CFTR C-Terminus Antibody | R&D Systems MAB25031 product information

product summary

company name :

R&D Systems

product type :

antibody

product name :

CFTR C-Terminus Antibody

catalog :

MAB25031

quantity :

50 ug (also 25 ug)

price :

351 USD

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

24-1

reactivity :

human

application :

western blot, immunohistochemistry, immunoprecipitation

more info or order :

R&D Systems product webpage

citations: 47

Published Application/Species/Sample/Dilution	Reference
immunohistochemistry; human; loading ...; fig s2-2c	Hendley A, Rao A, Leonhardt L, Ashe S, Smith J, Giacometti S, et al. Single-cell transcriptome analysis defines heterogeneity of the murine pancreatic ductal tree. elife. 2021;10: pubmed publisher
	Snow S, Matkowskyj K, Maresh M, Clipson L, Vo T, Johnson K, et al. Validation of genetic classifiers derived from mouse and human tumors to identify molecular subtypes of colorectal cancer. Hum Pathol. 2022;119:1-14 pubmed publisher
	Kumar P, Soni D, Sen C, Larsen M, Mazan Mamczarz K, Piao Y, et al. SFPQ rescues F508del-CFTR expression and function in cystic fibrosis bronchial epithelial cells. Sci Rep. 2021;11:16645 pubmed publisher
	Badaoui M, Zoso A, Idris T, Bacchetta M, Simonin J, Lemeille S, et al. Vav3 Mediates Pseudomonas aeruginosa Adhesion to the Cystic Fibrosis Airway Epithelium. Cell Rep. 2020;32:107842 pubmed publisher
	Rehman T, Thornell I, Pezzulo A, Thurman A, Romano Ibarra G, Karp P, et al. TNFα and IL-17 alkalinize airway surface liquid through CFTR and pendrin. Am J Physiol Cell Physiol. 2020;319:C331-C344 pubmed publisher
	Favia M, Gallo C, Guerra L, De Venuto D, Diana A, Polizzi A, et al. Treatment of Cystic Fibrosis Patients Homozygous for F508del with Lumacaftor-Ivacaftor (Orkambi®) Restores Defective CFTR Channel Function in Circulating Mononuclear Cells. Int J Mol Sci. 2020;21: pubmed publisher
	Ortiz Muñoz G, Yu M, Lefrançais E, Mallavia B, Valet C, Tian J, et al. Cystic fibrosis transmembrane conductance regulator dysfunction in platelets drives lung hyperinflammation. J Clin Invest. 2020;130:2041-2053 pubmed publisher
	BORCHERDING D, Siefert M, Lin S, Brewington J, Sadek H, Clancy J, et al. Clinically-approved CFTR modulators rescue Nrf2 dysfunction in cystic fibrosis airway epithelia. J Clin Invest. 2019;129:3448-3463 pubmed publisher
	Malakpour Kolbadinezhad S, Coimbra J, Wilson J. Effect of dendritic organ ligation on striped eel catfish Plotosus lineatus osmoregulation. PLoS ONE. 2018;13:e0206206 pubmed publisher
	De Rocco D, Pompili B, Castellani S, Morini E, Cavinato L, Cimino G, et al. Assembly and Functional Analysis of an S/MAR Based Episome with the Cystic Fibrosis Transmembrane Conductance Regulator Gene. Int J Mol Sci. 2018;19: pubmed publisher
	Schögler A, Blank F, Brügger M, Beyeler S, Tschanz S, Regamey N, et al. Characterization of pediatric cystic fibrosis airway epithelial cell cultures at the air-liquid interface obtained by non-invasive nasal cytology brush sampling. Respir Res. 2017;18:215 pubmed publisher
	Shrestha C, Assani K, Rinehardt H, Albastroiu F, Zhang S, Shell R, et al. Cysteamine-mediated clearance of antibiotic-resistant pathogens in human cystic fibrosis macrophages. PLoS ONE. 2017;12:e0186169 pubmed publisher
	Figueira M, Castiglione R, de Lemos Barbosa C, Ornellas F, da Silva Feltran G, Morales M, et al. Diabetic rats present higher urinary loss of proteins and lower renal expression of megalin, cubilin, ClC-5, and CFTR. Physiol Rep. 2017;5: pubmed publisher
	Chen X, Zhang B, Chng Y, Ong J, Chew S, Wong W, et al. Ammonia exposure affects the mRNA and protein expression levels of certain Rhesus glycoproteins in the gills of climbing perch. J Exp Biol. 2017;220:2916-2931 pubmed publisher
