Human TNF RI/TNFRSF1A Antibody | R&D Systems MAB225 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

R&D Systems

product type :

antibody

product name :

Human TNF RI/TNFRSF1A Antibody

catalog :

MAB225

quantity :

100 ug (also 25 ug, 500 ug)

price :

369 USD

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

16803

reactivity :

human

application :

western blot, neutralization, flow cytometry, blocking or activating experiments

citations: 23

Published Application/Species/Sample/Dilution	Reference
blocking or activating experiments; human; 10 ug/ml; loading ...; fig 4e	Zhou Q, Wu X, Wang X, Yu Z, Pan T, Li Z, et al. The reciprocal interaction between tumor cells and activated fibroblasts mediated by TNF-α/IL-33/ST2L signaling promotes gastric cancer metastasis. Oncogene. 2019;: pubmed publisher
flow cytometry; human; loading ...; fig s2b	Yeap W, Wong K, Shimasaki N, Teo E, Quek J, Yong H, et al. CD16 is indispensable for antibody-dependent cellular cytotoxicity by human monocytes. Sci Rep. 2016;6:34310 pubmed publisher
	Minshawi F, White M, Muller W, Humphreys N, Jackson D, Campbell B, et al. Human TNF-Luc reporter mouse: A new model to quantify inflammatory responses. Sci Rep. 2019;9:193 pubmed publisher
	Monguió Tortajada M, Franquesa M, Sarrias M, Borras F. Low doses of LPS exacerbate the inflammatory response and trigger death on TLR3-primed human monocytes. Cell Death Dis. 2018;9:499 pubmed publisher
	Holdbrooks A, Britain C, Bellis S. ST6Gal-I sialyltransferase promotes tumor necrosis factor (TNF)-mediated cancer cell survival via sialylation of the TNF receptor 1 (TNFR1) death receptor. J Biol Chem. 2018;293:1610-1622 pubmed publisher
	Chakraborty A, Dorsett K, Trummell H, Yang E, Oliver P, Bonner J, et al. ST6Gal-I sialyltransferase promotes chemoresistance in pancreatic ductal adenocarcinoma by abrogating gemcitabine-mediated DNA damage. J Biol Chem. 2018;293:984-994 pubmed publisher
	Ross S, Sherman M, McElroy P, Lofgren J, Moody G, Baeuerle P, et al. Bispecific T cell engager (BiTE®) antibody constructs can mediate bystander tumor cell killing. PLoS ONE. 2017;12:e0183390 pubmed publisher
	Morton P, Hicks A, Ortiz Zapater E, Raghavan S, Pike R, Noble A, et al. TNFα promotes CAR-dependent migration of leukocytes across epithelial monolayers. Sci Rep. 2016;6:26321 pubmed publisher
	Sonoda Y, Gohda T, Suzuki Y, Omote K, Ishizaka M, Matsuoka J, et al. Circulating TNF receptors 1 and 2 are associated with the severity of renal interstitial fibrosis in IgA nephropathy. PLoS ONE. 2015;10:e0122212 pubmed publisher
	Mizrahi K, Ash S, Peled T, Yaniv I, Stein J, Askenasy N. Negative selection by apoptosis enriches progenitors in naïve and expanded human umbilical cord blood grafts. Bone Marrow Transplant. 2014;49:942-9 pubmed publisher
	Mizrahi K, Yaniv I, Ash S, Stein J, Askenasy N. Apoptotic signaling through Fas and TNF receptors ameliorates GVHD in mobilized peripheral blood grafts. Bone Marrow Transplant. 2014;49:640-8 pubmed publisher
	Garcin G, Paul F, Staufenbiel M, Bordat Y, Van der Heyden J, Wilmes S, et al. High efficiency cell-specific targeting of cytokine activity. Nat Commun. 2014;5:3016 pubmed publisher
	Nomura T, Aoyama M, Waguri Nagaya Y, Goto Y, Suzuki M, Miyazawa K, et al. Tumor necrosis factor stimulates osteoclastogenesis from human bone marrow cells under hypoxic conditions. Exp Cell Res. 2014;321:167-77 pubmed publisher
	El Hachmane M, Rees K, Veale E, Sumbayev V, Mathie A. Enhancement of TWIK-related acid-sensitive potassium channel 3 (TASK3) two-pore domain potassium channel activity by tumor necrosis factor ?. J Biol Chem. 2014;289:1388-401 pubmed publisher
	Neumann S, Bidon T, Branschädel M, Krippner Heidenreich A, Scheurich P, Doszczak M. The transmembrane domains of TNF-related apoptosis-inducing ligand (TRAIL) receptors 1 and 2 co-regulate apoptotic signaling capacity. PLoS ONE. 2012;7:e42526 pubmed publisher
	Renaud S, Sullivan R, Graham C. Tumour necrosis factor alpha stimulates the production of monocyte chemoattractants by extravillous trophoblast cells via differential activation of MAPK pathways. Placenta. 2009;30:313-9 pubmed publisher
	Maneechotesuwan K, Wamanuttajinda V, Kasetsinsombat K, Huabprasert S, Yaikwawong M, Barnes P, et al. Der p 1 suppresses indoleamine 2, 3-dioxygenase in dendritic cells from house dust mite-sensitive patients with asthma. J Allergy Clin Immunol. 2009;123:239-48 pubmed publisher
	Seal S, Hockenbery D, Spaulding E, Kiem H, Abbassi N, Deeg H. Differential responses of FLIPLong and FLIPShort-overexpressing human myeloid leukemia cells to TNF-alpha and TRAIL-initiated apoptotic signals. Exp Hematol. 2008;36:1660-72 pubmed publisher
	Kolliputi N, Waxman A. IL-6 cytoprotection in hyperoxic acute lung injury occurs via suppressor of cytokine signaling-1-induced apoptosis signal-regulating kinase-1 degradation. Am J Respir Cell Mol Biol. 2009;40:314-24 pubmed publisher
	Dong H, Kleinberg L, Silins I, Flørenes V, Trope C, Risberg B, et al. Death receptor expression is associated with poor response to chemotherapy and shorter survival in metastatic ovarian carcinoma. Cancer. 2008;112:84-93 pubmed
	Ebert E, Mehta V. Human intestinal intraepithelial lymphocytes keep TNF alpha levels low by cell uptake and feedback inhibition of transcription. Cell Immunol. 2006;241:7-13 pubmed
	Georgopoulos N, Steele L, Thomson M, Selby P, Southgate J, Trejdosiewicz L. A novel mechanism of CD40-induced apoptosis of carcinoma cells involving TRAF3 and JNK/AP-1 activation. Cell Death Differ. 2006;13:1789-801 pubmed
	Clarke D, Branton R. A role for tumor necrosis factor alpha in death of dopaminergic neurons following neural transplantation. Exp Neurol. 2002;176:154-62 pubmed

