment predict unfavorable survival in lung adenocarcinoma. Thorac Cancer. 2018;9:775-784 pubmed publisher
Buggert M, Nguyen S, McLane L, Steblyanko M, Anikeeva N, Paquin Proulx D, et al. Limited immune surveillance in lymphoid tissue by cytolytic CD4+ T cells during health and HIV disease. PLoS Pathog. 2018;14:e1006973 pubmed publisher
Auclair S, Liu F, Niu Q, Hou W, Churchyard G, Morgan C, et al. Distinct susceptibility of HIV vaccine vector-induced CD4 T cells to HIV infection. PLoS Pathog. 2018;14:e1006888 pubmed publisher
Kageyama S, Ikeda H, Miyahara Y, Imai N, Ishihara M, Saito K, et al. Adoptive Transfer of MAGE-A4 T-cell Receptor Gene-Transduced Lymphocytes in Patients with Recurrent Esophageal Cancer. Clin Cancer Res. 2015;21:2268-77 pubmed publisher
Cardone M, Ikeda K, Varano B, Gessani S, Conti L. HIV-1-induced impairment of dendritic cell cross talk with Î³Î´ T lymphocytes. J Virol. 2015;89:4798-808 pubmed publisher
Scalley Kim M, Hess B, Kelly R, Krostag A, Lustig K, Marken J, et al. A novel highly potent therapeutic antibody neutralizes multiple human chemokines and mimics viral immune modulation. PLoS ONE. 2012;7:e43332 pubmed publisher
Franciszkiewicz K, Le Floc h A, Jalil A, Vigant F, Robert T, Vergnon I, et al. Intratumoral induction of CD103 triggers tumor-specific CTL function and CCR5-dependent T-cell retention. Cancer Res. 2009;69:6249-55 pubmed publisher
Hu H, Kwun J, Aizenstein B, Knechtle S. Noninvasive detection of acute and chronic injuries in human renal transplant by elevation of multiple cytokines/chemokines in urine. Transplantation. 2009;87:1814-20 pubmed publisher
Pfleger C, Kaas A, Hansen L, Alizadeh B, Hougaard P, Holl R, et al. Relation of circulating concentrations of chemokine receptor CCR5 ligands to C-peptide, proinsulin and HbA1c and disease progression in type 1 diabetes. Clin Immunol. 2008;128:57-65 pubmed publisher
Biancotto A, Iglehart S, Lisco A, Vanpouille C, Grivel J, Lurain N, et al. Upregulation of human cytomegalovirus by HIV type 1 in human lymphoid tissue ex vivo. AIDS Res Hum Retroviruses. 2008;24:453-62 pubmed publisher
Huang S, Chen C, Schatz F, Rahman M, Abrahams V, Lockwood C. Pre-eclampsia is associated with dendritic cell recruitment into the uterine decidua. J Pathol. 2008;214:328-36 pubmed
Weindl G, Naglik J, Kaesler S, Biedermann T, Hube B, Korting H, et al. Human epithelial cells establish direct antifungal defense through TLR4-mediated signaling. J Clin Invest. 2007;117:3664-72 pubmed
Grivel J, Elliott J, Lisco A, Biancotto A, Condack C, Shattock R, et al. HIV-1 pathogenesis differs in rectosigmoid and tonsillar tissues infected ex vivo with CCR5- and CXCR4-tropic HIV-1. AIDS. 2007;21:1263-72 pubmed
Biancotto A, Grivel J, Iglehart S, Vanpouille C, Lisco A, Sieg S, et al. Abnormal activation and cytokine spectra in lymph nodes of people chronically infected with HIV-1. Blood. 2007;109:4272-9 pubmed
Filer A, Parsonage G, Smith E, Osborne C, Thomas A, Curnow S, et al. Differential survival of leukocyte subsets mediated by synovial, bone marrow, and skin fibroblasts: site-specific versus activation-dependent survival of T cells and neutrophils. Arthritis Rheum. 2006;54:2096-108 pubmed
Gounni Abdelilah S, Wellemans V, Agouli M, Guenounou M, Hamid Q, Beck L, et al. Increased expression of Th2-associated chemokines in bullous pemphigoid disease. Role of eosinophils in the production and release of these chemokines. Clin Immunol. 2006;120:220-31 pubmed
Dioszeghy V, Benlhassan Chahour K, Delache B, Dereuddre Bosquet N, Aubenque C, Gras G, et al. Changes in soluble factor-mediated CD8+ cell-derived antiviral activity in cynomolgus macaques infected with simian immunodeficiency virus SIVmac251: relationship to biological markers of progression. J Virol. 2006;80:236-45 pubmed
Megjugorac N, Young H, Amrute S, Olshalsky S, Fitzgerald Bocarsly P. Virally stimulated plasmacytoid dendritic cells produce chemokines and induce migration of T and NK cells. J Leukoc Biol. 2004;75:504-14 pubmed

product information

brand :

