product summary
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company name :
R&D Systems
product type :
antibody
product name :
Human CXCL10/IP-10/CRG-2 Antibody
catalog :
MAB266-100
quantity :
100 ug (also 25 ug, 500 ug)
price :
479 USD
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
33036
reactivity :
human, mouse, chimpanzee, rhesus macaque
application :
ELISA, immunohistochemistry, immunocytochemistry, neutralization, flow cytometry, immunohistochemistry - paraffin section
more info or order :
citations: 42
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Cecchinato V, Bernasconi E, Speck R, Proietti M, Sauermann U, D Agostino G, et al. Impairment of CCR6+ and CXCR3+ Th Cell Migration in HIV-1 Infection Is Rescued by Modulating Actin Polymerization. J Immunol. 2017;198:184-195 pubmed
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Xu W, Joo H, Clayton S, Dullaers M, Herve M, Blankenship D, et al. Macrophages induce differentiation of plasma cells through CXCL10/IP-10. J Exp Med. 2012;209:1813-23, S1-2 pubmed
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Qui H, Ferrell E, Nolan N, Phelps B, Tabibiazar R, Whitney D, et al. Fluorescence single-molecule counting assays for high-sensitivity detection of cytokines and chemokines. Clin Chem. 2007;53:2010-2 pubmed
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Pfleger C, Schloot N, ter Veld F. Effect of serum content and diluent selection on assay sensitivity and signal intensity in multiplex bead-based immunoassays. J Immunol Methods. 2008;329:214-8 pubmed
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Cheadle E, Riyad K, Subar D, Rothwell D, Ashton G, Batha H, et al. Eotaxin-2 and colorectal cancer: a potential target for immune therapy. Clin Cancer Res. 2007;13:5719-28 pubmed
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Liu L, Bates M, Jarjour N, Busse W, Bertics P, Kelly E. Generation of Th1 and Th2 chemokines by human eosinophils: evidence for a critical role of TNF-alpha. J Immunol. 2007;179:4840-8 pubmed
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Winter D, Moser J, Kriehuber E, Wiesner C, Knobler R, Trautinger F, et al. Down-modulation of CXCR3 surface expression and function in CD8+ T cells from cutaneous T cell lymphoma patients. J Immunol. 2007;179:4272-82 pubmed
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Grivel J, Elliott J, Lisco A, Biancotto A, Condack C, Shattock R, et al. HIV-1 pathogenesis differs in rectosigmoid and tonsillar tissues infected ex vivo with CCR5- and CXCR4-tropic HIV-1. AIDS. 2007;21:1263-72 pubmed
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Biancotto A, Grivel J, Iglehart S, Vanpouille C, Lisco A, Sieg S, et al. Abnormal activation and cytokine spectra in lymph nodes of people chronically infected with HIV-1. Blood. 2007;109:4272-9 pubmed
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Gounni Abdelilah S, Wellemans V, Agouli M, Guenounou M, Hamid Q, Beck L, et al. Increased expression of Th2-associated chemokines in bullous pemphigoid disease. Role of eosinophils in the production and release of these chemokines. Clin Immunol. 2006;120:220-31 pubmed
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Edwards M, Johnson M, Johnston S. Combination therapy: Synergistic suppression of virus-induced chemokines in airway epithelial cells. Am J Respir Cell Mol Biol. 2006;34:616-24 pubmed
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Wenzel J, Wörenkämper E, Freutel S, Henze S, Haller O, Bieber T, et al. Enhanced type I interferon signalling promotes Th1-biased inflammation in cutaneous lupus erythematosus. J Pathol. 2005;205:435-42 pubmed
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Sui Y, Li S, Pinson D, Adany I, Li Z, Villinger F, et al. Simian human immunodeficiency virus-associated pneumonia correlates with increased expression of MCP-1, CXCL10, and viral RNA in the lungs of rhesus macaques. Am J Pathol. 2005;166:355-65 pubmed
