product summary
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company name :
R&D Systems
product type :
antibody
product name :
Human Osteoactivin/GPNMB Antibody
catalog :
MAB25501
quantity :
100 ug (also 25 ug)
price :
489 USD
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
303822
reactivity :
human, mouse
application :
western blot, immunohistochemistry, immunocytochemistry, flow cytometry, immunohistochemistry - frozen section
more info or order :
R&D Systems product webpage
citations: 5
Reference
Lin Y, Qi Y, Jiang M, Huang W, Li B. Lactic acid-induced M2-like macrophages facilitate tumor cell migration and invasion via the GPNMB/CD44 axis in oral squamous cell carcinoma. Int Immunopharmacol. 2023;124:110972 pubmed publisher
Kramer G, Wegdam W, Donker Koopman W, Ottenhoff R, Gaspar P, Verhoek M, et al. Elevation of glycoprotein nonmetastatic melanoma protein B in type 1 Gaucher disease patients and mouse models. FEBS Open Bio. 2016;6:902-13 pubmed publisher
Gutknecht M, Geiger J, Joas S, Dörfel D, Salih H, Müller M, et al. The transcription factor MITF is a critical regulator of GPNMB expression in dendritic cells. Cell Commun Signal. 2015;13:19 pubmed publisher
Fiorentini C, Bodei S, Bedussi F, Fragni M, Bonini S, Simeone C, et al. GPNMB/OA protein increases the invasiveness of human metastatic prostate cancer cell lines DU145 and PC3 through MMP-2 and MMP-9 activity. Exp Cell Res. 2014;323:100-11 pubmed publisher
Qin C, Liu Z, Yuan Y, Zhang X, Li H, Zhang C, et al. Glycoprotein non-metastatic melanoma protein B as a predictive prognostic factor in clear-cell renal cell carcinoma following radical nephrectomy. Mol Med Rep. 2014;9:851-6 pubmed publisher
product information
brand :
R&D Systems
master code :
MAB25501
SKU :
MAB25501
product name :
Human Osteoactivin/GPNMB Antibody
unit size :
100 ug (also 25 ug)
seo description :
The Human Osteoactivin/GPNMB Antibody from R&D Systems is a mouse monoclonal antibody to Osteoactivin/GPNMB. This antibody reacts with human,mouse. The Human Osteoactivin/GPNMB Antibody has been validated for the following applications: Flow Cytometry,Western Blot,Immunohistochemistry,Immunohistochemistry-Frozen,Immunocytochemistry,Intracellular Staining by Flow Cytometry,CyTOF-ready.
target :
Osteoactivin/GPNMB
category :
Primary Antibodies
buffer :
Lyophilized from a 0.2 ╡m filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 ╡m filtered solution in PBS.
clonality :
Monoclonal
clone :
303822
concentration :
LYOPH
conjugate :
Unconjugated
dilution :
Western Blot 1 ug/mL, Intracellular Staining by Flow Cytometry 0.25 ug/10^6 cells, Immunocytochemistry 8-25 ug/mL, CyTOF-ready
host :
Mouse
immunogen :
Mouse myeloma cell line NS0-derived recombinant human Osteoactivin/GPNMB isoform 2, Ala22-Asn486, Accession # NP_002501
isotype :
IgG2b
purity :
Protein A or G purified from hybridoma culture supernatant
species :
Human,Mouse
specificity :
Detects human Osteoactivin/GPNMB in direct ELISAs and Western blots. In direct ELISAs, no cross-reactivity with recombinant mouse Osteoactivin is observed.
gene symbol :
GPNMB
top caption :
Detection of Osteoactivin/GPNMB antibody in MG-63 Human Cell Line antibody by Flow Cytometry.
accessionNumbers :
NP_002501
applications :
Intracellular Staining by Flow Cytometry,CyTOF-ready,Flow Cytometry,Immunohistochemistry,Western Blot,Immunohistochemistry-Frozen,Immunocytochemistry
USD :
489 USD
alt names :
DC-HIL, glycoprotein (transmembrane) nmb, glycoprotein NMB, GPNMB, HGFIN, HGFINglycoprotein nmb-like protein, NMBosteoactivin, Transmembrane glycoprotein HGFIN, transmembrane glycoprotein NMB
storage :
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 6 months, -20 to -70 ░C under sterile conditions after reconstitution.
more info or order :
R&D Systems product webpage
company information
R&D Systems
614 McKinley Place N.E.
Minneapolis, MN 55413
info@RnDSystems.com
https://www.rndsystems.com
800 343-7475
headquarters: USA
R&D Systems develops and manufactures high-quality proteins and serves as a world leader in immunoassays. R&D Systems also produces quality antibodies, antibody arrays, stem cell and cell culture products, and cell selection and detection products, serving the life science and diagnostics industry.