product summary
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company name :
R&D Systems
product type :
antibody
product name :
Mouse CXCR4 Antibody
catalog :
MAB21651-100
quantity :
100 ug (also 25 ug, 500 ug)
price :
509 USD
clonality :
monoclonal
host :
rat
conjugate :
nonconjugated
clone name :
247506
reactivity :
human, mouse
application :
immunohistochemistry, immunocytochemistry, neutralization, flow cytometry, immunohistochemistry - paraffin section, immunohistochemistry - frozen section
more info or order :
citations: 44
Reference
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Narayan P, Bruce A, Rivera E, Bertram T, Jain D. Selected renal cells harbor nephrogenic potential. Front Med (Lausanne). 2022;9:1062890 pubmed publisher
Babst N, Isbell L, Rommel F, Tura A, Ranjbar M, Grisanti S, et al. CXCR4, CXCR5 and CD44 May Be Involved in Homing of Lymphoma Cells into the Eye in a Patient Derived Xenograft Homing Mouse Model for Primary Vitreoretinal Lymphoma. Int J Mol Sci. 2022;23: pubmed publisher
Xu Y, Wei Z, Feng M, Zhu D, Mei S, Wu Z, et al. Tumor-infiltrated activated B cells suppress liver metastasis of colorectal cancers. Cell Rep. 2022;40:111295 pubmed publisher
Dolan C, Imholt F, Yan M, Yang T, Gregory J, Qureshi O, et al. Digit specific denervation does not inhibit mouse digit tip regeneration. Dev Biol. 2022;486:71-80 pubmed publisher
Ridge L, Kewbank D, Schütz D, Stumm R, Scambler P, Ivins S. Dual role for CXCL12 signaling in semilunar valve development. Cell Rep. 2021;36:109610 pubmed publisher
Kim J, Lee S, Park K. CXCR4 Regulates Temporal Differentiation via PRC1 Complex in Organogenesis of Epithelial Glands. Int J Mol Sci. 2021;22: pubmed publisher
Seeger D, Golovko S, Grove B, Golovko M. Cyclooxygenase inhibition attenuates brain angiogenesis and independently decreases mouse survival under hypoxia. J Neurochem. 2021;158:246-261 pubmed publisher
Galeano Niño J, Pageon S, Tay S, Colakoglu F, Kempe D, Hywood J, et al. Cytotoxic T cells swarm by homotypic chemokine signalling. elife. 2020;9: pubmed publisher
Davidson S, Efremova M, Riedel A, Mahata B, Pramanik J, Huuhtanen J, et al. Single-Cell RNA Sequencing Reveals a Dynamic Stromal Niche That Supports Tumor Growth. Cell Rep. 2020;31:107628 pubmed publisher
Mcheik S, Van Eeckhout N, De Poorter C, Gal xe9 s C, Parmentier M, Springael J. Coexpression of CCR7 and CXCR4 During B Cell Development Controls CXCR4 Responsiveness and Bone Marrow Homing. Front Immunol. 2019;10:2970 pubmed publisher
Kalpana G, Figy C, Yeung M, Yeung K. Reduced RhoA expression enhances breast cancer metastasis with a concomitant increase in CCR5 and CXCR4 chemokines signaling. Sci Rep. 2019;9:16351 pubmed publisher
Capitano M, Mor Vaknin N, Saha A, Cooper S, Legendre M, Guo H, et al. Secreted nuclear protein DEK regulates hematopoiesis through CXCR2 signaling. J Clin Invest. 2019;129:2555-2570 pubmed publisher
Macoska J, Wang Z, Virta J, Zacharias N, Bjorling D. Inhibition of the CXCL12/CXCR4 axis prevents periurethral collagen accumulation and lower urinary tract dysfunction in vivo. Prostate. 2019;79:757-767 pubmed publisher
Lopez M, Seyed Razavi Y, Jamali A, Harris D, Hamrah P. The Chemokine Receptor CXCR4 Mediates Recruitment of CD11c+ Conventional Dendritic Cells Into the Inflamed Murine Cornea. Invest Ophthalmol Vis Sci. 2018;59:5671-5681 pubmed publisher
Dawson L, Schanes P, Kim P, Imholt F, Qureshi O, Dolan C, et al. Blastema formation and periosteal ossification in the regenerating adult mouse digit. Wound Repair Regen. 2018;26:263-273 pubmed publisher
Benedicto A, Romayor I, Arteta B. CXCR4 receptor blockage reduces the contribution of tumor and stromal cells to the metastatic growth in the liver. Oncol Rep. 2018;39:2022-2030 pubmed publisher
Nagashima H, Shinoda M, Honda K, Kamio N, Hasuike A, Sugano N, et al. CXCR4 signaling contributes to alveolar bone resorption in Porphyromonas gingivalis-induced periodontitis in mice. J Oral Sci. 2017;: pubmed publisher