R&D Systems

master code :

MAB271

SKU :

MAB271-100

product name :

Human CCL4/MIP-1 beta MAb (Clone 24006)

unit size :

100 ug (also 25 ug, 500 ug)

seo description :

The Human CCL4/MIP-1 beta MAb (Clone 24006) from R&D Systems is a mouse monoclonal antibody to CCL4/MIP-1 beta. This antibody reacts with human,primate - macaca fascicularis (crab-eating monkey or cynomolgus macaque). The Human CCL4/MIP-1 beta MAb (Clone 24006) has been validated for the following applications: CyTOF-reported,Neutralization,Antibody Array Development,ELISA Development,ELISpot Development,Immunodepletion,Lateral Flow,Luminex Development,Flow Cytometry,Immunohistochemistry,Immunohistochemistry-Frozen,Immunocytochemistry,Western Blot,ELISA Capture (Matched Antibody Pair),Intracellular Staining by Flow Cytometry,CyTOF-ready.

target :

CCL4/MIP-1 beta

category :

Primary Antibodies

buffer :

Lyophilized from a 0.2 ╡m filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 ╡m filtered solution in PBS.

clonality :

Monoclonal

clone :

24006

conjugate :

Unconjugated

dilution :

Western Blot 1 ug/mL, Neutralization 0.3-1.2 ug/mL, Intracellular Staining by Flow Cytometry 0.25 ug/10^6 cells, CyTOF-ready, ELISA Capture (Matched Antibody Pair) 2-8 ug/mL

host :

Mouse

immunogen :

S. frugiperda insect ovarian cell line Sf 21-derived recombinant human CCL4/MIP-1▀, Ala24-Asn92, Accession # P13236

isotype :

IgG2b

purity :

Protein A or G purified from hybridoma culture supernatant

species :

Human,Primate - Macaca fascicularis (Crab-eating Monkey or Cynomolgus Macaque)

specificity :

Detects human CCL4/MIP-1▀ in ELISAs and Western blots. In Western blots, less than 4% cross-reactivity with recombinant human (rh) CCL3/MIP-1 alpha and no cross-reactivity with recombinant mouse (rm) CCL3/MIP-1 alpha , rmCCL4/MIP-1▀, rhCXCL8/IL-8, rhCCL5, rhCXCL1, rhCXCL2, or rhCXCL3 is observed.

gene symbol :

CCL4

endotoxin note :

<0.10 EU per 1 ╡g of the antibody by the LAL method.

top caption :

Chemotaxis Induced by CCL4/MIP-1ss and Neutralization by Human CCL4/MIP-1ss Antibody.

accessionNumbers :

P13236

applications :

Western Blot,ELISA Capture (Matched Antibody Pair),Intracellular Staining by Flow Cytometry,CyTOF-ready,Antibody Array Development,ELISA Development,ELISpot Development,Immunodepletion,Lateral Flow,Luminex Development,Flow Cytometry,Immunohistochemistry,Immunohistochemistry-Frozen,Neutralization,Immunocytochemistry,CyTOF-reported

USD :

489 USD

alt names :

ACT2, ACT-2, AT744.1, C-C motif chemokine 4, chemokine (C-C motif) ligand 4, Exodus-3, G-26, G-26 T-lymphocyte-secreted protein, HC21, LAG1, LAG-1, Lymphocyte activation gene 1 protein, Macrophage inflammatory protein 1-beta, MIP1 beta, MIP-1 beta, MIP1B, MIP1B1, MIP-1-beta, MIP-1-beta(1-69), PAT 744, Protein H400, SCYA2, SCYA4, secreted protein G-26, SIS-gamma, small inducible cytokine A4 (homologous to mouse Mip-1b), Small-inducible cytokine A4, T-cell activation protein 2

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 6 months, -20 to -70 ░C under sterile conditions after reconstitution.

more info or order :

R&D Systems product webpage