product summary
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company name :
R&D Systems
product type :
antibody
product name :
Human Amphiregulin Antibody
catalog :
MAB262-100
quantity :
100 ug (also 25 ug, 500 ug)
price :
479 USD
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
31221
reactivity :
human, mouse
application :
western blot, ELISA, immunocytochemistry, neutralization
more info or order :
R&D Systems product webpage
citations: 19
Reference
Zhao R, Wang Z, Wang G, Geng J, Wu H, Liu X, et al. Sustained amphiregulin expression in intermediate alveolar stem cells drives progressive fibrosis. Cell Stem Cell. 2024;31:1344-1358.e6 pubmed publisher
Miranda A, Kemp J, Davidson B, Bellomo S, Agan V, Manoni A, et al. Genomic dissection and mutation-specific target discovery for breast cancer PIK3CA hotspot mutations. bioRxiv. 2024;: pubmed publisher
Stancil I, Michalski J, Hennessy C, Hatakka K, Yang I, Kurche J, et al. Interleukin-6-dependent epithelial fluidization initiates fibrotic lung remodeling. Sci Transl Med. 2022;14:eabo5254 pubmed publisher
Agaronyan K, Sharma L, Vaidyanathan B, Glenn K, Yu S, Annicelli C, et al. Tissue remodeling by an opportunistic pathogen triggers allergic inflammation. Immunity. 2022;55:895-911.e10 pubmed publisher
Stancil I, Michalski J, Davis Hall D, Chu H, Park J, Magin C, et al. Pulmonary fibrosis distal airway epithelia are dynamically and structurally dysfunctional. Nat Commun. 2021;12:4566 pubmed publisher
Aikin T, Peterson A, Pokrass M, Clark H, Regot S. MAPK activity dynamics regulate non-cell autonomous effects of oncogene expression. elife. 2020;9: pubmed publisher
Davies A, Pargett M, Siebert S, Gillies T, Choi Y, Tobin S, et al. Systems-Level Properties of EGFR-RAS-ERK Signaling Amplify Local Signals to Generate Dynamic Gene Expression Heterogeneity. Cell Syst. 2020;11:161-175.e5 pubmed publisher
Ko J, Kim H, Jeong H, Lee H, Oh J. Mesenchymal Stem and Stromal Cells Harness Macrophage-Derived Amphiregulin to Maintain Tissue Homeostasis. Cell Rep. 2020;30:3806-3820.e6 pubmed publisher
Raimondo S, Saieva L, Vicario E, Pucci M, Toscani D, Manno M, et al. Multiple myeloma-derived exosomes are enriched of amphiregulin (AREG) and activate the epidermal growth factor pathway in the bone microenvironment leading to osteoclastogenesis. J Hematol Oncol. 2019;12:2 pubmed publisher
Walker S, Selfors L, Margolis B, Brugge J. CRB3 and the FERM protein EPB41L4B regulate proliferation of mammary epithelial cells through the release of amphiregulin. PLoS ONE. 2018;13:e0207470 pubmed publisher
Bryant D, Sousounis K, Payzin Dogru D, Bryant S, Sandoval A, Martínez Fernández J, et al. Identification of regenerative roadblocks via repeat deployment of limb regeneration in axolotls. NPJ Regen Med. 2017;2:30 pubmed publisher
Stoll S, Stuart P, Lambert S, Gandarillas A, Rittie L, Johnston A, et al. Membrane-Tethered Intracellular Domain of Amphiregulin Promotes Keratinocyte Proliferation. J Invest Dermatol. 2016;136:444-452 pubmed publisher
Saeki M, Egusa H, Kamano Y, Kakihara Y, Houry W, Yatani H, et al. Exosome-bound WD repeat protein Monad inhibits breast cancer cell invasion by degrading amphiregulin mRNA. PLoS ONE. 2013;8:e67326 pubmed publisher
Tardáguila M, Mira E, García Cabezas M, Feijoo A, Quintela Fandino M, Azcoitia I, et al. CX3CL1 promotes breast cancer via transactivation of the EGF pathway. Cancer Res. 2013;73:4461-73 pubmed publisher
