product summary
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company name :
R&D Systems
product type :
antibody
product name :
LAP (TGF-beta 1) Antibody
catalog :
MAB2463
quantity :
500 ug (also 25 ug)
price :
429 USD
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
27232
reactivity :
human, mouse
application :
flow cytometry
more info or order :
R&D Systems product webpage
citations: 9
Published Application/Species/Sample/DilutionReference
  • flow cytometry; human
Hatano R, Ohnuma K, Otsuka H, Komiya E, Taki I, Iwata S, et al. CD26-mediated induction of EGR2 and IL-10 as potential regulatory mechanism for CD26 costimulatory pathway. J Immunol. 2015;194:960-72 pubmed publisher
  • flow cytometry; human; loading ...; fig 1b
Noyan F, Lee Y, Zimmermann K, Hardtke Wolenski M, Taubert R, Warnecke G, et al. Isolation of human antigen-specific regulatory T cells with high suppressive function. Eur J Immunol. 2014;44:2592-602 pubmed publisher
  • flow cytometry; human
Boswell S, Sharif S, Alisa A, Pereira S, Williams R, Behboudi S. Induction of latency-associated peptide (transforming growth factor-?(1)) expression on CD4+ T cells reduces Toll-like receptor 4 ligand-induced tumour necrosis factor-? production in a transforming growth factor-?-dependent manner. Immunology. 2011;133:278-87 pubmed publisher
  • flow cytometry; human
Oida T, Weiner H. Overexpression of TGF-ß 1 gene induces cell surface localized glucose-regulated protein 78-associated latency-associated peptide/TGF-ß. J Immunol. 2010;185:3529-35 pubmed publisher
  • flow cytometry; human
Savage N, De Boer T, Walburg K, Joosten S, van Meijgaarden K, Geluk A, et al. Human anti-inflammatory macrophages induce Foxp3+ GITR+ CD25+ regulatory T cells, which suppress via membrane-bound TGFbeta-1. J Immunol. 2008;181:2220-6 pubmed
  • flow cytometry; mouse
Nakamura K, Kitani A, Fuss I, Pedersen A, Harada N, Nawata H, et al. TGF-beta 1 plays an important role in the mechanism of CD4+CD25+ regulatory T cell activity in both humans and mice. J Immunol. 2004;172:834-42 pubmed
Trojan K, Zhu L, Aly M, Weimer R, Bulut N, Morath C, et al. Association of peripheral NK cell counts with Helios+ IFN-?- Tregs in patients with good long-term renal allograft function. Clin Exp Immunol. 2017;188:467-479 pubmed publisher
Oida T, Weiner H. TGF-? induces surface LAP expression on murine CD4 T cells independent of Foxp3 induction. PLoS ONE. 2010;5:e15523 pubmed publisher
Schuster C, Vaculik C, Fiala C, Meindl S, Brandt O, Imhof M, et al. HLA-DR+ leukocytes acquire CD1 antigens in embryonic and fetal human skin and contain functional antigen-presenting cells. J Exp Med. 2009;206:169-81 pubmed publisher
product information
SKU :
MAB2463
product name :
LAP (TGF-beta 1) Antibody
unit size :
500 ug (also 25 ug)
Description :
The Human LAP (TGF-beta 1) Antibody from R D Systems is a mouse monoclonal antibody to LAP (TGF-beta 1). This antibody reacts with human. The Human LAP (TGF-beta 1) Antibody has been validated for the following applications: Flow Cytometry, CyTOF-ready.
target :
LAP (TGF-beta 1)
category :
Primary Antibodies
buffer :
Lyophilized from a 0.2 µm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied as a 0.2 µm filtered solution in PBS.
clonality :
Monoclonal
clone :
27232
conjugate :
Unconjugated
host :
Mouse
immunogen :
S. frugiperda / EM insect ovarian cell line Sf / EM 21-derived recombinant human LAP (TGF-beta 1), Leu30-Arg278 (Cys33Ser), Accession # P01137
isotype :
IgG1
purity :
Protein A or G purified from hybridoma culture supernatant
species :
Human
specificity :
Detects human LAP (TGF-beta 1) in direct ELISAs. In direct ELISAs, this antibody does not cross-react with recombinant human (rh) TGF-beta 1, rhTGF-beta 2, rhTGF-beta 1.2, rhTGF-beta 3, or rhTGF-alpha .
gene symbol :
TGFB1
catalog number base :
MAB2463
accessionNumbers :
P01137
applications :
Flow Cytometry, CyTOF-ready
2020 Proposedprice USD :
429 USD
alt names :
CED, DPD1, LAP, LAP (TGFbeta 1), TGFB, TGFB1, TGFbeta, transforming growth factor beta 1
storage :
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 6 months, -20 to -70 °C under sterile conditions after reconstitution.
more info or order :
R&D Systems product webpage
company information
R&D Systems
614 McKinley Place N.E.
Minneapolis, MN 55413
info@RnDSystems.com
https://www.rndsystems.com
800 343-7475
headquarters: USA
R&D Systems develops and manufactures high-quality proteins and serves as a world leader in immunoassays. R&D Systems also produces quality antibodies, antibody arrays, stem cell and cell culture products, and cell selection and detection products, serving the life science and diagnostics industry.