Dawson L, Yu L, Yan M, Marrero L, Schanes P, Dolan C, et al. The periosteal requirement and temporal dynamics of BMP2-induced middle phalanx regeneration in the adult mouse. Regeneration (Oxf). 2017;4:140-150 pubmed publisher
Zhang M, Qiu L, Zhang Y, Xu D, Zheng J, Jiang L. CXCL12 enhances angiogenesis through CXCR7 activation in human umbilical vein endothelial cells. Sci Rep. 2017;7:8289 pubmed publisher
Saha A, Ahn S, Blando J, Su F, Kolonin M, DiGiovanni J. Proinflammatory CXCL12-CXCR4/CXCR7 Signaling Axis Drives Myc-Induced Prostate Cancer in Obese Mice. Cancer Res. 2017;77:5158-5168 pubmed publisher
Nagashima H, Shinoda M, Honda K, Kamio N, Watanabe M, Suzuki T, et al. CXCR4 signaling in macrophages contributes to periodontal mechanical hypersensitivity in Porphyromonas gingivalis-induced periodontitis in mice. Mol Pain. 2017;13:1744806916689269 pubmed publisher
Smith N, Pietrancosta N, Davidson S, Dutrieux J, Chauveau L, Cutolo P, et al. Natural amines inhibit activation of human plasmacytoid dendritic cells through CXCR4 engagement. Nat Commun. 2017;8:14253 pubmed publisher
Cho K, Yoon D, Qiu S, Danziger Z, Grill W, Wetsel W, et al. Loss of Ranbp2 in motoneurons causes disruption of nucleocytoplasmic and chemokine signaling, proteostasis of hnRNPH3 and Mmp28, and development of amyotrophic lateral sclerosis-like syndromes. Dis Model Mech. 2017;10:559-579 pubmed publisher
Moshfegh C, Aires L, Kisielow M, Vogel V. A gonogenic stimulated transition of mouse embryonic stem cells with enhanced control of diverse differentiation pathways. Sci Rep. 2016;6:25104 pubmed publisher
Unachukwu U, Warren A, Li Z, Mishra S, Zhou J, Sauane M, et al. Predicted molecular signaling guiding photoreceptor cell migration following transplantation into damaged retina. Sci Rep. 2016;6:22392 pubmed publisher
Chen Q, Zhang M, Li Y, Xu D, Wang Y, Song A, et al. CXCR7 Mediates Neural Progenitor Cells Migration to CXCL12 Independent of CXCR4. Stem Cells. 2015;33:2574-85 pubmed publisher
Spada R, Rojas J, Pérez Yagüe S, Mulens V, Cannata Ortiz P, Bragado R, et al. NKG2D ligand overexpression in lupus nephritis correlates with increased NK cell activity and differentiation in kidneys but not in the periphery. J Leukoc Biol. 2015;97:583-98 pubmed publisher
Butschkau A, Wagner N, Genz B, Vollmar B. Protein z exerts pro-angiogenic effects and upregulates CXCR4. PLoS ONE. 2014;9:e113554 pubmed publisher
Deniro M, Al Mohanna F. Nuclear factor kappa-B signaling is integral to ocular neovascularization in ischemia-independent microenvironment. PLoS ONE. 2014;9:e101602 pubmed publisher
Zgraggen S, Huggenberger R, Kerl K, Detmar M. An important role of the SDF-1/CXCR4 axis in chronic skin inflammation. PLoS ONE. 2014;9:e93665 pubmed publisher
Roy L, Sahraei M, Schettini J, Gruber H, Besmer D, Mukherjee P. Systemic neutralization of IL-17A significantly reduces breast cancer associated metastasis in arthritic mice by reducing CXCL12/SDF-1 expression in the metastatic niches. BMC Cancer. 2014;14:225 pubmed publisher
Kavanagh D, Yemm A, Zhao Y, Frampton J, Kalia N. Mechanisms of adhesion and subsequent actions of a haematopoietic stem cell line, HPC-7, in the injured murine intestinal microcirculation in vivo. PLoS ONE. 2013;8:e59150 pubmed publisher
Yang Q, Kim D, Kaucher A, Oatley M, Oatley J. CXCL12-CXCR4 signaling is required for the maintenance of mouse spermatogonial stem cells. J Cell Sci. 2013;126:1009-20 pubmed publisher
Köhler T, Reizis B, Johnson R, Weighardt H, Forster I. Influence of hypoxia-inducible factor 1? on dendritic cell differentiation and migration. Eur J Immunol. 2012;42:1226-36 pubmed publisher
Liu H, Liu S, Li Y, Wang X, Xue W, Ge G, et al. The role of SDF-1-CXCR4/CXCR7 axis in the therapeutic effects of hypoxia-preconditioned mesenchymal stem cells for renal ischemia/reperfusion injury. PLoS ONE. 2012;7:e34608 pubmed publisher
Salvucci O, Jiang K, Gasperini P, Maric D, Zhu J, Sakakibara S, et al. MicroRNA126 contributes to granulocyte colony-stimulating factor-induced hematopoietic progenitor cell mobilization by reducing the expression of vascular cell adhesion molecule 1. Haematologica. 2012;97:818-26 pubmed publisher