	Bozoky Z, Ahmadi S, Milman T, Kim T, Du K, Di Paola M, et al. Synergy of cAMP and calcium signaling pathways in CFTR regulation. Proc Natl Acad Sci U S A. 2017;114:E2086-E2095 pubmed publisher
	Pankow S, Bamberger C, Calzolari D, Bamberger A, Yates J. Deep interactome profiling of membrane proteins by co-interacting protein identification technology. Nat Protoc. 2016;11:2515-2528 pubmed publisher
	Rocca J, Manin S, Hulin A, Aissat A, Verbecq Morlot W, Prulière Escabasse V, et al. New use for an old drug: COX-independent anti-inflammatory effects of sulindac in models of cystic fibrosis. Br J Pharmacol. 2016;173:1728-41 pubmed publisher
	Tabeling C, Yu H, Wang L, Ranke H, Goldenberg N, Zabini D, et al. CFTR and sphingolipids mediate hypoxic pulmonary vasoconstriction. Proc Natl Acad Sci U S A. 2015;112:E1614-23 pubmed publisher
	Ferru ClÃ©ment R, Fresquet F, Norez C, MÃ©tayÃ© T, Becq F, Kitzis A, et al. Involvement of the Cdc42 pathway in CFTR post-translational turnover and in its plasma membrane stability in airway epithelial cells. PLoS ONE. 2015;10:e0118943 pubmed publisher
	Caohuy H, Yang Q, Eudy Y, Ha T, Xu A, Glover M, et al. Activation of 3-phosphoinositide-dependent kinase 1 (PDK1) and serum- and glucocorticoid-induced protein kinase 1 (SGK1) by short-chain sphingolipid C4-ceramide rescues the trafficking defect of Î”F508-cystic fibrosis transmembrane conductance regulat. J Biol Chem. 2014;289:35953-68 pubmed publisher
	Hassan F, Xu X, Nuovo G, Killilea D, Tyrrell J, Da Tan C, et al. Accumulation of metals in GOLD4 COPD lungs is associated with decreased CFTR levels. Respir Res. 2014;15:69 pubmed publisher
	Carbone A, Castellani S, Favia M, Diana A, Paracchini V, Di Gioia S, et al. Correction of defective CFTR/ENaC function and tightness of cystic fibrosis airway epithelium by amniotic mesenchymal stromal (stem) cells. J Cell Mol Med. 2014;18:1631-43 pubmed publisher
	Losa D, Köhler T, Bellec J, Dudez T, Crespin S, Bacchetta M, et al. Pseudomonas aeruginosa-induced apoptosis in airway epithelial cells is mediated by gap junctional communication in a JNK-dependent manner. J Immunol. 2014;192:4804-12 pubmed publisher
	Li Z, Lui E, Wilson J, Ip Y, Lin Q, Lam T, et al. Expression of key ion transporters in the gill and esophageal-gastrointestinal tract of euryhaline Mozambique tilapia Oreochromis mossambicus acclimated to fresh water, seawater and hypersaline water. PLoS ONE. 2014;9:e87591 pubmed publisher
	Cebotaru L, Rapino D, Cebotaru V, Guggino W. Correcting the cystic fibrosis disease mutant, A455E CFTR. PLoS ONE. 2014;9:e85183 pubmed publisher
	El Khouri E, Le Pavec G, Toledano M, Delaunay Moisan A. RNF185 is a novel E3 ligase of endoplasmic reticulum-associated degradation (ERAD) that targets cystic fibrosis transmembrane conductance regulator (CFTR). J Biol Chem. 2013;288:31177-91 pubmed publisher
	Viart V, Varilh J, Lopez E, René C, Claustres M, Taulan Cadars M. Phosphorylated C/EBP? influences a complex network involving YY1 and USF2 in lung epithelial cells. PLoS ONE. 2013;8:e60211 pubmed publisher
	Oglesby I, Chotirmall S, McElvaney N, Greene C. Regulation of cystic fibrosis transmembrane conductance regulator by microRNA-145, -223, and -494 is altered in ?F508 cystic fibrosis airway epithelium. J Immunol. 2013;190:3354-62 pubmed publisher
	Duan Y, Sun Y, Zhang F, Zhang W, Wang D, Wang Y, et al. Keratin K18 increases cystic fibrosis transmembrane conductance regulator (CFTR) surface expression by binding to its C-terminal hydrophobic patch. J Biol Chem. 2012;287:40547-59 pubmed publisher
	Murphy S, Lim R, Heraud P, Cholewa M, Le Gros M, de Jonge M, et al. Human amnion epithelial cells induced to express functional cystic fibrosis transmembrane conductance regulator. PLoS ONE. 2012;7:e46533 pubmed publisher
