Human BRCA1 C-Terminus Antibody | R&D Systems MAB22101 product information

product summary

company name :

R&D Systems

product type :

antibody

product name :

Human BRCA1 C-Terminus Antibody

catalog :

MAB22101

quantity :

100 ug (also 25 ug)

price :

479 USD

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

440621

reactivity :

human, mouse

application :

western blot, immunohistochemistry, immunoprecipitation, flow cytometry

more info or order :

R&D Systems product webpage

citations: 11

Reference
Guo Y, Chomiak A, Hong Y, Lowe C, Kopsidas C, Chan W, et al. Histone H2A ubiquitination resulting from Brap loss of function connects multiple aging hallmarks and accelerates neurodegeneration. iScience. 2022;25:104519 pubmed publisher
Chomiak A, Guo Y, Kopsidas C, McDaniel D, Lowe C, Pan H, et al. Nde1 is required for heterochromatin compaction and stability in neocortical neurons. iScience. 2022;25:104354 pubmed publisher
Mirman Z, Sasi N, King A, Chapman J, de Lange T. 53BP1-shieldin-dependent DSB processing in BRCA1-deficient cells requires CST-Polα-primase fill-in synthesis. Nat Cell Biol. 2022;24:51-61 pubmed publisher
Yang J, Qi L, Chiang H, Yuan B, Li R, Hu Y. BRCA1 Antibodies Matter. Int J Biol Sci. 2021;17:3239-3254 pubmed publisher
Mirman Z, Lottersberger F, Takai H, Kibe T, Gong Y, Takai K, et al. 53BP1-RIF1-shieldin counteracts DSB resection through CST- and Polα-dependent fill-in. Nature. 2018;560:112-116 pubmed publisher
Maifrede S, Nieborowska Skorska M, Sullivan K, Dasgupta Y, Podszywalow Bartnicka P, Le B, et al. Tyrosine kinase inhibitor-induced defects in DNA repair sensitize FLT3(ITD)-positive leukemia cells to PARP1 inhibitors. Blood. 2018;: pubmed publisher
Maifrede S, Martin K, Podszywalow Bartnicka P, Sullivan Reed K, Langer S, Nejati R, et al. IGH/MYC Translocation Associates with BRCA2 Deficiency and Synthetic Lethality to PARP1 Inhibitors. Mol Cancer Res. 2017;15:967-972 pubmed publisher
Nieborowska Skorska M, Sullivan K, Dasgupta Y, Podszywalow Bartnicka P, Hoser G, Maifrede S, et al. Gene expression and mutation-guided synthetic lethality eradicates proliferating and quiescent leukemia cells. J Clin Invest. 2017;127:2392-2406 pubmed publisher
Shapiro A, Miller Pinsler L, Wells P. Breast cancer 1 (BRCA1)-deficient embryos develop normally but are more susceptible to ethanol-initiated DNA damage and embryopathies. Redox Biol. 2016;7:30-38 pubmed publisher
Kawai S, Amano A. BRCA1 regulates microRNA biogenesis via the DROSHA microprocessor complex. J Cell Biol. 2012;197:201-8 pubmed publisher
Wolanin K, Magalska A, Kusio Kobialka M, Podszywalow Bartnicka P, Vejda S, McKenna S, et al. Expression of oncogenic kinase Bcr-Abl impairs mitotic checkpoint and promotes aberrant divisions and resistance to microtubule-targeting agents. Mol Cancer Ther. 2010;9:1328-38 pubmed publisher

product information

master code :

MAB22101

SKU :

MAB22101

product name :

Human BRCA1 C-Terminus Antibody

unit size :

100 ug (also 25 ug)

description :

The Human BRCA1 C-Terminus Antibody from R&D Systems is a mouse monoclonal antibody to BRCA1. This antibody reacts with human,mouse. The Human BRCA1 C-Terminus Antibody has been validated for the following applications: Western Blot,Flow Cytometry,Immunoprecipitation,Immunohistochemistry.

target :

BRCA1

category :

Primary Antibodies

buffer :

Lyophilized from a 0.2 ╡m filtered solution in PBS with Trehalose. See Certificate of Analysis for details. *Small pack size (-SP) is supplied either lyophilized or as a 0.2 ╡m filtered solution in PBS.

clonality :

Monoclonal

clone :

440621

concentration :

LYOPH

conjugate :

Unconjugated

host :

Mouse

immunogen :

E. coli -derived recombinant human BRCA1 C-Terminus, Arg1634-Tyr1863, Accession # P38398

isotype :

IgG2b

purity :

Protein A or G purified from hybridoma culture supernatant

species :

Human,Mouse

specificity :

Detects human BRCA1 C-Terminus.

gene symbol :

BRCA1

top caption :

BRCA1 antibody in Human Breast Cancer Tissue by Immunohistochemistry (IHC-P).

accessionNumbers :

P38398

applications :

Western Blot,Flow Cytometry,Immunoprecipitation,Immunohistochemistry

USD :

479 USD

alt names :

BRCAI, breast and ovarian cancer susceptibility protein 1, breast and ovarian cancer sususceptibility protein, breast cancer 1, early onset, breast cancer type 1 susceptibility protein, EC 6.3.2, EC 6.3.2.-, IRIS, PNCA4, PSCP, subunit 1

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 6 months, -20 to -70 ░C under sterile conditions after reconstitution.

more info or order :

R&D Systems product webpage