Human TLR2 Antibody | R&D Systems MAB2616 product information

product summary

company name :

R&D Systems

product type :

antibody

product name :

Human TLR2 Antibody

catalog :

MAB2616

quantity :

100 ug (also 25 ug)

price :

479 USD

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

383936

reactivity :

human, mouse

application :

western blot, immunocytochemistry, neutralization, flow cytometry, immunohistochemistry - paraffin section, blocking or activating experiments

more info or order :

R&D Systems product webpage

citations: 26

Published Application/Species/Sample/Dilution	Reference
blocking or activating experiments; human; 10 ug/ml; loading ...; fig s6d	Hari P, Millar F, Tarrats N, Birch J, Quintanilla A, Rink C, et al. The innate immune sensor Toll-like receptor 2 controls the senescence-associated secretory phenotype. Sci Adv. 2019;5:eaaw0254 pubmed publisher
blocking or activating experiments; human; loading ...; fig 1b	Kativhu C, Libraty D. A Model to Explain How the Bacille Calmette Guérin (BCG) Vaccine Drives Interleukin-12 Production in Neonates. PLoS ONE. 2016;11:e0162148 pubmed publisher
flow cytometry; human; loading ...; fig s1	Sanjurjo L, AmÃ©zaga N, Aran G, Naranjo GÃ³mez M, Arias L, Armengol C, et al. The human CD5L/AIM-CD36 axis: A novel autophagy inducer in macrophages that modulates inflammatory responses. Autophagy. 2015;11:487-502 pubmed publisher
blocking or activating experiments; human	Brummelman J, Veerman R, Hamstra H, Deuss A, Schuijt T, Sloots A, et al. Bordetella pertussis naturally occurring isolates with altered lipooligosaccharide structure fail to fully mature human dendritic cells. Infect Immun. 2015;83:227-38 pubmed publisher
western blot; human	Andersson M, Lutay N, Hallgren O, Westergren Thorsson G, Svensson M, Godaly G. Mycobacterium bovis bacilli Calmette-Guerin regulates leukocyte recruitment by modulating alveolar inflammatory responses. Innate Immun. 2012;18:531-40 pubmed publisher
blocking or activating experiments; human	Lumsden K, Nelson A, Dispenza M, Gilliland K, Cong Z, Zaenglein A, et al. Isotretinoin increases skin-surface levels of neutrophil gelatinase-associated lipocalin in patients treated for severe acne. Br J Dermatol. 2011;165:302-10 pubmed publisher
	Decout A, Krasias I, Roberts L, Gimeno Molina B, Charenton C, Brown Romero D, et al. Lactobacillus crispatus S-layer proteins modulate innate immune response and inflammation in the lower female reproductive tract. Nat Commun. 2024;15:10879 pubmed publisher
	Zhao S, Si M, Deng X, Wang D, Kong L, Zhang Q. HCV inhibits M2a, M2b and M2c macrophage polarization via HCV core protein engagement with Toll-like receptor 2. Exp Ther Med. 2022;24:522 pubmed publisher
	Sung P, Yang S, Peng Y, Sun C, Tao M, Hsieh S. CLEC5A and TLR2 are critical in SARS-CoV-2-induced NET formation and lung inflammation. J Biomed Sci. 2022;29:52 pubmed publisher
	Li T, Yang Y, Li Y, Wang Z, Ma F, Luo R, et al. Platelets mediate inflammatory monocyte activation by SARS-CoV-2 spike protein. J Clin Invest. 2022;132: pubmed publisher
	Zheng M, Ambesi A, McKeown Longo P. Role of TLR4 Receptor Complex in the Regulation of the Innate Immune Response by Fibronectin. Cells. 2020;9: pubmed publisher
	Øya E, Becher R, Ekeren L, Afanou A, Øvrevik J, Holme J. Pro-Inflammatory Responses in Human Bronchial Epithelial Cells Induced by Spores and Hyphal Fragments of Common Damp Indoor Molds. Int J Environ Res Public Health. 2019;16: pubmed publisher
	Song H, Tan G, Yang Y, Cui A, Li H, Li T, et al. Hepatitis B Virus-Induced Imbalance of Inflammatory and Antiviral Signaling by Differential Phosphorylation of STAT1 in Human Monocytes. J Immunol. 2019;202:2266-2275 pubmed publisher
	Chen S, Li F, Hsu T, Liang S, Yeh Y, Liao W, et al. CLEC5A is a critical receptor in innate immunity against Listeria infection. Nat Commun. 2017;8:299 pubmed publisher
	Sharma R, Ghasparian A, Robinson J, McCullough K. Dendritic Cell Sensing of Hydrophobic Di- and Triacylated Lipopeptides Self-Assembled within Synthetic Virus-like Particles. J Immunol. 2017;199:734-749 pubmed publisher
	Tóth A, Zajta E, Csonka K, Vagvolgyi C, Netea M, Gacser A. Specific pathways mediating inflammasome activation by Candida parapsilosis. Sci Rep. 2017;7:43129 pubmed publisher
	Smith I, Baker A, Christensen J, Boekhout T, Frøkiær H, Arneborg N, et al. Kluyveromyces marxianus and Saccharomyces boulardii Induce Distinct Levels of Dendritic Cell Cytokine Secretion and Significantly Different T Cell Responses In Vitro. PLoS ONE. 2016;11:e0167410 pubmed publisher
	Hoonakker M, Verhagen L, Pupo E, de Haan A, Metz B, Hendriksen C, et al. Vaccine-Mediated Activation of Human TLR4 Is Affected by Modulation of Culture Conditions during Whole-Cell Pertussis Vaccine Preparation. PLoS ONE. 2016;11:e0161428 pubmed publisher
	Ganesan S, Pham D, Jing Y, Farazuddin M, Hudy M, Unger B, et al. TLR2 Activation Limits Rhinovirus-Stimulated CXCL-10 by Attenuating IRAK-1-Dependent IL-33 Receptor Signaling in Human Bronchial Epithelial Cells. J Immunol. 2016;197:2409-20 pubmed publisher
	Waller T, Kesper L, Hirschfeld J, Dommisch H, KÃ¶lpin J, Oldenburg J, et al. Porphyromonas gingivalis Outer Membrane Vesicles Induce Selective Tumor Necrosis Factor Tolerance in a Toll-Like Receptor 4- and mTOR-Dependent Manner. Infect Immun. 2016;84:1194-1204 pubmed publisher
	Vogel S, BÃ¶rger V, Peters C, FÃ¶rster M, Liebfried P, Metzger K, et al. Necrotic cell-derived high mobility group box 1 attracts antigen-presenting cells but inhibits hepatocyte growth factor-mediated tropism of mesenchymal stem cells for apoptotic cell death. Cell Death Differ. 2015;22:1219-30 pubmed publisher
	Park S, Lee S, Kim H, Lee W, Hong K, Kim C. HMGB1 induces angiogenesis in rheumatoid arthritis via HIF-1Î± activation. Eur J Immunol. 2015;45:1216-27 pubmed publisher
	Vogel S, Chatterjee M, Metzger K, Borst O, Geisler T, Seizer P, et al. Activated platelets interfere with recruitment of mesenchymal stem cells to apoptotic cardiac cells via high mobility group box 1/Toll-like receptor 4-mediated down-regulation of hepatocyte growth factor receptor MET. J Biol Chem. 2014;289:11068-82 pubmed publisher
	Lutay N, Håkansson G, Alaridah N, Hallgren O, Westergren Thorsson G, Godaly G. Mycobacteria bypass mucosal NF-kB signalling to induce an epithelial anti-inflammatory IL-22 and IL-10 response. PLoS ONE. 2014;9:e86466 pubmed publisher
	Li D, Wang X, Wu J, Quan W, Ma L, Yang F, et al. Tumor-produced versican V1 enhances hCAP18/LL-37 expression in macrophages through activation of TLR2 and vitamin D3 signaling to promote ovarian cancer progression in vitro. PLoS ONE. 2013;8:e56616 pubmed publisher
	Zunt S, Burton L, Goldblatt L, Dobbins E, Srinivasan M. Soluble forms of Toll-like receptor 4 are present in human saliva and modulate tumour necrosis factor-alpha secretion by macrophage-like cells. Clin Exp Immunol. 2009;156:285-93 pubmed publisher

