Human CCL3/CCL4 Antibody | R&D Systems MAB270-100 product information

product summary

company name :

R&D Systems

product type :

antibody

product name :

Human CCL3/CCL4 Antibody

catalog :

MAB270-100

quantity :

100 ug (also 25 ug, 500 ug)

price :

469 USD

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

93321

reactivity :

human

application :

western blot, immunohistochemistry, immunocytochemistry, neutralization, immunohistochemistry - frozen section

more info or order :

R&D Systems product webpage

citations: 14

Reference
Cichocki F, Bjordahl R, Gaidarova S, Mahmood S, Abujarour R, Wang H, et al. iPSC-derived NK cells maintain high cytotoxicity and enhance in vivo tumor control in concert with T cells and anti-PD-1 therapy. Sci Transl Med. 2020;12: pubmed publisher
Juno J, Wragg K, Kristensen A, Lee W, Selva K, van der Sluis R, et al. Modulation of the CCR5 Receptor/Ligand Axis by Seminal Plasma and the Utility of In Vitro versus In Vivo Models. J Virol. 2019;93: pubmed publisher
Sun W, Meednu N, Rosenberg A, Rangel Moreno J, Wang V, Glanzman J, et al. B cells inhibit bone formation in rheumatoid arthritis by suppressing osteoblast differentiation. Nat Commun. 2018;9:5127 pubmed publisher
Jordan L, Erlandsson M, Fenner B, Davies R, Harvey A, Choy E, et al. Inhibition of CCL3 abrogated precursor cell fusion and bone erosions in human osteoclast cultures and murine collagen-induced arthritis. Rheumatology (Oxford). 2018;57:2042-2052 pubmed publisher
Auclair S, Liu F, Niu Q, Hou W, Churchyard G, Morgan C, et al. Distinct susceptibility of HIV vaccine vector-induced CD4 T cells to HIV infection. PLoS Pathog. 2018;14:e1006888 pubmed publisher
Rump L, Mattey D, Kehoe O, Middleton J. An initial investigation into endothelial CC chemokine expression in the human rheumatoid synovium. Cytokine. 2017;97:133-140 pubmed publisher
Baldwin H, Singh M, Codullo V, King V, Wilson H, McInnes I, et al. Elevated ACKR2 expression is a common feature of inflammatory arthropathies. Rheumatology (Oxford). 2017;56:1607-1617 pubmed publisher
Li Y, Zheng Y, Li T, Wang Q, Qian J, Lu Y, et al. Chemokines CCL2, 3, 14 stimulate macrophage bone marrow homing, proliferation, and polarization in multiple myeloma. Oncotarget. 2015;6:24218-29 pubmed
Kanegasaki S, Matsushima K, Shiraishi K, Nakagawa K, Tsuchiya T. Macrophage inflammatory protein derivative ECI301 enhances the alarmin-associated abscopal benefits of tumor radiotherapy. Cancer Res. 2014;74:5070-8 pubmed publisher
Yin X, Johns S, Kim D, Mikulski Z, SALANGA C, Handel T, et al. Lymphatic specific disruption in the fine structure of heparan sulfate inhibits dendritic cell traffic and functional T cell responses in the lymph node. J Immunol. 2014;192:2133-42 pubmed publisher
Scalley Kim M, Hess B, Kelly R, Krostag A, Lustig K, Marken J, et al. A novel highly potent therapeutic antibody neutralizes multiple human chemokines and mimics viral immune modulation. PLoS ONE. 2012;7:e43332 pubmed publisher
Snyder Cappione J, Tincati C, Eccles James I, Cappione A, Ndhlovu L, Koth L, et al. A comprehensive ex vivo functional analysis of human NKT cells reveals production of MIP1-? and MIP1-?, a lack of IL-17, and a Th1-bias in males. PLoS ONE. 2010;5:e15412 pubmed publisher
Franciszkiewicz K, Le Floc h A, Jalil A, Vigant F, Robert T, Vergnon I, et al. Intratumoral induction of CD103 triggers tumor-specific CTL function and CCR5-dependent T-cell retention. Cancer Res. 2009;69:6249-55 pubmed publisher
Fischer J, West J, Agochukwu N, Suire C, Hale Donze H. Induction of host chemotactic response by Encephalitozoon spp. Infect Immun. 2007;75:1619-25 pubmed

product information

master code :

MAB270

SKU :

MAB270-100

product name :

Human CCL3/CCL4 Antibody

unit size :

100 ug (also 25 ug, 500 ug)

description :

The Human CCL3/CCL4 Antibody from R&D Systems is a mouse monoclonal antibody to CCL3/CCL4. This antibody reacts with human,mouse. The Human CCL3/CCL4 Antibody has been validated for the following applications: Neutralization,Blocking,Co-Immunoprecipitation,ELISpot Development,Immunohistochemistry,Immunohistochemistry-Frozen,Immunocytochemistry,Western Blot.

target :

CCL3/CCL4

category :

Primary Antibodies

buffer :

Lyophilized from a 0.2 ╡m filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 ╡m filtered solution in PBS.

clonality :

Monoclonal

clone :

93321

conjugate :

Unconjugated

host :

Mouse

immunogen :

E. coli -derived recombinant human CCL3/MIP-1 alpha , Ala27-Ala92, Accession # P10147

isotype :

IgG1

purity :

Protein A or G purified from hybridoma culture supernatant

species :

Human,Mouse

specificity :

Detects human CCL3/MIP-1 alpha in direct ELISAs and Western blots. In direct ELISAs, greater than 75% cross-reactivity with recombinant human (rh) CCL4/MIP-1▀ is observed while approximately 30% cross-reactivity with recombinant mouse (rm) CCL3, rmCCL4/MIP-1▀, and rhCCL14 is observed. No cross-reactivity with rhCCL1, 2, 5, 7, 8, 11, 13, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, rmCCL1, 2, 5, 6, 7, 9/10/MIP-1 gamma , 11, 12, 17, 19, 20, 21, 22, 24, 25, or recombinant rat CCL20 is observed.

gene symbol :

CCL3

endotoxin note :

<0.10 EU per 1 ╡g of the antibody by the LAL method.

accessionNumbers :

P10147

applications :

Neutralization,Blocking,Co-Immunoprecipitation,ELISpot Development,Immunohistochemistry,Immunohistochemistry-Frozen,Immunocytochemistry,Western Blot

USD :

469 USD

alt names :

C-C motif chemokine;C-C motif chemokine 3;G0S19-1;LD78ALPHA;MIP1A;MIP-1-alpha;SCYA3, Exodus-3, G0S19-1, LD78a, MIP1 alpha, MIP-1 alpha, MIP1 beta, MIP-1 beta, MIP1A, PAT 464.1, SCYA3, SIS-beta

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 6 months, -20 to -70 ░C under sterile conditions after reconstitution.

more info or order :

R&D Systems product webpage