product information

brand :

R&D Systems

master code :

MAB225

SKU :

MAB225-100

product name :

Human TNF RI/TNFRSF1A Antibody

description :

The Human TNF RI/TNFRSF1A Antibody from R&D Systems is a mouse monoclonal antibody to TNF RI/TNFRSF1A. This antibody reacts with human. The Human TNF RI/TNFRSF1A Antibody has been validated for the following applications: Western Blot, Flow Cytometry, Neutralization, CyTOF-ready.

target :

TNF RI/TNFRSF1A

category :

Primary Antibodies

unit size :

100 ug (also 25 ug, 500 ug)

buffer :

Lyophilized from a 0.2 µm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied as a 0.2 µm filtered solution in PBS.

clonality :

Monoclonal

clone :

16803

conjugate :

Unconjugated

host :

Mouse

immunogen :

E. coli -derived recombinant human TNF RI/TNFRSF1A, Accession # NP_001056

isotype :

IgG1

purity :

Protein A or G purified from ascites

species :

Human

specificity :

Detects human TNF RI in Western blots. In Western blots, does not cross-react with recombinant human (rh) TNF RII, rmTNF RI, or rmTNF RII.

gene symbol :

TNFRSF1A

endotoxin note :

<0.10 EU per 1 µg of the antibody by the LAL method.

catalog number base :

MAB225

accessionNumbers :

NP_001056

applications :

Western Blot, Flow Cytometry, Neutralization, CyTOF-ready

2020 USD :

339

2021 USD :

369 USD

alt names :

CD120a, CD120a antigen, FPF, p55, p55-R, p60, TNFARMGC19588, TNF-R, TNF-R1, TNFR1TBP1, TNFR55, TNF-R55, TNFR60, TNFRI, TNF-RI, TNF-R-I, TNFR-I, TNFRSF1A, tumor necrosis factor binding protein 1, Tumor necrosis factor receptor 1, tumor necrosis factor receptor 1A isoform beta, tumor necrosis factor receptor superfamily member 1A, tumor necrosis factor receptor superfamily, member 1A, tumor necrosis factor receptor type 1, Tumor necrosis factor receptor type I, tumor necrosis factor-alpha receptor

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 6 months, -20 to -70 °C under sterile conditions after reconstitution.