Human LAP (TGF┐▀1) Antibody | R&D Systems MAB246-100 product information

product summary

company name :

R&D Systems

product type :

antibody

product name :

Human LAP (TGF┐▀1) Antibody

catalog :

MAB246-100

quantity :

100 ug (also 25 ug, 500 ug)

price :

459 USD

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

27235

reactivity :

human, rat

application :

western blot, immunohistochemistry, immunocytochemistry, neutralization, flow cytometry

more info or order :

R&D Systems product webpage

citations: 13

Reference
Bhuyan S, Pal B, Pathak L, Saikia P, Mitra S, Gayan S, et al. Targeting hypoxia-induced tumor stemness by activating pathogen-induced stem cell niche defense. Front Immunol. 2022;13:933329 pubmed publisher
Gorchs L, Oosthoek M, Yucel Lindberg T, Moro C, Kaipe H. Chemokine Receptor Expression on T Cells Is Modulated by CAFs and Chemokines Affect the Spatial Distribution of T Cells in Pancreatic Tumors. Cancers (Basel). 2022;14: pubmed publisher
Zhen G, Guo Q, Li Y, Wu C, Zhu S, Wang R, et al. Mechanical stress determines the configuration of TGFβ activation in articular cartilage. Nat Commun. 2021;12:1706 pubmed publisher
Gorchs L, Ahmed S, Mayer C, Knauf A, Fernández Moro C, Svensson M, et al. The vitamin D analogue calcipotriol promotes an anti-tumorigenic phenotype of human pancreatic CAFs but reduces T cell mediated immunity. Sci Rep. 2020;10:17444 pubmed publisher
Arakelyan A, Petersen J, Blazkova J, Margolis L. Macrophage-derived HIV-1 carries bioactive TGF-beta. Sci Rep. 2019;9:19100 pubmed publisher
Gorchs L, Fern xe1 ndez Moro C, Bankhead P, Kern K, Sadeak I, Meng Q, et al. Human Pancreatic Carcinoma-Associated Fibroblasts Promote Expression of Co-inhibitory Markers on CD4+ and CD8+ T-Cells. Front Immunol. 2019;10:847 pubmed publisher
Sun H, Xu J, Huang Q, Huang M, Li K, Qu K, et al. Reduced CD160 Expression Contributes to Impaired NK-cell Function and Poor Clinical Outcomes in Patients with HCC. Cancer Res. 2018;78:6581-6593 pubmed publisher
Boakye Y, Agyare C, Ayande G, Titiloye N, Asiamah E, Danquah K. Assessment of Wound-Healing Properties of Medicinal Plants: The Case of Phyllanthus muellerianus. Front Pharmacol. 2018;9:945 pubmed publisher
Maehara T, Mattoo H, Ohta M, Mahajan V, Moriyama M, Yamauchi M, et al. Lesional CD4+ IFN-?+ cytotoxic T lymphocytes in IgG4-related dacryoadenitis and sialoadenitis. Ann Rheum Dis. 2017;76:377-385 pubmed publisher
Hara M, Kirita A, Kondo W, Matsuura T, Nagatsuma K, Dohmae N, et al. LAP degradation product reflects plasma kallikrein-dependent TGF-β activation in patients with hepatic fibrosis. Springerplus. 2014;3:221 pubmed publisher
Boswell S, Sharif S, Alisa A, Pereira S, Williams R, Behboudi S. Induction of latency-associated peptide (transforming growth factor-?(1)) expression on CD4+ T cells reduces Toll-like receptor 4 ligand-induced tumour necrosis factor-? production in a transforming growth factor-?-dependent manner. Immunology. 2011;133:278-87 pubmed publisher
Birebent B, Lorho R, Lechartier H, de Guibert S, Alizadeh M, Vu N, et al. Suppressive properties of human CD4+CD25+ regulatory T cells are dependent on CTLA-4 expression. Eur J Immunol. 2004;34:3485-96 pubmed
Godfrey W, Spoden D, Ge Y, Baker S, Liu B, Levine B, et al. Cord blood CD4(+)CD25(+)-derived T regulatory cell lines express FoxP3 protein and manifest potent suppressor function. Blood. 2005;105:750-8 pubmed

product information

master code :

MAB246

SKU :

MAB246-100

product name :

Human LAP (TGF┐▀1) Antibody

unit size :

100 ug (also 25 ug, 500 ug)

description :

The Human LAP (TGF¿ß1) Antibody from R&D Systems is a mouse monoclonal antibody to LAP (TGF-beta 1). This antibody reacts with complex species category,human,rat,virus - hiv-1. The Human LAP (TGF¿ß1) Antibody has been validated for the following applications: Neutralization,Multiplex Assay,Flow Cytometry,Western Blot,Immunohistochemistry,Immunocytochemistry.

target :

LAP (TGF-beta 1)

category :

Primary Antibodies

buffer :

Lyophilized from a 0.2 ╡m filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 ╡m filtered solution in PBS.

clonality :

Monoclonal

clone :

27235

conjugate :

Unconjugated

host :

Mouse

immunogen :

S. frugiperda insect ovarian cell line Sf 21-derived recombinant human LAP (TGF┐▀1)

isotype :

IgG1

purity :

Protein A or G purified from ascites

species :

Complex Species Category,Human,Rat,Virus - HIV-1

specificity :

Detects human LAP in direct ELISAs and Western blots.

gene symbol :

TGFB1

endotoxin note :

<0.10 EU per 1 ╡g of the antibody by the LAL method.

top caption :

LAP (TGF-ss1) antibody in HEK293 Human Cell Line by Immunocytochemistry (ICC).

applications :

Multiplex Assay,Flow Cytometry,Western Blot,Neutralization,Immunohistochemistry,Immunocytochemistry

USD :

459 USD

alt names :

CED, DPD1, LAP, LAP (TGFbeta 1), TGFB, TGFB1, TGFbeta, transforming growth factor beta 1

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 6 months, -20 to -70 ░C under sterile conditions after reconstitution.

more info or order :

R&D Systems product webpage