Human TNF RII/TNFRSF1B Antibody | R&D Systems MAB226-100 product information

product summary

company name :

R&D Systems

product type :

antibody

product name :

Human TNF RII/TNFRSF1B Antibody

catalog :

MAB226-100

quantity :

100 ug (also 25 ug, 500 ug)

price :

469 USD

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

22221

reactivity :

human

application :

western blot, immunohistochemistry, immunocytochemistry, neutralization, flow cytometry, immunohistochemistry - paraffin section

more info or order :

R&D Systems product webpage

citations: 17

Reference
Sander C, Rush E, Shi J, Arantes L, Tesi R, Ross M, et al. Co-expression of TNF receptors 1 and 2 on melanomas facilitates soluble TNF-induced resistance to MAPK pathway inhibitors. J Transl Med. 2022;20:331 pubmed publisher
Carri xf3 n B, Liu Y, Hadi M, Lundstrom J, Christensen J, Ammitzb xf8 ll C, et al. Transcriptome and Function of Novel Immunosuppressive Autoreactive Invariant Natural Killer T Cells That Are Absent in Progressive Multiple Sclerosis. Neurol Neuroimmunol Neuroinflamm. 2021;8: pubmed publisher
Bradley J, Wang J, Pacey S, Warren A, Pober J, Al Lamki R. Tumor necrosis factor receptor-2 signaling pathways promote survival of cancer stem-like CD133+ cells in clear cell renal carcinoma. FASEB Bioadv. 2020;2:126-144 pubmed publisher
Chung C, Kitzler T, Kachurina N, Pessina K, Babayeva S, Bitzan M, et al. Intrinsic tumor necrosis factor-α pathway is activated in a subset of patients with focal segmental glomerulosclerosis. PLoS ONE. 2019;14:e0216426 pubmed publisher
Monguió Tortajada M, Franquesa M, Sarrias M, Borras F. Low doses of LPS exacerbate the inflammatory response and trigger death on TLR3-primed human monocytes. Cell Death Dis. 2018;9:499 pubmed publisher
Wang X, He Z, Liu H, Yousefi S, Simon H. Neutrophil Necroptosis Is Triggered by Ligation of Adhesion Molecules following GM-CSF Priming. J Immunol. 2016;197:4090-4100 pubmed
Al Lamki R, Wang J, Yang J, Burrows N, Maxwell P, Eisen T, et al. Tumor necrosis factor receptor 2-signaling in CD133-expressing cells in renal clear cell carcinoma. Oncotarget. 2016;7:24111-24 pubmed publisher
Kachurina N, Chung C, Benderoff E, Babayeva S, Bitzan M, Goodyer P, et al. Novel unbiased assay for circulating podocyte-toxic factors associated with recurrent focal segmental glomerulosclerosis. Am J Physiol Renal Physiol. 2016;310:F1148-56 pubmed publisher
Sonoda Y, Gohda T, Suzuki Y, Omote K, Ishizaka M, Matsuoka J, et al. Circulating TNF receptors 1 and 2 are associated with the severity of renal interstitial fibrosis in IgA nephropathy. PLoS ONE. 2015;10:e0122212 pubmed publisher
Esser C, Bachmann A, Kuhn D, Schuldt K, FÃ¶rster B, Thiel M, et al. Evidence of promiscuous endothelial binding by Plasmodium falciparum-infected erythrocytes. Cell Microbiol. 2014;16:701-8 pubmed publisher
Nomura T, Aoyama M, Waguri Nagaya Y, Goto Y, Suzuki M, Miyazawa K, et al. Tumor necrosis factor stimulates osteoclastogenesis from human bone marrow cells under hypoxic conditions. Exp Cell Res. 2014;321:167-77 pubmed publisher
Espín R, Roca F, Candel S, Sepulcre M, González Rosa J, Alcaraz Pérez F, et al. TNF receptors regulate vascular homeostasis in zebrafish through a caspase-8, caspase-2 and P53 apoptotic program that bypasses caspase-3. Dis Model Mech. 2013;6:383-96 pubmed publisher
Ding B, Kirkiles Smith N, Pober J. FOXO3a regulates oxygen-responsive expression of tumor necrosis factor receptor 2 in human dermal microvascular endothelial cells. J Biol Chem. 2009;284:19331-9 pubmed publisher
van Mierlo G, Scherer H, Hameetman M, Morgan M, Flierman R, Huizinga T, et al. Cutting edge: TNFR-shedding by CD4+CD25+ regulatory T cells inhibits the induction of inflammatory mediators. J Immunol. 2008;180:2747-51 pubmed
Ebert E, Mehta V. Human intestinal intraepithelial lymphocytes keep TNF alpha levels low by cell uptake and feedback inhibition of transcription. Cell Immunol. 2006;241:7-13 pubmed
Hadjadj S, Cloutier I, Geoffroy P, Tanguay J. Stent implantation in coronary porcine arteries is associated with early activation of TNFalpha and TNFalpha receptor II expression. Atherosclerosis. 2007;192:25-32 pubmed
Chopin V, Slomianny C, Hondermarck H, Le Bourhis X. Synergistic induction of apoptosis in breast cancer cells by cotreatment with butyrate and TNF-alpha, TRAIL, or anti-Fas agonist antibody involves enhancement of death receptors' signaling and requires P21(waf1). Exp Cell Res. 2004;298:560-73 pubmed

