Human IL-4R alpha Antibody | R&D Systems MAB230-100 product information

product summary

company name :

R&D Systems

product type :

antibody

product name :

Human IL-4R alpha Antibody

catalog :

MAB230-100

quantity :

100 ug (also 25 ug, 500 ug)

price :

479 USD

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

25463

reactivity :

human, mouse

application :

western blot, immunohistochemistry, immunocytochemistry, neutralization, flow cytometry, immunohistochemistry - paraffin section, immunohistochemistry - frozen section

more info or order :

R&D Systems product webpage

citations: 35

Reference
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He S, Gu X, Yang J, Xu F, Hu J, Wang W, et al. Sphingomyelin synthase 2 is a positive regulator of the CSF1R-STAT3 pathway in pancreatic cancer-associated macrophage. Front Pharmacol. 2022;13:902016 pubmed publisher
D Arcy Q, Gharaee Kermani M, Zhilin Roth A, Macoska J. The IL-4/IL-13 signaling axis promotes prostatic fibrosis. PLoS ONE. 2022;17:e0275064 pubmed publisher
Fang F, Cao W, Mu Y, Okuyama H, Li L, Qiu J, et al. IL-4 prevents adenosine-mediated immunoregulation by inhibiting CD39 expression. JCI Insight. 2022;7: pubmed publisher
Mairpady Shambat S, G xf3 mez Mejia A, Schweizer T, Huemer M, Chang C, Acevedo C, et al. Hyperinflammatory environment drives dysfunctional myeloid cell effector response to bacterial challenge in COVID-19. PLoS Pathog. 2022;18:e1010176 pubmed publisher
Cleary M, Bharathy N, Abraham J, Kim J, Rudzinski E, Michalek J, et al. Interleukin-4 Receptor Inhibition Targeting Metastasis Independent of Macrophages. Mol Cancer Ther. 2021;20:906-914 pubmed publisher
Ma R, Zhang H, Li X, Zhang C, Selli C, Tagliavini G, et al. Monocyte-derived macrophages promote breast cancer bone metastasis outgrowth. J Exp Med. 2020;217: pubmed publisher
Chen C, Smith A, Cheung L, Pham Q, Urban J, Dawson H. Potentiation of IL-4 Signaling by Retinoic Acid in Intestinal Epithelial Cells and Macrophages-Mechanisms and Targets. Front Immunol. 2020;11:605 pubmed publisher
Rajendran S, Graef M, Chu T, von Herrath M. IL-4R is expressed on alpha and beta cells of human pancreata. Clin Immunol. 2020;214:108394 pubmed publisher
Karhausen J, Choi H, Maddipati K, Mathew J, Ma Q, Boulaftali Y, et al. Platelets trigger perivascular mast cell degranulation to cause inflammatory responses and tissue injury. Sci Adv. 2020;6:eaay6314 pubmed publisher
Dolzani P, Assirelli E, Pulsatelli L, Meliconi R, Mariani E, Neri S. Ex vivo physiological compression of human osteoarthritis cartilage modulates cellular and matrix components. PLoS ONE. 2019;14:e0222947 pubmed publisher
Llaguno Munive M, Romero Piña M, Serrano Bello J, Medina L, Uribe Uribe N, Salazar A, et al. Mifepristone Overcomes Tumor Resistance to Temozolomide Associated with DNA Damage Repair and Apoptosis in an Orthotopic Model of Glioblastoma. Cancers (Basel). 2018;11: pubmed publisher
Liu H, Antony S, Roy K, Juhasz A, Wu Y, Lu J, et al. Interleukin-4 and interleukin-13 increase NADPH oxidase 1-related proliferation of human colon cancer cells. Oncotarget. 2017;8:38113-38135 pubmed publisher
Burton O, Tamayo J, Stranks A, Koleoglou K, Oettgen H. Allergen-specific IgG antibody signaling through FcγRIIb promotes food tolerance. J Allergy Clin Immunol. 2018;141:189-201.e3 pubmed publisher
Gaggianesi M, Turdo A, Chinnici A, Lipari E, Apuzzo T, Benfante A, et al. IL4 Primes the Dynamics of Breast Cancer Progression via DUSP4 Inhibition. Cancer Res. 2017;77:3268-3279 pubmed publisher
Reece P, Gauvreau G, Sehmi R, Denburg J. IL-4 and IL-13 differentially regulate TLR-induced eosinophil-basophil differentiation of cord blood CD34+ progenitor cells. PLoS ONE. 2014;9:e100734 pubmed publisher
Assirelli E, Pulsatelli L, Dolzani P, Platano D, Olivotto E, Filardo G, et al. Human osteoarthritic cartilage shows reduced in vivo expression of IL-4, a chondroprotective cytokine that differentially modulates IL-1?-stimulated production of chemokines and matrix-degrading enzymes in vitro. PLoS ONE. 2014;9:e96925 pubmed publisher
Sarangthem V, Cho E, Bae S, Singh T, Kim S, Kim S, et al. Construction and application of elastin like polypeptide containing IL-4 receptor targeting peptide. PLoS ONE. 2013;8:e81891 pubmed publisher
Biancheri P, Di Sabatino A, Ammoscato F, Facciotti F, Caprioli F, Curciarello R, et al. Absence of a role for interleukin-13 in inflammatory bowel disease. Eur J Immunol. 2014;44:370-85 pubmed publisher
Volonté A, Di Tomaso T, Spinelli M, Todaro M, Sanvito F, Albarello L, et al. Cancer-initiating cells from colorectal cancer patients escape from T cell-mediated immunosurveillance in vitro through membrane-bound IL-4. J Immunol. 2014;192:523-32 pubmed publisher
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product information

