Human IL-15 Antibody | R&D Systems MAB247 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

R&D Systems

product type :

antibody

product name :

Human IL-15 Antibody

catalog :

MAB247

quantity :

100 ug (also 25 ug, 500 ug)

price :

369 USD

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

34593

reactivity :

human

application :

western blot, neutralization, blocking or activating experiments

citations: 13

Published Application/Species/Sample/Dilution	Reference
blocking or activating experiments; human; fig 3a	Nata T, Basheer A, Cocchi F, van Besien R, Massoud R, Jacobson S, et al. Targeting the binding interface on a shared receptor subunit of a cytokine family enables the inhibition of multiple member cytokines with selectable target spectrum. J Biol Chem. 2015;290:22338-51 pubmed publisher
	Xie C, Jiang B, Qin L, Tellides G, Kirkiles Smith N, Jane Wit D, et al. Complement-activated interferon-γ-primed human endothelium transpresents interleukin-15 to CD8+ T cells. J Clin Invest. 2020;130:3437-3452 pubmed publisher
	Swadling L, Pallett L, Diniz M, Baker J, Amin O, Stegmann K, et al. Human Liver Memory CD8+ T Cells Use Autophagy for Tissue Residence. Cell Rep. 2020;30:687-698.e6 pubmed publisher
	Watson D, Yung B, Bergamaschi C, Chowdhury B, Bear J, Stellas D, et al. Scalable, cGMP-compatible purification of extracellular vesicles carrying bioactive human heterodimeric IL-15/lactadherin complexes. J Extracell Vesicles. 2018;7:1442088 pubmed publisher
	Benito Miguel M, García Carmona Y, Balsa A, Bautista Caro M, Arroyo Villa I, Cobo Ibáñez T, et al. IL-15 expression on RA synovial fibroblasts promotes B cell survival. PLoS ONE. 2012;7:e40620 pubmed publisher
	Sato N, Sabzevari H, Fu S, Ju W, Petrus M, Bamford R, et al. Development of an IL-15-autocrine CD8 T-cell leukemia in IL-15-transgenic mice requires the cis expression of IL-15R?. Blood. 2011;117:4032-40 pubmed publisher
	Perrot I, Deauvieau F, Massacrier C, Hughes N, Garrone P, Durand I, et al. TLR3 and Rig-like receptor on myeloid dendritic cells and Rig-like receptor on human NK cells are both mandatory for production of IFN-gamma in response to double-stranded RNA. J Immunol. 2010;185:2080-8 pubmed publisher
	Filer A, Parsonage G, Smith E, Osborne C, Thomas A, Curnow S, et al. Differential survival of leukocyte subsets mediated by synovial, bone marrow, and skin fibroblasts: site-specific versus activation-dependent survival of T cells and neutrophils. Arthritis Rheum. 2006;54:2096-108 pubmed
	Dean G, Barger A, Lavoy A. Cloning and expression of feline interleukin 15. Cytokine. 2005;29:77-83 pubmed
	Ferlazzo G, Pack M, Thomas D, Paludan C, Schmid D, Strowig T, et al. Distinct roles of IL-12 and IL-15 in human natural killer cell activation by dendritic cells from secondary lymphoid organs. Proc Natl Acad Sci U S A. 2004;101:16606-11 pubmed
	Miranda Carús M, Balsa A, Benito Miguel M, Pérez de Ayala C, Martin Mola E. IL-15 and the initiation of cell contact-dependent synovial fibroblast-T lymphocyte cross-talk in rheumatoid arthritis: effect of methotrexate. J Immunol. 2004;173:1463-76 pubmed
	Briard D, Brouty Boye D, Azzarone B, Jasmin C. Fibroblasts from human spleen regulate NK cell differentiation from blood CD34(+) progenitors via cell surface IL-15. J Immunol. 2002;168:4326-32 pubmed
	Corinti S, Albanesi C, la Sala A, Pastore S, Girolomoni G. Regulatory activity of autocrine IL-10 on dendritic cell functions. J Immunol. 2001;166:4312-8 pubmed

product information

brand :

R&D Systems

master code :

MAB247

SKU :

MAB247-100

product name :

Human IL-15 Antibody

description :

The Human IL-15 Antibody from R&D Systems is a mouse monoclonal antibody to IL-15. This antibody reacts with human. The Human IL-15 Antibody has been validated for the following applications: Western Blot, Neutralization.

target :

IL-15

category :

Primary Antibodies

unit size :

100 ug (also 25 ug, 500 ug)

buffer :

Lyophilized from a 0.2 µm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied as a 0.2 µm filtered solution in PBS.

clonality :

Monoclonal

clone :

34593

conjugate :

Unconjugated

host :

Mouse

immunogen :

E. coli -derived recombinant human IL-15, Asn49-Ser162, Accession # P40933

isotype :

IgG1

purity :

Protein A or G purified from ascites

species :

Human

specificity :

Detects human IL-15 in Western blots. In Western blots, no cross-reactivity with recombinant human IL-2 is observed.

gene symbol :

IL15

endotoxin note :

<0.10 EU per 1 µg of the antibody by the LAL method.

catalog number base :

MAB247

accessionNumbers :

P40933

applications :

Western Blot, Neutralization

2020 USD :

339

2021 USD :

369 USD

alt names :

IL15, IL-15MGC9721, interleukin 15, interleukin-15

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 6 months, -20 to -70 °C under sterile conditions after reconstitution.