Insect Cathepsin L Antibody | R&D Systems MAB22591 product information

product summary

company name :

R&D Systems

product type :

antibody

product name :

Insect Cathepsin L Antibody

catalog :

MAB22591

quantity :

100 ug (also 25 ug)

price :

449 USD

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

193702

reactivity :

human

application :

western blot, immunohistochemistry, immunoprecipitation

more info or order :

R&D Systems product webpage

citations: 15

Reference
Yu M, Ye H, De Paula R, Mangleburg C, Wu T, Lee T, et al. Functional screening of lysosomal storage disorder genes identifies modifiers of alpha-synuclein neurotoxicity. PLoS Genet. 2023;19:e1010760 pubmed publisher
O Brien C, Younger S, Jan L, Jan Y. The GARP complex prevents sterol accumulation at the trans-Golgi network during dendrite remodeling. J Cell Biol. 2023;222: pubmed publisher
Wang L, Lin G, Zuo Z, Li Y, Byeon S, Pandey A, et al. Neuronal activity induces glucosylceramide that is secreted via exosomes for lysosomal degradation in glia. Sci Adv. 2022;8:eabn3326 pubmed publisher
Tao X, Zhu Y, Diaz Perez Z, Yu S, Foley J, Stewart T, et al. Phenylbutyrate modulates polyamine acetylase and ameliorates Snyder-Robinson syndrome in a Drosophila model and patient cells. JCI Insight. 2022;7: pubmed publisher
Florian J, DeMatte S, Sweeder D, Ordway R, Kawasaki F. Genetic analysis of the Drosophila ESCRT-III complex protein, VPS24, reveals a novel function in lysosome homeostasis. PLoS ONE. 2021;16:e0251184 pubmed publisher
Götz T, Puchkov D, Lysiuk V, Lützkendorf J, Nikonenko A, Quentin C, et al. Rab2 regulates presynaptic precursor vesicle biogenesis at the trans-Golgi. J Cell Biol. 2021;220: pubmed publisher
Mangleburg C, Wu T, Yalamanchili H, Guo C, Hsieh Y, Duong D, et al. Integrated analysis of the aging brain transcriptome and proteome in tauopathy. Mol Neurodegener. 2020;15:56 pubmed publisher
Ye H, Ojelade S, Li Kroeger D, Zuo Z, Wang L, Li Y, et al. Retromer subunit, VPS29, regulates synaptic transmission and is required for endolysosomal function in the aging brain. elife. 2020;9: pubmed publisher
Mondragon A, Yalonetskaya A, Ortega A, Zhang Y, Naranjo O, Elguero J, et al. Lysosomal Machinery Drives Extracellular Acidification to Direct Non-apoptotic Cell Death. Cell Rep. 2019;27:11-19.e3 pubmed publisher
Senturk M, Lin G, Zuo Z, Mao D, Watson E, Mikos A, et al. Ubiquilins regulate autophagic flux through mTOR signalling and lysosomal acidification. Nat Cell Biol. 2019;21:384-396 pubmed publisher
Mao D, Lin G, Tepe B, Zuo Z, Tan K, Senturk M, et al. VAMP associated proteins are required for autophagic and lysosomal degradation by promoting a PtdIns4P-mediated endosomal pathway. Autophagy. 2019;15:1214-1233 pubmed publisher
Li C, Brazill J, Liu S, Bello C, Zhu Y, Morimoto M, et al. Spermine synthase deficiency causes lysosomal dysfunction and oxidative stress in models of Snyder-Robinson syndrome. Nat Commun. 2017;8:1257 pubmed publisher
Hasanagic M, van Meel E, Luan S, Aurora R, Kornfeld S, Eissenberg J. The lysosomal enzyme receptor protein (LERP) is not essential, but is implicated in lysosomal function in Drosophila melanogaster. Biol Open. 2015;4:1316-25 pubmed publisher
Luan S, Ilvarsonn A, Eissenberg J. The unique GGA clathrin adaptor of Drosophila melanogaster is not essential. PLoS ONE. 2012;7:e45163 pubmed publisher
Johnson G, Jiang W. Characterization of cathepsin L secreted by Sf21 insect cells. Arch Biochem Biophys. 2005;444:7-14 pubmed

product information

master code :

MAB22591

SKU :

MAB22591

product name :

Insect Cathepsin L Antibody

unit size :

100 ug (also 25 ug)

description :

The Insect Cathepsin L Antibody from R&D Systems is a mouse monoclonal antibody to Cathepsin L. This antibody reacts with drosophila melanogaster,human,insect,insect - drosophila,insect - drosophila melanogaster. The Insect Cathepsin L Antibody has been validated for the following applications: Western Blot,Immunohistochemistry,Immunoprecipitation.

target :

Cathepsin L

category :

Primary Antibodies

buffer :

Lyophilized from a 0.2 ╡m filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 ╡m filtered solution in PBS.

clonality :

Monoclonal

clone :

193702

concentration :

LYOPH

conjugate :

Unconjugated

host :

Mouse

immunogen :

S. frugiperda ovarian cell line Sf 21-derived Insect Cathepsin L

isotype :

IgG1

purity :

Protein A or G purified from hybridoma culture supernatant

species :

Drosophila melanogaster,Human,Insect,Insect - Drosophila,Insect - Drosophila melanogaster

specificity :

Detects pro and mature forms of Insect Cathepsin L in direct ELISAs and Western blots. In Western blots, less than 5% cross-reactivity with recombinant human Cathepsin L is observed and no cross-reactivity with recombinant mouse Cathepsin L is observed.

gene symbol :

CTSL1

applications :

Immunohistochemistry,Immunoprecipitation,Western Blot

USD :

449 USD

alt names :

cathepsin L, cathepsin L1, CATL, CTSL, CTSL1, CTSLEC 3.4.22.15, EC 3.4.22, FLJ31037, Major excreted protein, MEP

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 6 months, -20 to -70 ░C under sterile conditions after reconstitution.

more info or order :

R&D Systems product webpage