Human IL-6R alpha Antibody | R&D Systems MAB227 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

R&D Systems

product type :

antibody

product name :

Human IL-6R alpha Antibody

catalog :

MAB227

quantity :

100 ug (also 25 ug, 500 ug)

price :

369 USD

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

17506

reactivity :

human

application :

western blot, ELISA, neutralization, flow cytometry, blocking or activating experiments

citations: 20

Published Application/Species/Sample/Dilution	Reference
blocking or activating experiments; human; 1 ug/ml; loading ...; fig 4f	Li R, Rezk A, Li H, Gommerman J, Prat A, Bar Or A. Antibody-Independent Function of Human B Cells Contributes to Antifungal T Cell Responses. J Immunol. 2017;198:3245-3254 pubmed publisher
	Barrow M, Martin M, Coffey A, Andrews P, Jones G, Reaves D, et al. A functional role for the cancer disparity-linked genes, CRYβB2 and CRYβB2P1, in the promotion of breast cancer. Breast Cancer Res. 2019;21:105 pubmed publisher
	Rolvering C, Zimmer A, Ginolhac A, Margue C, Kirchmeyer M, Servais F, et al. The PD-L1- and IL6-mediated dampening of the IL27/STAT1 anticancer responses are prevented by α-PD-L1 or α-IL6 antibodies. J Leukoc Biol. 2018;104:969-985 pubmed publisher
	Uchibori T, Matsuda K, Shimodaira T, Sugano M, Uehara T, Honda T. IL-6 trans-signaling is another pathway to upregulate Osteopontin. Cytokine. 2017;90:88-95 pubmed publisher
	Munir H, Luu N, Clarke L, Nash G, McGettrick H. Comparative Ability of Mesenchymal Stromal Cells from Different Tissues to Limit Neutrophil Recruitment to Inflamed Endothelium. PLoS ONE. 2016;11:e0155161 pubmed publisher
	Sommer A, Fabri M. Vitamin D regulates cytokine patterns secreted by dendritic cells to promote differentiation of IL-22-producing T cells. PLoS ONE. 2015;10:e0130395 pubmed publisher
	Resheq Y, Li K, Ward S, Wilhelm A, Garg A, Curbishley S, et al. Contact-dependent depletion of hydrogen peroxide by catalase is a novel mechanism of myeloid-derived suppressor cell induction operating in human hepatic stellate cells. J Immunol. 2015;194:2578-86 pubmed publisher
	Becker T, Boyd S, Mijatov B, Gowrishankar K, Snoyman S, Pupo G, et al. Mutant B-RAF-Mcl-1 survival signaling depends on the STAT3 transcription factor. Oncogene. 2014;33:1158-66 pubmed publisher
	Zielinski C, Mele F, Aschenbrenner D, Jarrossay D, Ronchi F, Gattorno M, et al. Pathogen-induced human TH17 cells produce IFN-? or IL-10 and are regulated by IL-1?. Nature. 2012;484:514-8 pubmed publisher
	Nieman K, Kenny H, Penicka C, Ladanyi A, Buell Gutbrod R, Zillhardt M, et al. Adipocytes promote ovarian cancer metastasis and provide energy for rapid tumor growth. Nat Med. 2011;17:1498-503 pubmed publisher
	Duhen T, Geiger R, Jarrossay D, Lanzavecchia A, Sallusto F. Production of interleukin 22 but not interleukin 17 by a subset of human skin-homing memory T cells. Nat Immunol. 2009;10:857-63 pubmed publisher
	Ara T, Song L, Shimada H, Keshelava N, Russell H, Metelitsa L, et al. Interleukin-6 in the bone marrow microenvironment promotes the growth and survival of neuroblastoma cells. Cancer Res. 2009;69:329-37 pubmed publisher
	Kolliputi N, Waxman A. IL-6 cytoprotection in hyperoxic acute lung injury occurs via suppressor of cytokine signaling-1-induced apoptosis signal-regulating kinase-1 degradation. Am J Respir Cell Mol Biol. 2009;40:314-24 pubmed publisher
	Acosta Rodriguez E, Napolitani G, Lanzavecchia A, Sallusto F. Interleukins 1beta and 6 but not transforming growth factor-beta are essential for the differentiation of interleukin 17-producing human T helper cells. Nat Immunol. 2007;8:942-9 pubmed
	Ammit A, Moir L, Oliver B, Hughes J, Alkhouri H, Ge Q, et al. Effect of IL-6 trans-signaling on the pro-remodeling phenotype of airway smooth muscle. Am J Physiol Lung Cell Mol Physiol. 2007;292:L199-206 pubmed
	Mozaffarian D, Rimm E, King I, Lawler R, McDonald G, Levy W. trans fatty acids and systemic inflammation in heart failure. Am J Clin Nutr. 2004;80:1521-5 pubmed
	Hurst S, McLoughlin R, Monslow J, Owens S, Morgan L, Fuller G, et al. Secretion of oncostatin M by infiltrating neutrophils: regulation of IL-6 and chemokine expression in human mesothelial cells. J Immunol. 2002;169:5244-51 pubmed
	Erices A, Conget P, Rojas C, Minguell J. Gp130 activation by soluble interleukin-6 receptor/interleukin-6 enhances osteoblastic differentiation of human bone marrow-derived mesenchymal stem cells. Exp Cell Res. 2002;280:24-32 pubmed
	Hurst S, Wilkinson T, McLoughlin R, Jones S, Horiuchi S, Yamamoto N, et al. Il-6 and its soluble receptor orchestrate a temporal switch in the pattern of leukocyte recruitment seen during acute inflammation. Immunity. 2001;14:705-14 pubmed
	Asou H, Said J, Yang R, Munker R, Park D, Kamada N, et al. Mechanisms of growth control of Kaposi's sarcoma-associated herpes virus-associated primary effusion lymphoma cells. Blood. 1998;91:2475-81 pubmed