	King J, Lee J, Riemen C, Neumann D, Xiong S, Foskett J, et al. Role of binding and nucleoside diphosphate kinase A in the regulation of the cystic fibrosis transmembrane conductance regulator by AMP-activated protein kinase. J Biol Chem. 2012;287:33389-400 pubmed publisher
	Teng L, Kerbiriou M, Taiya M, le Hir S, Mignen O, Benz N, et al. Proteomic identification of calumenin as a G551D-CFTR associated protein. PLoS ONE. 2012;7:e40173 pubmed publisher
	Sorio C, Buffelli M, Angiari C, Ettorre M, Johansson J, Vezzalini M, et al. Defective CFTR expression and function are detectable in blood monocytes: development of a new blood test for cystic fibrosis. PLoS ONE. 2011;6:e22212 pubmed publisher
	Fouassier L, Rosenberg P, Mergey M, Saubamea B, Clapéron A, Kinnman N, et al. Ezrin-radixin-moesin-binding phosphoprotein (EBP50), an estrogen-inducible scaffold protein, contributes to biliary epithelial cell proliferation. Am J Pathol. 2009;174:869-80 pubmed publisher
	Cebotaru L, Vij N, Ciobanu I, Wright J, Flotte T, Guggino W. Cystic fibrosis transmembrane regulator missing the first four transmembrane segments increases wild type and DeltaF508 processing. J Biol Chem. 2008;283:21926-33 pubmed publisher
	Shead E, Haworth C, Condliffe A, McKeon D, Scott M, Compston J. Cystic fibrosis transmembrane conductance regulator (CFTR) is expressed in human bone. Thorax. 2007;62:650-1 pubmed
	Robert R, Savineau J, Norez C, Becq F, Guibert C. Expression and function of cystic fibrosis transmembrane conductance regulator in rat intrapulmonary arteries. Eur Respir J. 2007;30:857-64 pubmed
	Madsen S, Jensen L, Tipsmark C, Kiilerich P, Borski R. Differential regulation of cystic fibrosis transmembrane conductance regulator and Na+,K+ -ATPase in gills of striped bass, Morone saxatilis: effect of salinity and hormones. J Endocrinol. 2007;192:249-60 pubmed
	Tang J, Wong C, Au D. The ichthyotoxic alga Chattonella marina induces Na+, K+ -ATPase, and CFTR proteins expression in fish gill chloride cells in vivo. Biochem Biophys Res Commun. 2007;353:98-103 pubmed
	Painter R, Valentine V, Lanson N, Leidal K, Zhang Q, Lombard G, et al. CFTR Expression in human neutrophils and the phagolysosomal chlorination defect in cystic fibrosis. Biochemistry. 2006;45:10260-9 pubmed
	Nanua S, Sajjan U, Keshavjee S, Hershenson M. Absence of typical unfolded protein response in primary cultured cystic fibrosis airway epithelial cells. Biochem Biophys Res Commun. 2006;343:135-43 pubmed
	Davidson H, McLachlan G, Wilson A, Boyd A, Doherty A, MacGregor G, et al. Human-specific cystic fibrosis transmembrane conductance regulator antibodies detect in vivo gene transfer to ovine airways. Am J Respir Cell Mol Biol. 2006;35:72-83 pubmed
	Clain J, Lehmann Che J, Duguépéroux I, Arous N, Girodon E, Legendre M, et al. Misprocessing of the CFTR protein leads to mild cystic fibrosis phenotype. Hum Mutat. 2005;25:360-71 pubmed
	Bilan F, Thoreau V, Nacfer M, Derand R, Norez C, Cantereau A, et al. Syntaxin 8 impairs trafficking of cystic fibrosis transmembrane conductance regulator (CFTR) and inhibits its channel activity. J Cell Sci. 2004;117:1923-35 pubmed
	Willumsen N, Amstrup J, Møbjerg N, Jespersen A, Kristensen P, Larsen E. Mitochondria-rich cells as experimental model in studies of epithelial chloride channels. Biochim Biophys Acta. 2002;1566:28-43 pubmed
	Pan J, Bear C, Farragher S, Cutz E, Yeger H. Cystic fibrosis transmembrane conductance regulator modulates neurosecretory function in pulmonary neuroendocrine cell-related tumor cell line models. Am J Respir Cell Mol Biol. 2002;27:553-60 pubmed
	Bagorda A, Guerra L, Di Sole F, Hemle Kolb C, Cardone R, Fanelli T, et al. Reciprocal protein kinase A regulatory interactions between cystic fibrosis transmembrane conductance regulator and Na+/H+ exchanger isoform 3 in a renal polarized epithelial cell model. J Biol Chem. 2002;277:21480-8 pubmed

