Human Progranulin/PGRN Antibody | R&D Systems MAB2420 product information

product summary

company name :

R&D Systems

product type :

antibody

product name :

Human Progranulin/PGRN Antibody

catalog :

MAB2420

quantity :

100 ug (also 25 ug)

price :

499 USD

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

296628

reactivity :

human, mouse

application :

western blot, ELISA, immunocytochemistry, immunoprecipitation

more info or order :

R&D Systems product webpage

citations: 8

Published Application/Species/Sample/Dilution	Reference
ELISA; human; loading ...; fig 3c	Reifschneider A, Robinson S, van Lengerich B, Gnörich J, Logan T, Heindl S, et al. Loss of TREM2 rescues hyperactivation of microglia, but not lysosomal deficits and neurotoxicity in models of progranulin deficiency. EMBO J. 2022;41:e109108 pubmed publisher
	Monteys A, Hundley A, Ranum P, Tecedor L, Muehlmatt A, Lim E, et al. Regulated control of gene therapies by drug-induced splicing. Nature. 2021;596:291-295 pubmed publisher
	Götzl J, Brendel M, Werner G, Parhizkar S, Sebastian Monasor L, Kleinberger G, et al. Opposite microglial activation stages upon loss of PGRN or TREM2 result in reduced cerebral glucose metabolism. EMBO Mol Med. 2019;: pubmed publisher
	Suarez Calvet M, Capell A, Araque Caballero M, Morenas Rodríguez E, Fellerer K, Franzmeier N, et al. CSF progranulin increases in the course of Alzheimer's disease and is associated with sTREM2, neurodegeneration and cognitive decline. EMBO Mol Med. 2018;10: pubmed publisher
	Holler C, Taylor G, Deng Q, Kukar T. Intracellular Proteolysis of Progranulin Generates Stable, Lysosomal Granulins that Are Haploinsufficient in Patients with Frontotemporal Dementia Caused by GRN Mutations. Eneuro. 2017;4: pubmed publisher
	Sleegers K, Brouwers N, Van Damme P, Engelborghs S, Gijselinck I, van der Zee J, et al. Serum biomarker for progranulin-associated frontotemporal lobar degeneration. Ann Neurol. 2009;65:603-9 pubmed publisher
	Van Damme P, Van Hoecke A, Lambrechts D, Vanacker P, Bogaert E, van Swieten J, et al. Progranulin functions as a neurotrophic factor to regulate neurite outgrowth and enhance neuronal survival. J Cell Biol. 2008;181:37-41 pubmed publisher
	Shankaran S, Capell A, Hruscha A, Fellerer K, Neumann M, Schmid B, et al. Missense mutations in the progranulin gene linked to frontotemporal lobar degeneration with ubiquitin-immunoreactive inclusions reduce progranulin production and secretion. J Biol Chem. 2008;283:1744-53 pubmed

product information

master code :

MAB2420

SKU :

MAB2420

product name :

Human Progranulin/PGRN Antibody

unit size :

100 ug (also 25 ug)

description :

The Human Progranulin/PGRN Antibody from R&D Systems is a mouse monoclonal antibody to Progranulin/PGRN. This antibody reacts with human,mouse. The Human Progranulin/PGRN Antibody has been validated for the following applications: ELISA Detection,ELISA Development,ELISA Development (Detection),FRET,Immunocytochemistry,Immunoprecipitation,Western Blot.

target :

Progranulin/PGRN

category :

Primary Antibodies

buffer :

Lyophilized from a 0.2 ╡m filtered solution in Tris and NaCl with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 ╡m filtered solution in PBS.

clonality :

Monoclonal

clone :

296628

concentration :

LYOPH

conjugate :

Unconjugated

host :

Mouse

immunogen :

Mouse myeloma cell line NS0-derived recombinant human Progranulin/PGRN, Thr18-Leu593, Accession # P28799

isotype :

IgG2a

purity :

Protein A or G purified from hybridoma culture supernatant

species :

Human,Mouse

specificity :

Detects recombinant human Progranulin/PGRN in direct ELISAs and Western blots. In direct ELISAs and Western blots, no cross-reactivity with recombinant mouse Progranulin/PGRN is observed.

gene symbol :

GRN

accessionNumbers :

P28799

applications :

ELISA Detection,ELISA Development,ELISA Development (Detection),FRET,Immunocytochemistry,Immunoprecipitation,Western Blot

USD :

499 USD

alt names :

Acrogranin, CLN11, GEP, GP88, granulin precursor, GRN, PCDGF, PEPI, PGRN, Proepithelin

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 6 months, -20 to -70 ░C under sterile conditions after reconstitution.

more info or order :

R&D Systems product webpage