Human IL-11 Antibody | R&D Systems MAB218 product information

product summary

company name :

R&D Systems

product type :

antibody

product name :

Human IL-11 Antibody

catalog :

MAB218

quantity :

500 ug (also 25 ug)

price :

579 USD

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

22626

reactivity :

human, mouse

application :

western blot, neutralization

more info or order :

R&D Systems product webpage

citations: 15

Published Application/Species/Sample/Dilution	Reference
western blot; mouse; fig 4a	Guo Y, Lu Y, Lu X, He S, Li S, Shao S, et al. Krüppel-Like Factor 15/Interleukin 11 Axis-Mediated Adventitial Remodeling Depends on Extracellular Signal-Regulated Kinases 1 and 2 Activation in Angiotensin II-Induced Hypertension. J Am Heart Assoc. 2021;10:e020554 pubmed publisher
	Tang T, Yang T, Xue H, Liu X, Yu J, Liang C, et al. Breast cancer stem cell-derived exosomal lnc-PDGFD induces fibroblast-niche formation and promotes lung metastasis. Oncogene. 2025;44:601-617 pubmed publisher
	Sweeney M, O Fee K, Villanueva Hayes C, Rahman E, Lee M, Vanezis K, et al. Cardiomyocyte-Restricted Expression of IL11 Causes Cardiac Fibrosis, Inflammation, and Dysfunction. Int J Mol Sci. 2023;24: pubmed publisher
	Widjaja A, Viswanathan S, Shekeran S, Adami E, Lim W, Chothani S, et al. Targeting endogenous kidney regeneration using anti-IL11 therapy in acute and chronic models of kidney disease. Nat Commun. 2022;13:7497 pubmed publisher
	Widjaja A, Viswanathan S, Jinrui D, Singh B, Tan J, Wei Ting J, et al. Molecular Dissection of Pro-Fibrotic IL11 Signaling in Cardiac and Pulmonary Fibroblasts. Front Mol Biosci. 2021;8:740650 pubmed publisher
	Działo E, Czepiel M, Tkacz K, Siedlar M, Kania G, Błyszczuk P. WNT/β-Catenin Signaling Promotes TGF-β-Mediated Activation of Human Cardiac Fibroblasts by Enhancing IL-11 Production. Int J Mol Sci. 2021;22: pubmed publisher
	Chen Z, Chen X, Xie R, Huang M, Dong W, Han J, et al. DANCR Promotes Metastasis and Proliferation in Bladder Cancer Cells by Enhancing IL-11-STAT3 Signaling and CCND1 Expression. Mol Ther. 2019;27:326-341 pubmed publisher
	Zhao M, Liu Y, Liu R, Qi J, Hou Y, Chang J, et al. Upregulation of IL-11, an IL-6 Family Cytokine, Promotes Tumor Progression and Correlates with Poor Prognosis in Non-Small Cell Lung Cancer. Cell Physiol Biochem. 2018;45:2213-2224 pubmed publisher
	Schafer S, Viswanathan S, Widjaja A, Lim W, Moreno Moral A, Delaughter D, et al. IL-11 is a crucial determinant of cardiovascular fibrosis. Nature. 2017;552:110-115 pubmed publisher
	Sano E, Takei T, Ueda T, Tsumoto K. Production and characterization of genetically modified human IL-11 variants. Biochim Biophys Acta Gen Subj. 2017;1861:205-217 pubmed publisher
	Zhou C, Ji J, Cai Q, Shi M, Chen X, Yu Y, et al. MTA2 enhances colony formation and tumor growth of gastric cancer cells through IL-11. BMC Cancer. 2015;15:343 pubmed publisher
	Kim J, Kim M, Ham A, Brown K, Greene R, D Agati V, et al. IL-11 is required for A1 adenosine receptor-mediated protection against ischemic AKI. J Am Soc Nephrol. 2013;24:1558-70 pubmed publisher
	Onnis B, Fer N, Rapisarda A, Perez V, Melillo G. Autocrine production of IL-11 mediates tumorigenicity in hypoxic cancer cells. J Clin Invest. 2013;123:1615-29 pubmed publisher
	Bockhorn J, Dalton R, Nwachukwu C, Huang S, Prat A, Yee K, et al. MicroRNA-30c inhibits human breast tumour chemotherapy resistance by regulating TWF1 and IL-11. Nat Commun. 2013;4:1393 pubmed publisher
	Lee K, Kalantzis A, Jackson C, O Connor L, Murata Kamiya N, Hatakeyama M, et al. Helicobacter pylori CagA triggers expression of the bactericidal lectin REG3? via gastric STAT3 activation. PLoS ONE. 2012;7:e30786 pubmed publisher

product information

master code :

MAB218

SKU :

MAB218

product name :

Human IL-11 Antibody

unit size :

500 ug (also 25 ug)

description :

The Human IL-11 Antibody from R&D Systems is a mouse monoclonal antibody to IL-11. This antibody reacts with human,mouse,xenograft. The Human IL-11 Antibody has been validated for the following applications: Neutralization,Inhibition,Western Blot.

target :

IL-11

category :

Primary Antibodies

buffer :

Lyophilized from a 0.2 ╡m filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 ╡m filtered solution in PBS.

clonality :

Monoclonal

clone :

22626

conjugate :

Unconjugated

host :

Mouse

immunogen :

E. coli -derived recombinant human IL-11, Pro22-Leu199, Accession # P20809

isotype :

IgG2a

purity :

Protein A or G purified from hybridoma culture supernatant

species :

Human,Mouse,Xenograft

specificity :

Detects human IL-11 in direct ELISAs and Western blots. In direct ELISAs and Western blots, 100% cross-reactivity with recombinant mouse IL-11 is observed and no cross-reactivity with recombinant human (rh) IL-6, rhCNTF, rhLIF, rhOSM, rhCLC, or rhCT-1 is observed.

gene symbol :

IL11

endotoxin note :

<0.10 EU per 1 ╡g of the antibody by the LAL method.

top caption :

Cell Proliferation Induced by IL-11 and Neutralization by Human IL-11 Antibody.

accessionNumbers :

P20809

applications :

Neutralization,Inhibition,Western Blot

USD :

579 USD

alt names :

Adipogenesis inhibitory factor, AGIF, AGIFoprelvekin, IL11, IL-11Oprelvekin, interleukin 11, interleukin-11, Oprelvekin

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 6 months, -20 to -70 ░C under sterile conditions after reconstitution.

more info or order :

R&D Systems product webpage