product information

brand :

R&D Systems

master code :

MAB226

SKU :

MAB226-100

product name :

Human TNF RII/TNFRSF1B Antibody

unit size :

100 ug (also 25 ug, 500 ug)

seo description :

The Human TNF RII/TNFRSF1B Antibody from R&D Systems is a mouse monoclonal antibody to TNF RII/TNFRSF1B. This antibody reacts with human,porcine. The Human TNF RII/TNFRSF1B Antibody has been validated for the following applications: Flow Cytometry,Western Blot,Neutralization,Immunohistochemistry,Immunohistochemistry-Paraffin,Immunocytochemistry.

target :

TNF RII/TNFRSF1B

category :

Primary Antibodies

buffer :

Lyophilized from a 0.2 ╡m filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 ╡m filtered solution in PBS.

clonality :

Monoclonal

clone :

22221

conjugate :

Unconjugated

dilution :

Flow Cytometry 0.25 ug/10^6 cells, Neutralization 0.5-1.5 ug/mL, Immunocytochemistry 8-25 ug/mL

host :

Mouse

immunogen :

E. coli -derived recombinant human TNF RII, Leu23-Asp257, Accession # P20333

isotype :

IgG2a

purity :

Protein A or G purified from ascites

species :

Human,Porcine

specificity :

Detects human TNF RII/TNFRSF1B in direct ELISAs. In direct ELISAs, no cross-reactivity with recombinant human (rh) 4-1BB, rhCD27, rhCD30, rhCD40, rhDR3, rhDR6, rhFas, rhGITR, rhHVEM, rhLTR▀, rhNGF R, rhOPG, rhRANK, rhTNF RI, or recombinant mouse TNF RII is observed. Neutralizes the biological effect of rhTNF RII but not rhTNF RI.

gene symbol :

TNFRSF1B

endotoxin note :

<0.10 EU per 1 ╡g of the antibody by the LAL method.

top caption :

Detection of TNF RII/TNFRSF1B antibody in Human Granulocytes antibody by Flow Cytometry.

accessionNumbers :

P20333

applications :

Flow Cytometry,Immunohistochemistry,Western Blot,Immunohistochemistry-Paraffin,Neutralization,Immunocytochemistry

USD :

469 USD

alt names :

CD120b, CD120b antigen, Etanercept, p75 TNF receptor, p75TBPII, p75TNFR, soluble TNFR1B variant 1, TNFBRp80 TNF-alpha receptor, TNF-R2, TNFR2TNFR1B, TNF-R75, TNFR80, TNFRII, TNF-RII, TNF-R-II, TNFR-II, TNFRSF1B, tumor necrosis factor beta receptor, tumor necrosis factor binding protein 2, Tumor necrosis factor receptor 2, tumor necrosis factor receptor superfamily member 1B, tumor necrosis factor receptor superfamily, member 1B, Tumor necrosis factor receptor type II

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 6 months, -20 to -70 ░C under sterile conditions after reconstitution.

more info or order :

R&D Systems product webpage