This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
R&D Systems
product type :
antibody
product name :
Human IL-4R alpha Antibody
catalog :
MAB230
quantity :
100 ug (also 25 ug, 500 ug)
price :
369 USD
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
25463
reactivity :
human
application :
western blot, immunohistochemistry, immunocytochemistry, neutralization, flow cytometry
citations: 19
Published Application/Species/Sample/DilutionReference
  • immunohistochemistry; human; 1:100; fig 4b
Dolzani P, Assirelli E, Pulsatelli L, Meliconi R, Mariani E, Neri S. Ex vivo physiological compression of human osteoarthritis cartilage modulates cellular and matrix components. PLoS ONE. 2019;14:e0222947 pubmed publisher
Burton O, Tamayo J, Stranks A, Koleoglou K, Oettgen H. Allergen-specific IgG antibody signaling through FcγRIIb promotes food tolerance. J Allergy Clin Immunol. 2018;141:189-201.e3 pubmed publisher
Gaggianesi M, Turdo A, Chinnici A, Lipari E, Apuzzo T, Benfante A, et al. IL4 Primes the Dynamics of Breast Cancer Progression via DUSP4 Inhibition. Cancer Res. 2017;77:3268-3279 pubmed publisher
Reece P, Gauvreau G, Sehmi R, Denburg J. IL-4 and IL-13 differentially regulate TLR-induced eosinophil-basophil differentiation of cord blood CD34+ progenitor cells. PLoS ONE. 2014;9:e100734 pubmed publisher
Assirelli E, Pulsatelli L, Dolzani P, Platano D, Olivotto E, Filardo G, et al. Human osteoarthritic cartilage shows reduced in vivo expression of IL-4, a chondroprotective cytokine that differentially modulates IL-1?-stimulated production of chemokines and matrix-degrading enzymes in vitro. PLoS ONE. 2014;9:e96925 pubmed publisher
Sarangthem V, Cho E, Bae S, Singh T, Kim S, Kim S, et al. Construction and application of elastin like polypeptide containing IL-4 receptor targeting peptide. PLoS ONE. 2013;8:e81891 pubmed publisher
Biancheri P, Di Sabatino A, Ammoscato F, Facciotti F, Caprioli F, Curciarello R, et al. Absence of a role for interleukin-13 in inflammatory bowel disease. Eur J Immunol. 2014;44:370-85 pubmed publisher
Volonté A, Di Tomaso T, Spinelli M, Todaro M, Sanvito F, Albarello L, et al. Cancer-initiating cells from colorectal cancer patients escape from T cell-mediated immunosurveillance in vitro through membrane-bound IL-4. J Immunol. 2014;192:523-32 pubmed publisher
Boulaftali Y, Hess P, Getz T, Cholka A, Stolla M, Mackman N, et al. Platelet ITAM signaling is critical for vascular integrity in inflammation. J Clin Invest. 2013;123:908-16 pubmed publisher
Amano Y, Yamashita Y, Kojima K, Yoshino K, Tanaka N, Sugamura K, et al. Hrs recognizes a hydrophobic amino acid cluster in cytokine receptors during ubiquitin-independent endosomal sorting. J Biol Chem. 2011;286:15458-72 pubmed publisher
Thors L, Bergh A, Persson E, Hammarsten P, Stattin P, Egevad L, et al. Fatty acid amide hydrolase in prostate cancer: association with disease severity and outcome, CB1 receptor expression and regulation by IL-4. PLoS ONE. 2010;5:e12275 pubmed publisher
Hu A, Fatma S, Cao J, Grunstein J, Nino G, Grumbach Y, et al. Th2 cytokine-induced upregulation of 11beta-hydroxysteroid dehydrogenase-1 facilitates glucocorticoid suppression of proasthmatic airway smooth muscle function. Am J Physiol Lung Cell Mol Physiol. 2009;296:L790-803 pubmed publisher
Eyerich K, Pennino D, Scarponi C, Foerster S, Nasorri F, Behrendt H, et al. IL-17 in atopic eczema: linking allergen-specific adaptive and microbial-triggered innate immune response. J Allergy Clin Immunol. 2009;123:59-66.e4 pubmed publisher
Aoudjehane L, Pissaia A, Scatton O, Podevin P, Massault P, Chouzenoux S, et al. Interleukin-4 induces the activation and collagen production of cultured human intrahepatic fibroblasts via the STAT-6 pathway. Lab Invest. 2008;88:973-85 pubmed publisher
