product summary
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company name :
R&D Systems
product type :
antibody
product name :
Human beta-NGF Antibody
catalog :
MAB256-100
quantity :
100 ug (also 25 ug, 500 ug)
price :
489 USD
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
25623
reactivity :
human, mouse
application :
western blot, ELISA, immunocytochemistry, neutralization, immunohistochemistry - paraffin section
more info or order :
R&D Systems product webpage
citations: 12
Reference
Song L, Tian X, Schekman R. Extracellular vesicles from neurons promote neural induction of stem cells through cyclin D1. J Cell Biol. 2021;220: pubmed publisher
Balzamino B, Esposito G, Marino R, Keller F, Micera A. Changes in vitreal protein profile and retina mRNAs in Reeler mice: NGF, IL33 and Müller cell activation. PLoS ONE. 2019;14:e0212732 pubmed publisher
Kolli S, Bojic S, Ghareeb A, Kurzawa Akanbi M, Figueiredo F, Lako M. The Role of Nerve Growth Factor in Maintaining Proliferative Capacity, Colony-Forming Efficiency, and the Limbal Stem Cell Phenotype. Stem Cells. 2019;37:139-149 pubmed publisher
Tiwari N, Pataskar A, Peron S, Thakurela S, Sahu S, Figueres Oñate M, et al. Stage-Specific Transcription Factors Drive Astrogliogenesis by Remodeling Gene Regulatory Landscapes. Cell Stem Cell. 2018;23:557-571.e8 pubmed publisher
Kisiswa L, Fernández Suárez D, Sergaki M, Ibanez C. RIP2 Gates TRAF6 Interaction with Death Receptor p75NTR to Regulate Cerebellar Granule Neuron Survival. Cell Rep. 2018;24:1013-1024 pubmed publisher
Oddone F, Roberti G, Micera A, Busanello A, Bonini S, Quaranta L, et al. Exploring Serum Levels of Brain Derived Neurotrophic Factor and Nerve Growth Factor Across Glaucoma Stages. PLoS ONE. 2017;12:e0168565 pubmed publisher
Malerba F, Paoletti F, Cattaneo A. NGF and proNGF Reciprocal Interference in Immunoassays: Open Questions, Criticalities, and Ways Forward. Front Mol Neurosci. 2016;9:63 pubmed publisher
Malerba F, Paoletti F, Bruni Ercole B, Materazzi S, Nassini R, Coppi E, et al. Functional Characterization of Human ProNGF and NGF Mutants: Identification of NGF P61SR100E as a "Painless" Lead Investigational Candidate for Therapeutic Applications. PLoS ONE. 2015;10:e0136425 pubmed publisher
Lambiase A, Micera A, Sacchetti M, Cortes M, Mantelli F, Bonini S. Alterations of tear neuromediators in dry eye disease. Arch Ophthalmol. 2011;129:981-6 pubmed publisher
Samah B, Porcheray F, Gras G. Neurotrophins modulate monocyte chemotaxis without affecting macrophage function. Clin Exp Immunol. 2008;151:476-86 pubmed publisher
Quarcoo D, Schulte Herbrüggen O, Lommatzsch M, Schierhorn K, Hoyle G, Renz H, et al. Nerve growth factor induces increased airway inflammation via a neuropeptide-dependent mechanism in a transgenic animal model of allergic airway inflammation. Clin Exp Allergy. 2004;34:1146-51 pubmed
Dollé L, El Yazidi Belkoura I, Adriaenssens E, Nurcombe V, Hondermarck H. Nerve growth factor overexpression and autocrine loop in breast cancer cells. Oncogene. 2003;22:5592-601 pubmed
product information
brand :
R&D Systems
master code :
MAB256
SKU :
MAB256-100
product name :
Human beta-NGF Antibody
unit size :
100 ug (also 25 ug, 500 ug)
seo description :
The Human beta-NGF Antibody from R&D Systems is a mouse monoclonal antibody to beta-NGF. This antibody reacts with human,mouse,transgenic mouse. The Human beta-NGF Antibody has been validated for the following applications: ELISA Development,Western Blot,Surface Plasmon Resonance,Neutralization,Immunohistochemistry-Paraffin,Immunocytochemistry,ELISA Capture (Matched Antibody Pair).
target :
beta-NGF
category :
Primary Antibodies
buffer :
Lyophilized from a 0.2 ╡m filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 ╡m filtered solution in PBS.
clonality :
Monoclonal
clone :
25623
conjugate :
Unconjugated
dilution :
Neutralization 0.1-0.4 ug/mL, ELISA Capture (Matched Antibody Pair) 2-8 ug/mL
host :
Mouse
immunogen :
Mouse myeloma cell line NS0-derived recombinant human ▀-NGF, Ser122-Ala241, Accession # CAA36832
isotype :
IgG1
purity :
Protein A or G purified from hybridoma culture supernatant
species :
Human,Mouse,Transgenic Mouse
specificity :
Detects human ▀-NGF in ELISAs. In direct ELISAs, 100% cross-reactivity with recombinant mouse (rm) ▀-NGF and recombinant rat (rr) ▀-NGF is observed and less than 5% cross-reactivity with recombinant human (rh) BDNF, rhNT-3, and rhNT-4 is observed. This antibody neutralizes the bioactivity of rh▀-NGF, rm▀-NGF, and rr▀-NGF.
gene symbol :
NGF
endotoxin note :
<0.10 EU per 1 ╡g of the antibody by the LAL method.
top caption :
Cell Proliferation Induced by ss-NGF and Neutralization by Human ss-NGF Antibody.
accessionNumbers :
CAA36832
applications :
ELISA Capture (Matched Antibody Pair),ELISA Development,Western Blot,Immunohistochemistry-Paraffin,Surface Plasmon Resonance,Neutralization,Immunocytochemistry
USD :
489 USD
alt names :
Beta nerve growth factor precursor, beta-nerve growth factor, betaNGF, Beta-NGF, HSAN5, MGC161426, nerve growth factor (beta polypeptide), nerve growth factor, beta subunit, NGFB, NGFBMGC161428
storage :
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 6 months, -20 to -70 ░C under sterile conditions after reconstitution.
more info or order :
R&D Systems product webpage
company information
R&D Systems
614 McKinley Place N.E.
Minneapolis, MN 55413
info@RnDSystems.com
https://www.rndsystems.com
800 343-7475
headquarters: USA
R&D Systems develops and manufactures high-quality proteins and serves as a world leader in immunoassays. R&D Systems also produces quality antibodies, antibody arrays, stem cell and cell culture products, and cell selection and detection products, serving the life science and diagnostics industry.