Human IL-6R alpha Antibody | R&D Systems MAB227-100 product information

product summary

company name :

R&D Systems

product type :

antibody

product name :

Human IL-6R alpha Antibody

catalog :

MAB227-100

quantity :

100 ug (also 25 ug, 500 ug)

price :

499 USD

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

17506

reactivity :

human

application :

western blot, ELISA, neutralization, flow cytometry

more info or order :

R&D Systems product webpage

citations: 32

Reference
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Shankar S, Stolp J, Juvet S, Beckett J, Macklin P, Issa F, et al. Ex vivo-expanded human CD19+TIM-1+ regulatory B cells suppress immune responses in vivo and are dependent upon the TIM-1/STAT3 axis. Nat Commun. 2022;13:3121 pubmed publisher
Karavyraki M, Porter R. Evidence of a role for interleukin-6 in anoikis resistance in oral squamous cell carcinoma. Med Oncol. 2022;39:60 pubmed publisher
Sugahara S, Hanaoka K, Emori T, Takeshita N, Fujii Y, Nakano M, et al. Peficitinib improves bone fragility by recovering bone turnover imbalance in arthritic mice. J Pharmacol Sci. 2022;148:134-141 pubmed publisher
Pollmann K, Raj Murthi S, Kra x10d un D, Schwarzmayr T, Petry A, Cleuziou J, et al. Molecular signaling pathways in right ventricular impairment of adult patients after tetralogy of Fallot repair. Cardiovasc Diagn Ther. 2021;11:1295-1309 pubmed publisher
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Kutys M, Polacheck W, Welch M, Gagnon K, Koorman T, Kim S, et al. Uncovering mutation-specific morphogenic phenotypes and paracrine-mediated vessel dysfunction in a biomimetic vascularized mammary duct platform. Nat Commun. 2020;11:3377 pubmed publisher
Barrow M, Martin M, Coffey A, Andrews P, Jones G, Reaves D, et al. A functional role for the cancer disparity-linked genes, CRYβB2 and CRYβB2P1, in the promotion of breast cancer. Breast Cancer Res. 2019;21:105 pubmed publisher
Kristóf E, Klusóczki Á, Veress R, Shaw A, Combi Z, Varga K, et al. Interleukin-6 released from differentiating human beige adipocytes improves browning. Exp Cell Res. 2019;: pubmed publisher
Rolvering C, Zimmer A, Ginolhac A, Margue C, Kirchmeyer M, Servais F, et al. The PD-L1- and IL6-mediated dampening of the IL27/STAT1 anticancer responses are prevented by α-PD-L1 or α-IL6 antibodies. J Leukoc Biol. 2018;104:969-985 pubmed publisher
Uchibori T, Matsuda K, Shimodaira T, Sugano M, Uehara T, Honda T. IL-6 trans-signaling is another pathway to upregulate Osteopontin. Cytokine. 2017;90:88-95 pubmed publisher
Catar R, Witowski J, Zhu N, LÃ¼cht C, Derrac Soria A, Uceda Fernandez J, et al. IL-6 Trans-Signaling Links Inflammation with Angiogenesis in the Peritoneal Membrane. J Am Soc Nephrol. 2017;28:1188-1199 pubmed publisher
Munir H, Luu N, Clarke L, Nash G, McGettrick H. Comparative Ability of Mesenchymal Stromal Cells from Different Tissues to Limit Neutrophil Recruitment to Inflamed Endothelium. PLoS ONE. 2016;11:e0155161 pubmed publisher
Jokerst J, Chen Z, Xu L, Nolley R, Chang E, Mitchell B, et al. A Magnetic Bead-Based Sensor for the Quantification of Multiple Prostate Cancer Biomarkers. PLoS ONE. 2015;10:e0139484 pubmed publisher
Lissat A, Joerschke M, Shinde D, Braunschweig T, Meier A, Makowska A, et al. IL6 secreted by Ewing sarcoma tumor microenvironment confers anti-apoptotic and cell-disseminating paracrine responses in Ewing sarcoma cells. BMC Cancer. 2015;15:552 pubmed publisher
Sommer A, Fabri M. Vitamin D regulates cytokine patterns secreted by dendritic cells to promote differentiation of IL-22-producing T cells. PLoS ONE. 2015;10:e0130395 pubmed publisher
Majety M, Pradel L, Gies M, Ries C. Fibroblasts Influence Survival and Therapeutic Response in a 3D Co-Culture Model. PLoS ONE. 2015;10:e0127948 pubmed publisher
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Resheq Y, Li K, Ward S, Wilhelm A, Garg A, Curbishley S, et al. Contact-dependent depletion of hydrogen peroxide by catalase is a novel mechanism of myeloid-derived suppressor cell induction operating in human hepatic stellate cells. J Immunol. 2015;194:2578-86 pubmed publisher
Nowatari T, Murata S, Nakayama K, Sano N, Maruyama T, Nozaki R, et al. Sphingosine 1-phosphate has anti-apoptotic effect on liver sinusoidal endothelial cells and proliferative effect on hepatocytes in a paracrine manner in human. Hepatol Res. 2015;45:1136-45 pubmed publisher
Becker T, Boyd S, Mijatov B, Gowrishankar K, Snoyman S, Pupo G, et al. Mutant B-RAF-Mcl-1 survival signaling depends on the STAT3 transcription factor. Oncogene. 2014;33:1158-66 pubmed publisher
Zielinski C, Mele F, Aschenbrenner D, Jarrossay D, Ronchi F, Gattorno M, et al. Pathogen-induced human TH17 cells produce IFN-? or IL-10 and are regulated by IL-1?. Nature. 2012;484:514-8 pubmed publisher
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product information