Latasa M, Salis F, Urtasun R, Garcia Irigoyen O, Elizalde M, Uriarte I, et al. Regulation of amphiregulin gene expression by ?-catenin signaling in human hepatocellular carcinoma cells: a novel crosstalk between FGF19 and the EGFR system. PLoS ONE. 2012;7:e52711 pubmed publisher
Lemjabbar Alaoui H, Sidhu S, Mengistab A, Gallup M, Basbaum C. TACE/ADAM-17 phosphorylation by PKC-epsilon mediates premalignant changes in tobacco smoke-exposed lung cells. PLoS ONE. 2011;6:e17489 pubmed publisher
Sisto M, Lisi S, Lofrumento D, Cucci L, Mitolo V, D Amore M. RETRACTED: Blockade of TNF-? signaling suppresses the AREG-mediated IL-6 and IL-8 cytokines secretion induced by anti-Ro/SSA autoantibodies. Lab Invest. 2010;: pubmed
Stoll S, Johnson J, Li Y, Rittie L, Elder J. Amphiregulin carboxy-terminal domain is required for autocrine keratinocyte growth. J Invest Dermatol. 2010;130:2031-40 pubmed publisher
Gonzalez R, Seurynck Servoss S, Crowley S, Brown M, Omenn G, Hayes D, et al. Development and validation of sandwich ELISA microarrays with minimal assay interference. J Proteome Res. 2008;7:2406-14 pubmed publisher
product information
brand :
R&D Systems
master code :
MAB262
SKU :
MAB262-100
product name :
Human Amphiregulin Antibody
unit size :
100 ug (also 25 ug, 500 ug)
seo description :
The Human Amphiregulin Antibody from R&D Systems is a mouse monoclonal antibody to Amphiregulin. This antibody reacts with human,mouse. The Human Amphiregulin Antibody has been validated for the following applications: Neutralization,ELISA Development,ELISA Microarray Development,Immunocytochemistry,Western Blot,ELISA Capture (Matched Antibody Pair).
target :
Amphiregulin
category :
Primary Antibodies
buffer :
Lyophilized from a 0.2 ╡m filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 ╡m filtered solution in PBS.
clonality :
Monoclonal
clone :
31221
conjugate :
Unconjugated
dilution :
Western Blot 1 ug/mL, Neutralization 5-15 ug/mL, ELISA Capture (Matched Antibody Pair) 2-8 ug/mL
host :
Mouse
immunogen :
E. coli -derived recombinant human Amphiregulin
isotype :
IgG1
purity :
Protein A or G purified from hybridoma culture supernatant
species :
Human,Mouse
specificity :
Detects human Amphiregulin (AR) in Western blots. In this format, this antibody shows less than 5% cross-reactivity with recombinant human HB-EGF.
gene symbol :
AREG
endotoxin note :
<0.10 EU per 1 ╡g of the antibody by the LAL method.
top caption :
Cell Proliferation Induced by Amphiregulin and Neutralization by Human Amphiregulin Antibody.
applications :
Western Blot,ELISA Capture (Matched Antibody Pair),ELISA Development,ELISA Microarray Development,Neutralization,Immunocytochemistry
USD :
479 USD
alt names :
amphiregulin, AR, AREG, AREGB, Colorectum cell-derived growth factor, CRDGF, MGC13647, schwannoma-derived growth factor, SDGF
storage :
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 6 months, -20 to -70 ░C under sterile conditions after reconstitution.
more info or order :
R&D Systems product webpage
company information
R&D Systems
614 McKinley Place N.E.
Minneapolis, MN 55413
info@RnDSystems.com
https://www.rndsystems.com
800 343-7475
headquarters: USA
R&D Systems develops and manufactures high-quality proteins and serves as a world leader in immunoassays. R&D Systems also produces quality antibodies, antibody arrays, stem cell and cell culture products, and cell selection and detection products, serving the life science and diagnostics industry.