Human IL-15 Antibody | R&D Systems MAB2471-100 product information

product summary

company name :

R&D Systems

product type :

antibody

product name :

Human IL-15 Antibody

catalog :

MAB2471-100

quantity :

100 ug (also 25 ug, 500 ug)

price :

499 USD

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

34559

reactivity :

human, mouse

application :

western blot, neutralization, flow cytometry

more info or order :

R&D Systems product webpage

citations: 16

Reference
Shakiba Y, Vorobyev P, Yusubalieva G, Kochetkov D, Zajtseva K, Valikhov M, et al. Oncolytic therapy with recombinant vaccinia viruses targeting the interleukin-15 pathway elicits a synergistic response. Mol Ther Oncolytics. 2023;29:158-168 pubmed publisher
Rodr xed guez xc1 lvarez Y, Batista Roche L, Llópiz Arzuaga A, Puente P xe9 rez P, Mart xed nez Castillo R, Castro Velazco J, et al. Immunogenicity profile in African green monkeys of a vaccine candidate based on a mutated form of human Interleukin-15. BMC Immunol. 2021;22:79 pubmed publisher
Panigrahi S, Chen B, Fang M, Potashnikova D, Komissarov A, Lebedeva A, et al. CX3CL1 and IL-15 Promote CD8 T cell chemoattraction in HIV and in atherosclerosis. PLoS Pathog. 2020;16:e1008885 pubmed publisher
Oberoi P, Kamenjarin K, Ossa J, Uherek B, Bonig H, Wels W. Directed Differentiation of Mobilized Hematopoietic Stem and Progenitor Cells into Functional NK cells with Enhanced Antitumor Activity. Cells. 2020;9: pubmed publisher
Vidard L, Dureuil C, Baudhuin J, Vescovi L, Durand L, Sierra V, et al. CD137 (4-1BB) Engagement Fine-Tunes Synergistic IL-15- and IL-21-Driven NK Cell Proliferation. J Immunol. 2019;: pubmed publisher
Touil H, Kobert A, Lebeurrier N, Rieger A, Saikali P, Lambert C, et al. Human central nervous system astrocytes support survival and activation of B cells: implications for MS pathogenesis. J Neuroinflammation. 2018;15:114 pubmed publisher
Du Y, Tu G, Yang G, Li G, Yang D, Lang L, et al. MiR-205/YAP1 in Activated Fibroblasts of Breast Tumor Promotes VEGF-independent Angiogenesis through STAT3 Signaling. Theranostics. 2017;7:3972-3988 pubmed publisher
Van den Bergh J, Smits E, Versteven M, De Reu H, Berneman Z, Van Tendeloo V, et al. Characterization of Interleukin-15-Transpresenting Dendritic Cells for Clinical Use. J Immunol Res. 2017;2017:1975902 pubmed publisher
Ciccocioppo R, Gallia A, Avanzini M, Betti E, Picone C, Vanoli A, et al. A Refractory Celiac Patient Successfully Treated With Mesenchymal Stem Cell Infusions. Mayo Clin Proc. 2016;91:812-9 pubmed publisher
Anguille S, Van Acker H, Van den Bergh J, Willemen Y, Goossens H, Van Tendeloo V, et al. Interleukin-15 Dendritic Cells Harness NK Cell Cytotoxic Effector Function in a Contact- and IL-15-Dependent Manner. PLoS ONE. 2015;10:e0123340 pubmed publisher
Tsai C, Liong K, Gunalan M, Li N, Lim D, Fisher D, et al. Type I IFNs and IL-18 regulate the antiviral response of primary human Î³Î´ T cells against dendritic cells infected with Dengue virus. J Immunol. 2015;194:3890-900 pubmed publisher
Marra P, Mathew S, Grigoriadis A, Wu Y, Kyle Cezar F, Watkins J, et al. IL15RA drives antagonistic mechanisms of cancer development and immune control in lymphocyte-enriched triple-negative breast cancers. Cancer Res. 2014;74:4908-21 pubmed publisher
Machado Diaz A, Chico Capote A, Arrieta Aguero C, Rodríguez Alvarez Y, García Del Barco Herrera D, Estévez Del Toro M, et al. Proinflammatory soluble interleukin-15 receptor alpha is increased in rheumatoid arthritis. Arthritis. 2012;2012:943156 pubmed publisher
Muntasell A, Magri G, Pende D, Angulo A, Lopez Botet M. Inhibition of NKG2D expression in NK cells by cytokines secreted in response to human cytomegalovirus infection. Blood. 2010;115:5170-9 pubmed publisher
Tsukamoto K, Huang Y, Dorsey W, Carns B, Sharma V. Juxtacrine function of interleukin-15/interleukin-15 receptor system in tumour derived human B-cell lines. Clin Exp Immunol. 2006;146:559-66 pubmed
Ong P, Hamid Q, Travers J, Strickland I, Al Kerithy M, Boguniewicz M, et al. Decreased IL-15 may contribute to elevated IgE and acute inflammation in atopic dermatitis. J Immunol. 2002;168:505-10 pubmed

product information

master code :

MAB2471

SKU :

MAB2471-100

product name :

Human IL-15 Antibody

unit size :

100 ug (also 25 ug, 500 ug)

description :

The Human IL-15 Antibody from R&D Systems is a mouse monoclonal antibody to IL-15. This antibody reacts with human,mouse. The Human IL-15 Antibody has been validated for the following applications: Western Blot,Intracellular Staining by Flow Cytometry,Blocking,Flow Cytometry,Neutralization,Cell Culture,CyTOF-ready.

target :

IL-15

category :

Primary Antibodies

buffer :

Lyophilized from a 0.2 ╡m filtered solution in PBS with Trehalose. See Certificate of Analysis for details. *Small pack size (-SP) is supplied either lyophilized or as a 0.2 ╡m filtered solution in PBS.

clonality :

Monoclonal

clone :

34559

conjugate :

Unconjugated

host :

Mouse

immunogen :

E. coli -derived recombinant human IL-15, Asn49-Ser162, Accession # P40933

isotype :

IgG1

purity :

Protein A or G purified from ascites

species :

Human,Mouse

specificity :

Detects human IL-15 in direct ELISAs and Western blots. In direct ELISAs, no cross-reactivity with recombinant human (rh) IL-2, recombinant mouse IL-15, or rhIL-21 is observed.

gene symbol :

IL15

endotoxin note :

<0.10 EU per 1 ╡g of the antibody by the LAL method.

top caption :

Cell Proliferation Induced by IL-15 and Neutralization by Human IL-15 Antibody.

accessionNumbers :

P40933

applications :

Intracellular Staining by Flow Cytometry,Blocking,Flow Cytometry,Western Blot,Neutralization,Cell Culture,CyTOF-ready

USD :

499 USD

alt names :

IL15, IL-15MGC9721, interleukin 15, interleukin-15

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 6 months, -20 to -70 ░C under sterile conditions after reconstitution.

more info or order :

R&D Systems product webpage