Human/Mouse PDX-1/IPF1 Antibody | R&D Systems MAB2419 product information

product summary

company name :

R&D Systems

product type :

antibody

product name :

Human/Mouse PDX-1/IPF1 Antibody

catalog :

MAB2419

quantity :

100 ug (also 25 ug)

price :

489 USD

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

267712

reactivity :

human, mouse

application :

western blot, immunohistochemistry, immunocytochemistry, immunohistochemistry - paraffin section

more info or order :

R&D Systems product webpage

citations: 12

Reference
Simon T, Riemer P, Jarosch A, Detjen K, Di Domenico A, Bormann F, et al. DNA methylation reveals distinct cells of origin for pancreatic neuroendocrine carcinomas and pancreatic neuroendocrine tumors. Genome Med. 2022;14:24 pubmed publisher
Usher E, Sabri N, Rohac R, Boal A, Mittag T, Showalter S. Intrinsically disordered substrates dictate SPOP subnuclear localization and ubiquitination activity. J Biol Chem. 2021;296:100693 pubmed publisher
Di Domenico A, Pipinikas C, Maire R, Br xe4 utigam K, Simillion C, Dettmer M, et al. Epigenetic landscape of pancreatic neuroendocrine tumours reveals distinct cells of origin and means of tumour progression. Commun Biol. 2020;3:740 pubmed publisher
Bernard H, Teijeiro A, Chaves Pérez A, Perna C, Satish B, Novials A, et al. Coxsackievirus B Type 4 Infection in β Cells Downregulates the Chaperone Prefoldin URI to Induce a MODY4-like Diabetes via Pdx1 Silencing. Cell Rep Med. 2020;1:100125 pubmed publisher
Gruber R, Panayiotou R, Nye E, Spencer Dene B, Stamp G, Behrens A. YAP1 and TAZ Control Pancreatic Cancer Initiation in Mice by Direct Up-regulation of JAK-STAT3 Signaling. Gastroenterology. 2016;151:526-39 pubmed publisher
Balaji S, Zhou Y, Ganguly A, Opara E, Soker S. The combined effect of PDX1, epidermal growth factor and poly-L-ornithine on human amnion epithelial cells' differentiation. BMC Dev Biol. 2016;16:8 pubmed publisher
Saxena P, Heng B, Bai P, Folcher M, Zulewski H, Fussenegger M. A programmable synthetic lineage-control network that differentiates human IPSCs into glucose-sensitive insulin-secreting beta-like cells. Nat Commun. 2016;7:11247 pubmed publisher
Lenz A, Toren Haritan G, Efrat S. Redifferentiation of adult human Î² cells expanded in vitro by inhibition of the WNT pathway. PLoS ONE. 2014;9:e112914 pubmed publisher
Park J, Hong S, Klimstra D, Goggins M, Maitra A, Hruban R. Pdx1 expression in pancreatic precursor lesions and neoplasms. Appl Immunohistochem Mol Morphol. 2011;19:444-9 pubmed publisher
Evans Molina C, ROBBINS R, Kono T, Tersey S, Vestermark G, Nunemaker C, et al. Peroxisome proliferator-activated receptor gamma activation restores islet function in diabetic mice through reduction of endoplasmic reticulum stress and maintenance of euchromatin structure. Mol Cell Biol. 2009;29:2053-67 pubmed publisher
Cho Y, Lim J, Yoo D, Kim J, Chung S, Park S, et al. Betacellulin and nicotinamide sustain PDX1 expression and induce pancreatic beta-cell differentiation in human embryonic stem cells. Biochem Biophys Res Commun. 2008;366:129-34 pubmed
Li Y, Zhang R, Qiao H, Zhang H, Wang Y, Yuan H, et al. Generation of insulin-producing cells from PDX-1 gene-modified human mesenchymal stem cells. J Cell Physiol. 2007;211:36-44 pubmed

product information

master code :

MAB2419

SKU :

MAB2419

product name :

Human/Mouse PDX-1/IPF1 Antibody

unit size :

100 ug (also 25 ug)

description :

The Human/Mouse PDX-1/IPF1 Antibody from R&D Systems is a mouse monoclonal antibody to PDX-1/IPF1. This antibody reacts with human,mouse. The Human/Mouse PDX-1/IPF1 Antibody has been validated for the following applications: Immunohistochemistry,Western Blot,Immunohistochemistry-Paraffin,Immunocytochemistry,Intracellular Staining by Flow Cytometry.

target :

PDX-1/IPF1

category :

Primary Antibodies

buffer :

Lyophilized from a 0.2 ╡m filtered solution in PBS with Trehalose. See Certificate of Analysis for details. *Small pack size (-SP) is supplied either lyophilized or as a 0.2 ╡m filtered solution in PBS.

clonality :

Monoclonal

clone :

267712

concentration :

LYOPH

conjugate :

Unconjugated

host :

Mouse

immunogen :

E. coli -derived recombinant human PDX-1, Ala91-Arg283, Accession # P52945

isotype :

IgG2b

purity :

Protein A or G purified from hybridoma culture supernatant

species :

Human,Mouse

specificity :

Detects human and mouse PDX-1 in Western blots.

gene symbol :

PDX1

top caption :

Detection of Mouse PDX-1/IPF1 antibody by Western Blot.

accessionNumbers :

P52945

applications :

Immunohistochemistry,Western Blot,Immunohistochemistry-Paraffin,Immunocytochemistry,Intracellular Staining by Flow Cytometry

USD :

489 USD

alt names :

Glucose-sensitive factor, IDX1, IDX-1GSF, Insulin promoter factor 1, insulin promoter factor 1, homeodomain transcription factor, Insulin upstream factor 1, IPF1, IPF1pancreas/duodenum homeobox protein 1, Islet/duodenum homeobox-1, MODY4IUF1, pancreatic and duodenal homeobox 1, pancreatic-duodenal homeobox factor 1, PDX-1IPF-1, somatostatin transcription factor 1, Somatostatin-transactivating factor 1, STF-1IUF-1

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 6 months, -20 to -70 ░C under sterile conditions after reconstitution.

more info or order :

R&D Systems product webpage