Human Phospho-DDR1/DDR2 (DDR1 Y796, DDR2 Y740) Antibody | R&D Systems MAB25382 product information

product summary

company name :

R&D Systems

product type :

antibody

product name :

Human Phospho-DDR1/DDR2 (DDR1 Y796, DDR2 Y740) Antibody

catalog :

MAB25382

quantity :

100 ug (also 25 ug)

price :

489 USD

clonality :

monoclonal

host :

domestic rabbit

conjugate :

nonconjugated

clone name :

1119D

reactivity :

human, mouse

application :

western blot, immunohistochemistry, immunocytochemistry

more info or order :

R&D Systems product webpage

citations: 15

Reference
Zhou T, C Cavalcante R, Ge C, Franceschi R, Ma P. Synthetic helical peptides on nanofibers to activate cell-surface receptors and synergistically enhance critical-sized bone defect regeneration. Bioact Mater. 2025;43:98-113 pubmed publisher
Mohamed F, Ge C, Hallett S, Bancroft A, Cowling R, Ono N, et al. Control of craniofacial development by the collagen receptor, discoidin domain receptor 2. elife. 2023;12: pubmed publisher
Pagani C, Bancroft A, Tower R, Livingston N, Sun Y, Hong J, et al. Discoidin domain receptor 2 regulates aberrant mesenchymal lineage cell fate and matrix organization. Sci Adv. 2022;8:eabq6152 pubmed publisher
Sala M, Allain N, Moreau M, Jabouille A, Henriet E, Abou Hammoud A, et al. Discoidin Domain Receptor 2 orchestrates melanoma resistance combining phenotype switching and proliferation. Oncogene. 2022;41:2571-2586 pubmed publisher
Barcus C, Hwang P, Morikis V, Brenot A, Pence P, Clarke M, et al. Tyrosine kinase-independent actions of DDR2 in tumor cells and cancer-associated fibroblasts influence tumor invasion, migration and metastasis. J Cell Sci. 2021;134: pubmed publisher
Hinz N, Baranowsky A, Horn M, Kriegs M, Sibbertsen F, Smit D, et al. Knockdown of AKT3 Activates HER2 and DDR Kinases in Bone-Seeking Breast Cancer Cells, Promotes Metastasis In Vivo and Attenuates the TGFβ/CTGF Axis. Cells. 2021;10: pubmed publisher
Lin C, Yang W, Lin Y, Tang X, Chen P, Ding C, et al. DDR2 upregulation confers ferroptosis susceptibility of recurrent breast tumors through the Hippo pathway. Oncogene. 2021;40:2018-2034 pubmed publisher
Sammon D, Hohenester E, Leitinger B. Two-step release of kinase autoinhibition in discoidin domain receptor 1. Proc Natl Acad Sci U S A. 2020;117:22051-22060 pubmed publisher
Jalan A, Sammon D, Hartgerink J, Brear P, Stott K, Hamaia S, et al. Chain alignment of collagen I deciphered using computationally designed heterotrimers. Nat Chem Biol. 2020;16:423-429 pubmed publisher
Corcoran D, Juskaite V, Xu Y, Görlitz F, Alexandrov Y, Dunsby C, et al. DDR1 autophosphorylation is a result of aggregation into dense clusters. Sci Rep. 2019;9:17104 pubmed publisher
Slocum E, Craig A, Villanueva A, Germain D. Parity predisposes breasts to the oncogenic action of PAPP-A and activation of the collagen receptor DDR2. Breast Cancer Res. 2019;21:56 pubmed publisher
Yeung D, Shanker N, Sohail A, Weiss B, Wang C, Wellmerling J, et al. Clustering, Spatial Distribution, and Phosphorylation of Discoidin Domain Receptors 1 and 2 in Response to Soluble Collagen I. J Mol Biol. 2019;431:368-390 pubmed publisher
Xu L, Jensen H, Johnston J, Di Maria E, Kloth K, Cristea I, et al. Recurrent, Activating Variants in the Receptor Tyrosine Kinase DDR2 Cause Warburg-Cinotti Syndrome. Am J Hum Genet. 2018;103:976-983 pubmed publisher
Gonzalez M, Martin E, Anwar T, Arellano Garcia C, Medhora N, Lama A, et al. Mesenchymal Stem Cell-Induced DDR2 Mediates Stromal-Breast Cancer Interactions and Metastasis Growth. Cell Rep. 2017;18:1215-1228 pubmed publisher
Xie B, Lin W, Ye J, Wang X, Zhang B, Xiong S, et al. DDR2 facilitates hepatocellular carcinoma invasion and metastasis via activating ERK signaling and stabilizing SNAIL1. J Exp Clin Cancer Res. 2015;34:101 pubmed publisher

product information

master code :

MAB25382

SKU :

MAB25382

product name :

Human Phospho-DDR1/DDR2 (DDR1 Y796, DDR2 Y740) Antibody

unit size :

100 ug (also 25 ug)

description :

The Human Phospho-DDR1/DDR2 (DDR1 Y796, DDR2 Y740) Antibody from R&D Systems is a rabbit monoclonal antibody to DDR1/DDR2. This antibody reacts with human,mouse,primate - cercopithecus aethiops (african green monkey). The Human Phospho-DDR1/DDR2 (DDR1 Y796, DDR2 Y740) Antibody has been validated for the following applications: Immunohistochemistry,Immunocytochemistry,Western Blot,Simple Western.

target :

DDR1/DDR2

category :

Primary Antibodies

buffer :

Lyophilized from a 0.2 ╡m filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 ╡m filtered solution in PBS.

clonality :

Monoclonal

clone :

1119D

conjugate :

Unconjugated

host :

Rabbit

immunogen :

Phosphopeptide containing the human DDR2 Y740 site, Accession # Q16832

isotype :

IgG

purity :

Protein A or G purified from cell culture supernatant

species :

Human,Mouse,Primate - Cercopithecus aethiops (African Green Monkey)

specificity :

Detects human DDR1 and DDR2 when phosphorylated at Y796 and Y740.

gene symbol :

DDR2

top caption :

Detection of Human Phospho-DDR2 (Y740) antibody by Western Blot.

accessionNumbers :

Q16832

applications :

Immunohistochemistry,Immunocytochemistry,Western Blot,Simple Western

extended description :

Recombinant Monoclonal Antibody.

USD :

489 USD

product details :

Recombinant Monoclonal Antibody.

alt names :

6030432F18;AI323681;CAK;CD167;CD167a;DDR;DDR1;Drd1;EDDR1;HGK2;MCK10;Mpk6;NEP;NTRK4;PTK3;PTK3A;PTK3D;RTK6;TRKE, CAK, CD167a, RTK6, TKT, Trk3, TrkE, Tyro-10

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 6 months, -20 to -70 ░C under sterile conditions after reconstitution.

more info or order :

R&D Systems product webpage