product information

brand :

R&D Systems

master code :

MAB227

SKU :

MAB227-100

product name :

Human IL-6R alpha Antibody

description :

The Human IL-6R alpha Antibody from R&D Systems is a mouse monoclonal antibody to IL-6R alpha. This antibody reacts with human. The Human IL-6R alpha Antibody has been validated for the following applications: Western Blot, Flow Cytometry, Neutralization, CyTOF-ready, ELISA Capture (Matched Antibody Pair).

target :

IL-6R alpha

category :

Primary Antibodies

unit size :

100 ug (also 25 ug, 500 ug)

buffer :

Lyophilized from a 0.2 µm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied as a 0.2 µm filtered solution in PBS.

clonality :

Monoclonal

clone :

17506

conjugate :

Unconjugated

host :

Mouse

immunogen :

S. frugiperda insect ovarian cell line Sf 21-derived recombinant human IL-6R alpha, Leu20-Asp339, Accession # P08887

isotype :

IgG1

purity :

Protein A or G purified from hybridoma culture supernatant

species :

Human

specificity :

Detects human IL-6R alpha in ELISAs and Western blots. In ELISAs, no cross-reactivity or interference was observed with recombinant human (rh) IL-1 alpha , recombinant mouse (rm) IL-1 alpha , rhIL-1 beta , rmIL-1 beta , rhIL-1ra, rhIL-2, rhIL-3, rmIL-3, rhIL-4, rmIL-4, rhIL-5, rmIL-5, rhIL-6, rmIL-6, rhIL-7, rmIL-7, rhIL-8, rhIL-9, rmIL-9, rhIL-10, or rhIL-11.

gene symbol :

IL6R

details of functionality :

ActivityAssaywCitation not found None None None None

endotoxin note :

<0.10 EU per 1 µg of the antibody by the LAL method.

catalog number base :

MAB227

accessionNumbers :

P08887

applications :

Western Blot, Flow Cytometry, Neutralization, CyTOF-ready, ELISA Capture (Matched Antibody Pair)

2020 USD :

339

2021 USD :

369 USD

alt names :

CD126, gp80, IL-6 R alpha, IL6Q, IL6R, IL6R alpha, IL-6R-1, IL6RA, IL-6RA, IL6RQ, interleukin 6 receptor

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 6 months, -20 to -70 °C under sterile conditions after reconstitution.