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Kohrgruber N, Groger M, Meraner P, Kriehuber E, Petzelbauer P, Brandt S, et al. Plasmacytoid dendritic cell recruitment by immobilized CXCR3 ligands. J Immunol. 2004;173:6592-602 pubmed
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Øynebråten I, Bakke O, Brandtzaeg P, Johansen F, Haraldsen G. Rapid chemokine secretion from endothelial cells originates from 2 distinct compartments. Blood. 2004;104:314-20 pubmed
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Hurst S, McLoughlin R, Monslow J, Owens S, Morgan L, Fuller G, et al. Secretion of oncostatin M by infiltrating neutrophils: regulation of IL-6 and chemokine expression in human mesothelial cells. J Immunol. 2002;169:5244-51 pubmed
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product information
brand :
R&D Systems
master code :
MAB266
SKU :
MAB266-100
product name :
Human CXCL10/IP-10/CRG-2 Antibody
unit size :
100 ug (also 25 ug, 500 ug)
seo description :
The Human CXCL10/IP-10/CRG-2 Antibody from R&D Systems is a mouse monoclonal antibody to CXCL10/IP-10/CRG-2. This antibody reacts with human,mouse,primate - macaca mulatta (rhesus macaque),primate - pan troglodytes (chimpanzee). The Human CXCL10/IP-10/CRG-2 Antibody has been validated for the following applications: Neutralization,Bioassay,ELISA Development,ELISA Development (Capture),Immunoassay Development,Immunodepletion,Luminex Development,Flow Cytometry,Functional Assay,Cell Selection,ELISA Capture,Immunohistochemistry,Immunohistochemistry-Paraffin,Immunocytochemistry,ELISA Capture (Matched Antibody Pair),Intracellular Staining by Flow Cytometry,CyTOF-ready.
target :
CXCL10/IP-10/CRG-2
category :
Primary Antibodies
buffer :
Lyophilized from a 0.2 ╡m filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 ╡m filtered solution in PBS.
clonality :
Monoclonal
clone :
33036
conjugate :
Unconjugated
dilution :
Neutralization 0.5-2.0 ug/mL, Intracellular Staining by Flow Cytometry 2.5 ug/10^6 cells, CyTOF-ready, ELISA Capture (Matched Antibody Pair) 2-8 ug/mL
host :
Mouse
immunogen :
E. coli -derived recombinant human CXCL10/IP-10/CRG-2, Val22-Pro98, Accession # P02778.2
isotype :
IgG1
purity :
Protein A or G purified from ascites
species :
Human,Mouse,Primate - Macaca mulatta (Rhesus Macaque),Primate - Pan troglodytes (Chimpanzee)
specificity :
Detects human CXCL10/IP-10/CRG-2 in ELISAs.
gene symbol :
CXCL10
endotoxin note :
<0.10 EU per 1 ╡g of the antibody by the LAL method.
top caption :
Chemotaxis Induced by CXCL10/IP-10 and Neutralization by Human CXCL10/IP-10 Antibody.
accessionNumbers :
P02778.2
applications :
ELISA Capture (Matched Antibody Pair),Intracellular Staining by Flow Cytometry,CyTOF-ready,Bioassay,ELISA Development,ELISA Development (Capture),Immunoassay Development,Immunodepletion,Luminex Development,Flow Cytometry,Immunohistochemistry,Immunohistochemistry-Paraffin,Neutralization,Immunocytochemistry,Functional Assay,Cell Selection,ELISA Capture
USD :
479 USD
alt names :
C7, chemokine (C-X-C motif) ligand 10, crg-2, CRG2, gIP-10, IFI10, INP10, IP-10, mob-1, SCYB10
storage :
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 6 months, -20 to -70 ░C under sterile conditions after reconstitution.
more info or order :
company information

R&D Systems
614 McKinley Place N.E.
Minneapolis, MN 55413
Minneapolis, MN 55413
info@RnDSystems.com
https://www.rndsystems.com800 343-7475
headquarters: USA
R&D Systems develops and manufactures high-quality proteins and serves as a world leader in immunoassays. R&D Systems also produces quality antibodies, antibody arrays, stem cell and cell culture products, and cell selection and detection products, serving the life science and diagnostics industry.
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