BRCA2 Antibody | R&D Systems MAB2476 product information

product summary

company name :

R&D Systems

product type :

antibody

product name :

BRCA2 Antibody

catalog :

MAB2476

quantity :

100 ug (also 25 ug)

price :

479 USD

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

234403

reactivity :

human

application :

western blot, immunohistochemistry

more info or order :

R&D Systems product webpage

citations: 8

Published Application/Species/Sample/Dilution	Reference
western blot; human; 1:1000; loading ...; fig 5b	Tseng W, Chen C, Chern C, Wang C, Lee W, Chi Y, et al. Targeting HR Repair as a Synthetic Lethal Approach to Increase DNA Damage Sensitivity by a RAD52 Inhibitor in BRCA2-Deficient Cancer Cells. Int J Mol Sci. 2021;22: pubmed publisher
	Ma Y, Chen P, Drisko J, Khabele D, Godwin A, Chen Q. Pharmacological ascorbate induces 'BRCAness' and enhances the effects of Poly(ADP-Ribose) polymerase inhibitors against BRCA1/2 wild-type ovarian cancer. Oncol Lett. 2020;19:2629-2638 pubmed publisher
	Im J, Lawrence J, Seelig D, NHO R. FoxM1-dependent RAD51 and BRCA2 signaling protects idiopathic pulmonary fibrosis fibroblasts from radiation-induced cell death. Cell Death Dis. 2018;9:584 pubmed publisher
	Maifrede S, Martin K, Podszywalow Bartnicka P, Sullivan Reed K, Langer S, Nejati R, et al. IGH/MYC Translocation Associates with BRCA2 Deficiency and Synthetic Lethality to PARP1 Inhibitors. Mol Cancer Res. 2017;15:967-972 pubmed publisher
	Nieborowska Skorska M, Sullivan K, Dasgupta Y, Podszywalow Bartnicka P, Hoser G, Maifrede S, et al. Gene expression and mutation-guided synthetic lethality eradicates proliferating and quiescent leukemia cells. J Clin Invest. 2017;127:2392-2406 pubmed publisher
	Ishiguro K, Zhu Y, Lin Z, Penketh P, Shyam K, Zhu R, et al. Cataloging antineoplastic agents according to their effectiveness against platinum-resistant and platinum-sensitive ovarian carcinoma cell lines. J Transl Sci. 2016;2:117-124 pubmed
	Yang G, Mercado Uribe I, Multani A, Sen S, Shih I, Wong K, et al. RAS promotes tumorigenesis through genomic instability induced by imbalanced expression of Aurora-A and BRCA2 in midbody during cytokinesis. Int J Cancer. 2013;133:275-85 pubmed publisher
	Yang G, Chang B, Yang F, Guo X, Cai K, Xiao X, et al. Aurora kinase A promotes ovarian tumorigenesis through dysregulation of the cell cycle and suppression of BRCA2. Clin Cancer Res. 2010;16:3171-81 pubmed publisher

image

image 1 :

Detection of Human BRCA2 antibody by Western Blot.

product information

brand :

R&D Systems, a Bio-Techne Brand

catalog number base :

MAB2476

SKU :

MAB2476

product name :

BRCA2 Antibody

Description :

The Human BRCA2 Antibody from R&D Systems is a mouse monoclonal antibody to BRCA2. This antibody reacts with human. The Human BRCA2 Antibody has been validated for the following applications: Western Blot, Immunohistochemistry.

target :

BRCA2

category :

Primary Antibodies

unit size :

100 ug (also 25 ug)

buffer :

Lyophilized from a 0.2 µm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.

clonality :

Monoclonal

clone :

234403

concentration :

LYOPH

conjugate :

Unconjugated

host :

Mouse

immunogen :

E. coli -derived recombinant human BRCA2, Met1-Thr200, Accession # P51587

isotype :

IgG1

purity :

Protein A or G purified from hybridoma culture supernatant

species :

Human

specificity :

Detects endogenous human BRCA2.

gene symbol :

BRCA2

accessionNumbers :

P51587

applications :

Western Blot, Immunohistochemistry

USD :

479 USD

alt names :

BRCA1/BRCA2-containing complex, subunit 2, BRCC2, breast and ovarian cancer susceptibility gene, early onset, breast cancer 2 tumor suppressor, breast cancer 2, early onset, breast cancer susceptibility protein BRCA2, breast cancer type 2 susceptibility protein, BROVCA2, FACD, FAD, FAD1, FANCB, FANCD, FANCD1Fanconi anemia, complementation group D1, Fanconi anemia group D1 protein, GLM3, PNCA2

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 6 months, -20 to -70 °C under sterile conditions after reconstitution.

more info or order :

R&D Systems product webpage