product information

master code :

MAB2616

SKU :

MAB2616

product name :

Human TLR2 Antibody

unit size :

100 ug (also 25 ug)

description :

The Human TLR2 Antibody from R&D Systems is a mouse monoclonal antibody to TLR2. This antibody reacts with human,mouse,porcine. The Human TLR2 Antibody has been validated for the following applications: Neutralization,Blocking,ELISA Development,Flow Cytometry,Western Blot,Functional Assay,Immunohistochemistry-Paraffin,Immunocytochemistry,CyTOF-ready.

target :

TLR2

category :

Primary Antibodies

buffer :

Lyophilized from a 0.2 ╡m filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 ╡m filtered solution in PBS.

clonality :

Monoclonal

clone :

383936

concentration :

LYOPH

conjugate :

Unconjugated

host :

Mouse

immunogen :

NS0 mouse myeloma cell line transfected with human TLR2, Accession # O60603

isotype :

IgG2b

purity :

Protein A or G purified from hybridoma culture supernatant

species :

Human,Mouse,Porcine

specificity :

Stains human TLR2 transfectants but not irrelevant transfectants.

gene symbol :

TLR2

endotoxin note :

<0.10 EU per 1 ╡g of the antibody by the LAL method.

top caption :

IL-8 Secretion Induced by Pam3CSK4and Neutralization by Human TLR2 Antibody.

accessionNumbers :

O60603

applications :

Neutralization,Blocking,ELISA Development,Flow Cytometry,Western Blot,Functional Assay,Immunohistochemistry-Paraffin,Immunocytochemistry,CyTOF-ready

USD :

479 USD

alt names :

CD282, CD282 antigen, TIL4CD282, toll/interleukin 1 receptor-like 4, Toll/interleukin-1 receptor-like protein 4, toll-like receptor 2

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 6 months, -20 to -70 ░C under sterile conditions after reconstitution.

more info or order :

R&D Systems product webpage