brand :

R&D Systems

master code :

MAB227

SKU :

MAB227-100

product name :

Human IL-6R alpha Antibody

unit size :

100 ug (also 25 ug, 500 ug)

seo description :

The Human IL-6R alpha Antibody from R&D Systems is a mouse monoclonal antibody to IL-6R alpha. This antibody reacts with human. The Human IL-6R alpha Antibody has been validated for the following applications: ELISA Development,Flow Cytometry,Western Blot,Neutralization,In vivo assay,ELISA Capture (Matched Antibody Pair),CyTOF-ready.

target :

IL-6R alpha

category :

Primary Antibodies

buffer :

Lyophilized from a 0.2 ╡m filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 ╡m filtered solution in PBS.

clonality :

Monoclonal

clone :

17506

conjugate :

Unconjugated

dilution :

Western Blot 1 ug/mL, Flow Cytometry 0.25 ug/10^6 cells, Neutralization 0.04-0.2 ug/mL, CyTOF-ready, ELISA Capture (Matched Antibody Pair) 2-8 ug/mL

host :

Mouse

immunogen :

S. frugiperda insect ovarian cell line Sf 21-derived recombinant human IL-6R alpha, Leu20-Asp339, Accession # P08887

isotype :

IgG1

purity :

Protein A or G purified from hybridoma culture supernatant

species :

Human

specificity :

Detects human IL-6R alpha in ELISAs and Western blots. In ELISAs, no cross-reactivity or interference was observed with recombinant human (rh) IL-1 alpha , recombinant mouse (rm) IL-1 alpha , rhIL-1▀, rmIL-1▀, rhIL-1ra, rhIL-2, rhIL-3, rmIL-3, rhIL-4, rmIL-4, rhIL-5, rmIL-5, rhIL-6, rmIL-6, rhIL-7, rmIL-7, rhIL-8, rhIL-9, rmIL-9, rhIL-10, or rhIL-11.

gene symbol :

IL6R

endotoxin note :

<0.10 EU per 1 ╡g of the antibody by the LAL method.

top caption :

Detection of Recombinant Human IL-6R alpha antibody by Western Blot.

accessionNumbers :

P08887

applications :

ELISA Capture (Matched Antibody Pair),CyTOF-ready,ELISA Development,Flow Cytometry,Western Blot,In vivo assay,Neutralization

USD :

499 USD

alt names :

CD126, gp80, IL-6 R alpha, IL6Q, IL6R, IL6R alpha, IL-6R-1, IL6RA, IL-6RA, IL6RQ, interleukin 6 receptor

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 6 months, -20 to -70 ░C under sterile conditions after reconstitution.

more info or order :

R&D Systems product webpage