Human gp130 Antibody | R&D Systems MAB228-100 product information

product summary

company name :

R&D Systems

product type :

antibody

product name :

Human gp130 Antibody

catalog :

MAB228-100

quantity :

100 ug (also 25 ug, 500 ug)

price :

469 USD

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

28126

reactivity :

human

application :

neutralization, flow cytometry

more info or order :

R&D Systems product webpage

citations: 10

Reference
Sk x142 adanowska K, Bloch Y, Strand J, White K, Hua J, Aldridge D, et al. Structural basis of activation and antagonism of receptor signaling mediated by interleukin-27. Cell Rep. 2022;41:111490 pubmed publisher
Cheng J, Myers T, Levinger C, Kumar P, Kumar J, Goshu B, et al. IL-27 induces IFN/STAT1-dependent genes and enhances function of TIGIT+ HIVGag-specific T cells. iScience. 2022;25:103588 pubmed publisher
Morgan E, Macdonald A. Autocrine STAT3 activation in HPV positive cervical cancer through a virus-driven Rac1-NFκB-IL-6 signalling axis. PLoS Pathog. 2019;15:e1007835 pubmed publisher
Wilkinson A, Gartlan K, Kelly G, Samson L, Olver S, Avery J, et al. Granulocytes Are Unresponsive to IL-6 Due to an Absence of gp130. J Immunol. 2018;200:3547-3555 pubmed publisher
He Y, Ma N, Xing C, Wang X, Xiao H, Zheng M, et al. Novel IL-6-secreting γδT cells increased in patients with atherosclerotic cerebral infarction. Mol Med Rep. 2015;11:1497-503 pubmed publisher
Kruspe S, Meyer C, Hahn U. Chlorin e6 Conjugated Interleukin-6 Receptor Aptamers Selectively Kill Target Cells Upon Irradiation. Mol Ther Nucleic Acids. 2014;3:e143 pubmed publisher
Meyer C, Eydeler K, Magbanua E, Zivkovic T, Piganeau N, Lorenzen I, et al. Interleukin-6 receptor specific RNA aptamers for cargo delivery into target cells. RNA Biol. 2012;9:67-80 pubmed publisher
Ambarus C, Krausz S, van Eijk M, Hamann J, Radstake T, Reedquist K, et al. Systematic validation of specific phenotypic markers for in vitro polarized human macrophages. J Immunol Methods. 2012;375:196-206 pubmed publisher
Ara T, Song L, Shimada H, Keshelava N, Russell H, Metelitsa L, et al. Interleukin-6 in the bone marrow microenvironment promotes the growth and survival of neuroblastoma cells. Cancer Res. 2009;69:329-37 pubmed publisher
Erices A, Conget P, Rojas C, Minguell J. Gp130 activation by soluble interleukin-6 receptor/interleukin-6 enhances osteoblastic differentiation of human bone marrow-derived mesenchymal stem cells. Exp Cell Res. 2002;280:24-32 pubmed

product information

brand :

R&D Systems

master code :

MAB228

SKU :

MAB228-100

product name :

Human gp130 Antibody

unit size :

100 ug (also 25 ug, 500 ug)

seo description :

The Human gp130 Antibody from R&D Systems is a mouse monoclonal antibody to gp130/CD130. This antibody reacts with human. The Human gp130 Antibody has been validated for the following applications: Flow Cytometry,Neutralization,CyTOF-ready.

target :

gp130

category :

Primary Antibodies

buffer :

Lyophilized from a 0.2 ╡m filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 ╡m filtered solution in PBS.

clonality :

Monoclonal

clone :

28126

conjugate :

Unconjugated

dilution :

Flow Cytometry 2.5 ug/10^6 cells, Neutralization 0.04-0.2 ug/mL, CyTOF-ready

host :

Mouse

immunogen :

S. frugiperda insect ovarian cell line Sf 21-derived recombinant human gp130 extracellular domain

isotype :

IgG1

purity :

Protein A or G purified from ascites

species :

Human

specificity :

Detects human gp130 in direct ELISAs. In direct ELISAs, no cross-reactivity with recombinant human (rh) IL-2 R, rhIL-4 R, or rhIL-6 R is observed.

gene symbol :

IL6ST

endotoxin note :

<0.10 EU per 1 ╡g of the antibody by the LAL method.

top caption :

Cell Proliferation Induced by Oncostatin M/OSM and Neutralization by Human gp130 Antibody.

applications :

CyTOF-ready,Flow Cytometry,Neutralization

USD :

469 USD

alt names :

CD130, CD130 antigen, CDw130, DKFZp564F053, gp130, gp130 of the rheumatoid arthritis antigenic peptide-bearing soluble form, IL-6 receptor subunit beta, IL-6R subunit beta, IL-6RB, IL-6R-beta, IL6ST, interleukin 6 signal transducer (gp130, oncostatin M receptor), interleukin receptor beta chain, interleukin-6 receptor subunit beta, Interleukin-6 signal transducer, Membrane glycoprotein 130, membrane glycoprotein gp130, Oncostatin-M receptor subunit alpha

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 6 months, -20 to -70 ░C under sterile conditions after reconstitution.

more info or order :

R&D Systems product webpage