image

image 1 :

CFTR antibody in Human Placenta by Immunohistochemistry (IHC-P).

product information

brand :

R&D Systems

master code :

MAB25031

SKU :

MAB25031

product name :

CFTR C-Terminus Antibody

description :

The Human CFTR C-Terminus Antibody from R&D Systems is a mouse monoclonal antibody to CFTR. This antibody reacts with human. The Human CFTR C-Terminus Antibody has been validated for the following applications: Western Blot, Immunohistochemistry, Immunoprecipitation.

target :

CFTR

category :

Primary Antibodies

sizes available :

50 ug (also 25 ug)

buffer :

Lyophilized from a 0.2 µm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.

clonality :

Monoclonal

clone :

24-1

conjugate :

Unconjugated

host :

Mouse

immunogen :

Glutathione S-transferase-coupled CFTR, aa 1377-1480, Accession # P13569

isotype :

IgG2a

purity :

Protein A or G purified from hybridoma culture supernatant

species :

Human

specificity :

Detects in vitro synthesized CFTR and endogenous CFTR in Western blots.

gene symbol :

CFTR

accessionNumbers :

P13569

applications :

Western Blot, Immunohistochemistry, Immunoprecipitation

USD :

334

USD 2023 :

351 USD

alt names :

ABC35, ABCC7CF, ATP-binding cassette sub-family C member 7, ATP-binding cassette transporter sub-family C member 7, cAMP-dependent chloride channel, CFTR/MRP, Channel conductance-controlling ATPase, cystic fibrosis transmembrane conductance regulator, cystic fibrosis transmembrane conductance regulator (ATP-binding cassettesub-family C, member 7), cystic fibrosis transmembrane conductance regulator, ATP-binding cassette(sub-family C, member 7), dJ760C5.1, EC 3.6.3, MRP7EC 3.6.3.49, TNR-CFTR

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 6 months, -20 to -70 °C under sterile conditions after reconstitution.

more info or order :

R&D Systems product webpage