Human Nectin-4 Antibody | R&D Systems MAB2659 product information

product summary

company name :

R&D Systems

product type :

antibody

product name :

Human Nectin-4 Antibody

catalog :

MAB2659

quantity :

100 ug (also 25 ug)

price :

489 USD

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

337516

reactivity :

human

application :

western blot, immunocytochemistry, flow cytometry

more info or order :

R&D Systems product webpage

citations: 7

Reference
Reches A, Ophir Y, Stein N, Kol I, Isaacson B, Charpak Amikam Y, et al. Nectin4 is a novel TIGIT ligand which combines checkpoint inhibition and tumor specificity. J Immunother Cancer. 2020;8: pubmed publisher
Generous A, Harrison O, Troyanovsky R, Mateo M, Navaratnarajah C, Donohue R, et al. Trans-endocytosis elicited by nectins transfers cytoplasmic cargo, including infectious material, between cells. J Cell Sci. 2019;132: pubmed publisher
Buchanan P, Boylan K, Walcheck B, Heinze R, Geller M, Argenta P, et al. Ectodomain shedding of the cell adhesion molecule Nectin-4 in ovarian cancer is mediated by ADAM10 and ADAM17. J Biol Chem. 2017;292:6339-6351 pubmed publisher
Boylan K, Buchanan P, Manion R, Shukla D, Braumberger K, Bruggemeyer C, et al. The expression of Nectin-4 on the surface of ovarian cancer cells alters their ability to adhere, migrate, aggregate, and proliferate. Oncotarget. 2017;8:9717-9738 pubmed publisher
Galanis E, Atherton P, Maurer M, Knutson K, Dowdy S, Cliby W, et al. Oncolytic measles virus expressing the sodium iodide symporter to treat drug-resistant ovarian cancer. Cancer Res. 2015;75:22-30 pubmed publisher
Pavlova N, Pallasch C, Elia A, Braun C, Westbrook T, Hemann M, et al. A role for PVRL4-driven cell-cell interactions in tumorigenesis. elife. 2013;2:e00358 pubmed publisher
DeRycke M, Pambuccian S, Gilks C, Kalloger S, Ghidouche A, Lopez M, et al. Nectin 4 overexpression in ovarian cancer tissues and serum: potential role as a serum biomarker. Am J Clin Pathol. 2010;134:835-45 pubmed publisher

product information

master code :

MAB2659

SKU :

MAB2659

product name :

Human Nectin-4 Antibody

unit size :

100 ug (also 25 ug)

description :

The Human Nectin-4 Antibody from R&D Systems is a mouse monoclonal antibody to Nectin-4/PVRL4. This antibody reacts with human. The Human Nectin-4 Antibody has been validated for the following applications: Immunocytochemistry,Flow Cytometry,Western Blot,Functional Assay,CyTOF-ready.

target :

Nectin-4

category :

Primary Antibodies

buffer :

Lyophilized from a 0.2 ╡m filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 ╡m filtered solution in PBS.

clonality :

Monoclonal

clone :

337516

concentration :

LYOPH

conjugate :

Unconjugated

host :

Mouse

immunogen :

Mouse myeloma cell line NS0-derived recombinant human Nectin-4, Gly27-Val351, Accession # Q96NY8

isotype :

IgG2b

purity :

Protein A or G purified from hybridoma culture supernatant

species :

Human

specificity :

Detects human Nectin-4 in direct ELISAs and Western blots. In direct ELISAs and Western blots, does not cross-react with recombinant human Nectin-1, -2, -3, or recombinant mouse Nectin-4.

gene symbol :

PVRL4

accessionNumbers :

Q96NY8

applications :

Immunocytochemistry,Flow Cytometry,Western Blot,Functional Assay,CyTOF-ready

USD :

489 USD

alt names :

EDSS1, Ig superfamily receptor LNIR, LNIR, LNIRnectin 4, nectin-4, Nectin4, poliovirus receptor-related 4, poliovirus receptor-related protein 4, PRR4, PRR4DKFZp686K05193, PVRL4

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 6 months, -20 to -70 ░C under sterile conditions after reconstitution.

more info or order :

R&D Systems product webpage