Human IL-10 Antibody | R&D Systems MAB217-100 product information

product summary

company name :

R&D Systems

product type :

antibody

product name :

Human IL-10 Antibody

catalog :

MAB217-100

quantity :

100 ug (also 25 ug, 500 ug)

price :

489 USD

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

23738

reactivity :

human

application :

western blot, neutralization, flow cytometry

more info or order :

R&D Systems product webpage

citations: 30

Reference
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Dumigan A, Cappa O, Morris B, S xe1 Pessoa J, Calderón Gonzalez R, Mills G, et al. In vivo single-cell transcriptomics reveal Klebsiella pneumoniae skews lung macrophages to promote infection. EMBO Mol Med. 2022;14:e16888 pubmed publisher
Shankar S, Stolp J, Juvet S, Beckett J, Macklin P, Issa F, et al. Ex vivo-expanded human CD19+TIM-1+ regulatory B cells suppress immune responses in vivo and are dependent upon the TIM-1/STAT3 axis. Nat Commun. 2022;13:3121 pubmed publisher
Fukasawa T, Yoshizaki A, Ebata S, Yoshizaki Ogawa A, Asano Y, Enomoto A, et al. Single-cell-level protein analysis revealing the roles of autoantigen-reactive B lymphocytes in autoimmune disease and the murine model. elife. 2021;10: pubmed publisher
Saha A, Ben Halima H, Saini A, Gallardo Gonzalez J, Zine N, Vi xf1 as C, et al. Magnetic Nanoparticles Fishing for Biomarkers in Artificial Saliva. Molecules. 2020;25: pubmed publisher
Duarte Neto A, Croda J, Pagliari C, Soriano F, Nicodemo A, Duarte M. Severe Leptospirosis Features in the Spleen Indicate Cellular Immunosuppression Similar to That Found in Septic Shock. Front Immunol. 2019;10:920 pubmed publisher
Brekke K, Sommerfelt M, Okvist M, Dyrhol Riise A, Kvale D. The therapeutic HIV Env C5/gp41 vaccine candidate Vacc-C5 induces specific T cell regulation in a phase I/II clinical study. BMC Infect Dis. 2017;17:228 pubmed publisher
Hock B, MacPherson S, McKenzie J. Idelalisib and caffeine reduce suppression of T cell responses mediated by activated chronic lymphocytic leukemia cells. PLoS ONE. 2017;12:e0172858 pubmed publisher
Huynh L, Kusnadi A, Park S, Murata K, Park Min K, Ivashkiv L. Opposing regulation of the late phase TNF response by mTORC1-IL-10 signaling and hypoxia in human macrophages. Sci Rep. 2016;6:31959 pubmed publisher
Castellano L, Argiro L, Dessein H, Dessein A, da Silva M, Correia D, et al. Potential Use of Interleukin-10 Blockade as a Therapeutic Strategy in Human Cutaneous Leishmaniasis. J Immunol Res. 2015;2015:152741 pubmed publisher
Heine G, Drozdenko G, Grün J, Chang H, Radbruch A, Worm M. Autocrine IL-10 promotes human B-cell differentiation into IgM- or IgG-secreting plasmablasts. Eur J Immunol. 2014;44:1615-21 pubmed publisher
Herath S, Benlahrech A, Papagatsias T, Athanasopoulos T, Bouzeboudjen Z, Hervouet C, et al. Fusion of ubiquitin to HIV gag impairs human monocyte-derived dendritic cell maturation and reduces ability to induce gag T cell responses. PLoS ONE. 2014;9:e88327 pubmed publisher
Evans H, Roostalu U, Walter G, Gullick N, Frederiksen K, Roberts C, et al. TNF-? blockade induces IL-10 expression in human CD4+ T cells. Nat Commun. 2014;5:3199 pubmed publisher
Flynn J, Dore G, Hellard M, Yeung B, Rawlinson W, White P, et al. Maintenance of Th1 hepatitis C virus (HCV)-specific responses in individuals with acute HCV who achieve sustained virological clearance after treatment. J Gastroenterol Hepatol. 2013;28:1770-81 pubmed publisher
R Viso A, Duarte M, Pagliari C, Fernandes E, Brasil R, Benard G, et al. Tissue and serum immune response in chronic hepatitis C with mild histological lesions. Mem Inst Oswaldo Cruz. 2010;105:25-32 pubmed
Dubicke A, Fransson E, Centini G, Andersson E, Bystr xf6 m B, Malmstr xf6 m A, et al. Pro-inflammatory and anti-inflammatory cytokines in human preterm and term cervical ripening. J Reprod Immunol. 2010;84:176-85 pubmed publisher
Gruber S, Gloria Luciani M, Grundtner P, Zdanov A, Gasche C. Differential signaling of cmvIL-10 through common variants of the IL-10 receptor 1. Eur J Immunol. 2008;38:3365-75 pubmed publisher
Alatrakchi N, Graham C, van der Vliet H, Sherman K, Exley M, Koziel M. Hepatitis C virus (HCV)-specific CD8+ cells produce transforming growth factor beta that can suppress HCV-specific T-cell responses. J Virol. 2007;81:5882-92 pubmed
Bayry J, Triebel F, Kaveri S, Tough D. Human dendritic cells acquire a semimature phenotype and lymph node homing potential through interaction with CD4+CD25+ regulatory T cells. J Immunol. 2007;178:4184-93 pubmed
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Iliopoulou E, Karamouzis M, Missitzis I, Ardavanis A, Sotiriadou N, Baxevanis C, et al. Increased frequency of CD4+ cells expressing CD161 in cancer patients. Clin Cancer Res. 2006;12:6901-9 pubmed
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product information

brand :

R&D Systems

master code :

MAB217

SKU :

MAB217-100

product name :

Human IL-10 Antibody

unit size :

100 ug (also 25 ug, 500 ug)

seo description :

The Human IL-10 Antibody from R&D Systems is a mouse monoclonal antibody to IL-10. This antibody reacts with human. The Human IL-10 Antibody has been validated for the following applications: Neutralization,Affinity Chromatography,Blocking,ELISA Development (Capture),Luminex Development,Flow Cytometry,Western Blot,Simple Western.

target :

IL-10

category :

Primary Antibodies

buffer :

Lyophilized from a 0.2 ╡m filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 ╡m filtered solution in PBS.

clonality :

Monoclonal

clone :

23738

conjugate :

Unconjugated

dilution :

Western Blot 2 ug/mL, Simple Western 10 ug/mL, Neutralization

host :

Mouse

immunogen :

E. coli -derived recombinant human IL-10, Ser19-Asn178, Accession # P22301

isotype :

IgG2b

purity :

Protein A or G purified from hybridoma culture supernatant

species :

Human

specificity :

Detects human IL-10 in Western blots. In Western blots, this antibody shows approximately 5% cross-reactivity with recombinant mouse IL-10.

gene symbol :

IL10

endotoxin note :

<0.10 EU per 1 ╡g of the antibody by the LAL method.

top caption :

Detection of Human IL-10 antibody by Western Blot.

accessionNumbers :

P22301

applications :

Simple Western,Affinity Chromatography,Blocking,ELISA Development (Capture),Luminex Development,Flow Cytometry,Western Blot,Neutralization

USD :

489 USD

alt names :

CSIF, CSIFMGC126450, Cytokine synthesis inhibitory factor, GVHDS, IL10, IL10A, IL-10MGC126451, interleukin 10, interleukin-10, TGIF

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 6 months, -20 to -70 ░C under sterile conditions after reconstitution.

more info or order :

R&D Systems product webpage