Aoudjehane L, Podevin P, Scatton O, Jaffray P, Dusanter Fourt I, Feldmann G, et al. Interleukin-4 induces human hepatocyte apoptosis through a Fas-independent pathway. FASEB J. 2007;21:1433-44 pubmed
Hurst S, McLoughlin R, Monslow J, Owens S, Morgan L, Fuller G, et al. Secretion of oncostatin M by infiltrating neutrophils: regulation of IL-6 and chemokine expression in human mesothelial cells. J Immunol. 2002;169:5244-51 pubmed
Hirst S, Hallsworth M, Peng Q, Lee T. Selective induction of eotaxin release by interleukin-13 or interleukin-4 in human airway smooth muscle cells is synergistic with interleukin-1beta and is mediated by the interleukin-4 receptor alpha-chain. Am J Respir Crit Care Med. 2002;165:1161-71 pubmed
Albanesi C, Scarponi C, Sebastiani S, Cavani A, Federici M, Sozzani S, et al. A cytokine-to-chemokine axis between T lymphocytes and keratinocytes can favor Th1 cell accumulation in chronic inflammatory skin diseases. J Leukoc Biol. 2001;70:617-23 pubmed
de Lavareille A, Roufosse F, Schandene L, Stordeur P, Cogan E, Goldman M. Clonal Th2 cells associated with chronic hypereosinophilia: TARC-induced CCR4 down-regulation in vivo. Eur J Immunol. 2001;31:1037-46 pubmed
product information
brand :
R&D Systems
master code :
MAB230
SKU :
MAB230-100
product name :
Human IL-4R alpha Antibody
description :
The Human IL-4R alpha Antibody from R&D Systems is a mouse monoclonal antibody to IL-4R alpha. This antibody reacts with human. The Human IL-4R alpha Antibody has been validated for the following applications: Western Blot, Flow Cytometry, Immunohistochemistry, Neutralization, Immunocytochemistry, CyTOF-ready.
target :
IL-4R alpha
category :
Primary Antibodies
unit size :
100 ug (also 25 ug, 500 ug)
buffer :
Lyophilized from a 0.2 µm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied as a 0.2 µm filtered solution in PBS.
clonality :
Monoclonal
clone :
25463
conjugate :
Unconjugated
host :
Mouse
immunogen :
S. frugiperda insect ovarian cell line Sf 21-derived recombinant human IL-4 R, Gly24-His232, Accession # P24394
isotype :
IgG2a
purity :
Protein A or G purified from ascites
species :
Human
specificity :
Detects human IL-4 R alpha in direct ELISAs and Western blots. In direct ELISAs, no cross-reactivity with recombinant human (rh) IL-9 R, recombinant mouse IL-4 R, rhIL-5 R alpha , rhIL-5 R beta , rhIL-13 R alpha 1, or rhIL-13 R alpha 2 is observed.
gene symbol :
IL4RA
details of functionality :
ActivityAssaywCitation not found None None None None None
endotoxin note :
<0.10 EU per 1 µg of the antibody by the LAL method.
catalog number base :
MAB230
accessionNumbers :
P24394
applications :
Western Blot, Flow Cytometry, Immunohistochemistry, Neutralization, Immunocytochemistry, CyTOF-ready
2020 USD :
339
2021 USD :
369 USD
alt names :
CD124, CD124 antigen, IL-4 R alpha, IL-4 receptor subunit alpha, IL4R, IL4R alpha, IL-4R subunit alpha, IL-4RA, IL4RACD124, IL-4R-alpha, interleukin 4 receptor, interleukin-4 receptor alpha chain, interleukin-4 receptor subunit alpha
storage :
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 6 months, -20 to -70 °C under sterile conditions after reconstitution.
company information
R&D Systems
614 McKinley Place N.E.
Minneapolis, MN 55413
info@RnDSystems.com
https://www.rndsystems.com
800 343-7475
headquarters: USA
R&D Systems develops and manufactures high-quality proteins and serves as a world leader in immunoassays. R&D Systems also produces quality antibodies, antibody arrays, stem cell and cell culture products, and cell selection and detection products, serving the life science and diagnostics industry.