brand :

R&D Systems

master code :

MAB230

SKU :

MAB230-100

product name :

Human IL-4R alpha Antibody

unit size :

100 ug (also 25 ug, 500 ug)

seo description :

The Human IL-4R alpha Antibody from R&D Systems is a mouse monoclonal antibody to IL-4R alpha. This antibody reacts with human,mouse. The Human IL-4R alpha Antibody has been validated for the following applications: Bioassay,Blocking,Binding Assay,Flow Cytometry,Western Blot,Neutralization,Immunohistochemistry,Immunohistochemistry-Paraffin,Immunohistochemistry-Frozen,In vivo assay,Immunocytochemistry,CyTOF-ready.

target :

IL-4R alpha

category :

Primary Antibodies

buffer :

Lyophilized from a 0.2 ╡m filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 ╡m filtered solution in PBS.

clonality :

Monoclonal

clone :

25463

conjugate :

Unconjugated

dilution :

Western Blot 1 ug/mL, Flow Cytometry 0.25 ug/10^6 cells, Immunohistochemistry 8-25 ug/mL, Neutralization 3-6 ng/mL, Immunocytochemistry 5-15 ug/mL, CyTOF-ready

host :

Mouse

immunogen :

S. frugiperda insect ovarian cell line Sf 21-derived recombinant human IL-4 R, Gly24-His232, Accession # P24394

isotype :

IgG2a

purity :

Protein A or G purified from ascites

species :

Human,Mouse

specificity :

Detects human IL-4 R alpha in direct ELISAs and Western blots. In direct ELISAs, no cross-reactivity with recombinant human (rh) IL-9 R, recombinant mouse IL-4 R, rhIL-5 R alpha , rhIL-5 R▀, rhIL-13 R alpha 1, or rhIL-13 R alpha 2 is observed.

gene symbol :

IL4RA

endotoxin note :

<0.10 EU per 1 ╡g of the antibody by the LAL method.

top caption :

Detection of IL-4 Ra antibody in Daudi Human Cell Line antibody by Flow Cytometry.

accessionNumbers :

P24394

applications :

CyTOF-ready,Bioassay,Blocking,Binding Assay,Flow Cytometry,Immunohistochemistry,Western Blot,Immunohistochemistry-Paraffin,Immunohistochemistry-Frozen,In vivo assay,Neutralization,Immunocytochemistry

USD :

479 USD

alt names :

CD124, CD124 antigen, IL-4 R alpha, IL-4 receptor subunit alpha, IL4R, IL4R alpha, IL-4R subunit alpha, IL-4RA, IL4RACD124, IL-4R-alpha, interleukin 4 receptor, interleukin-4 receptor alpha chain, interleukin-4 receptor subunit alpha

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 6 months, -20 to -70 ░C under sterile conditions after reconstitution.

more info or order :

R&D Systems product webpage