Rider P, Carmi Y, Guttman O, Braiman A, Cohen I, Voronov E, et al. IL-1? and IL-1? recruit different myeloid cells and promote different stages of sterile inflammation. J Immunol. 2011;187:4835-43 pubmed publisher
Liu H, Xue W, Ge G, Luo X, Li Y, Xiang H, et al. Hypoxic preconditioning advances CXCR4 and CXCR7 expression by activating HIF-1? in MSCs. Biochem Biophys Res Commun. 2010;401:509-15 pubmed publisher
Strasser G, Kaminker J, Tessier Lavigne M. Microarray analysis of retinal endothelial tip cells identifies CXCR4 as a mediator of tip cell morphology and branching. Blood. 2010;115:5102-10 pubmed publisher
Sengupta N, Afzal A, Caballero S, Chang K, Shaw L, Pang J, et al. Paracrine modulation of CXCR4 by IGF-1 and VEGF: implications for choroidal neovascularization. Invest Ophthalmol Vis Sci. 2010;51:2697-704 pubmed publisher
Schroeter M, Humboldt T, Schafer K, Konstantinides S. Rosuvastatin reduces atherosclerotic lesions and promotes progenitor cell mobilisation and recruitment in apolipoprotein E knockout mice. Atherosclerosis. 2009;205:63-73 pubmed publisher
Feng W, McCabe N, Mahabeleshwar G, Somanath P, Phillips D, Byzova T. The angiogenic response is dictated by beta3 integrin on bone marrow-derived cells. J Cell Biol. 2008;183:1145-57 pubmed publisher
Williams C, Segarra M, Sierra M, Sainson R, Tosato G, Harris A. Regulation of CXCR4 by the Notch ligand delta-like 4 in endothelial cells. Cancer Res. 2008;68:1889-95 pubmed publisher
product information
brand :
R&D Systems
master code :
MAB21651
SKU :
MAB21651-100
product name :
Mouse CXCR4 Antibody
unit size :
100 ug (also 25 ug, 500 ug)
seo description :
The Mouse CXCR4 Antibody from R&D Systems is a rat monoclonal antibody to CXCR4. This antibody reacts with human,mouse,rat,transgenic mouse. The Mouse CXCR4 Antibody has been validated for the following applications: Immunocytochemistry,Immunohistochemistry,Bioassay,Flow Cytometry,Neutralization,Immunohistochemistry-Paraffin,Immunohistochemistry-Frozen,In vivo assay,CyTOF-ready.
target :
CXCR4
category :
Primary Antibodies
buffer :
Lyophilized from a 0.2 ╡m filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 ╡m filtered solution in PBS.
clonality :
Monoclonal
clone :
247506
concentration :
LYOPH
conjugate :
Unconjugated
dilution :
Flow Cytometry 0.25 ug/10^6 cells, Immunohistochemistry 8-25 ug/mL, Neutralization 8-40 ug/mL, Immunocytochemistry 8-25 ug/mL, CyTOF-ready
host :
Rat
immunogen :
Y3 rat myeloid cell line transfected with mouse CXCR4, Met1-Ser359, Accession # P70658
isotype :
IgG2b
purity :
Protein A or G purified from hybridoma culture supernatant
species :
Human,Mouse,Transgenic Mouse
specificity :
Detects mouse CXCR4 transfectants. Does not stain irrelevant transfectants.
gene symbol :
CXCR4
endotoxin note :
<0.10 EU per 1 ╡g of the antibody by the LAL method.
top caption :
Detection of CXCR4 antibody in Mouse Thymocytes antibody by Flow Cytometry.
accessionNumbers :
P70658
applications :
CyTOF-ready,Bioassay,Flow Cytometry,Immunohistochemistry,Immunohistochemistry-Paraffin,Immunohistochemistry-Frozen,In vivo assay,Neutralization,Immunocytochemistry
USD :
509 USD
alt names :
CD184, chemokine (C-X-C motif) receptor 4, chemokine (C-X-C motif), receptor 4 (fusin), C-X-C chemokine receptor type 4, CXC-R4, CXCR-4, D2S201E, D2S201ESDF-1 receptor, FB22, Fusin, HM89, HM89NPYRL, HSY3RR, LAP3, LAP-3, LCR1, LESTR, LESTRCD184 antigen, Leukocyte-derived seven transmembrane domain receptor, leukocyte-derived seven-transmembrane-domain receptor, lipopolysaccharide-associated protein 3, neuropeptide Y receptor Y3, NPY3R, NPY3RWHIM, NPYR, NPYRL, NPYY3R, pCXCR4, seven transmembrane helix receptor, seven-transmembrane-segment receptor, spleen, Stromal cell-derived factor 1 receptor, WHIMS
storage :
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 6 months, -20 to -70 ░C under sterile conditions after reconstitution.
more info or order :
company information
R&D Systems
614 McKinley Place N.E.
Minneapolis, MN 55413
info@RnDSystems.com
https://www.rndsystems.com
800 343-7475
headquarters: USA
R&D Systems develops and manufactures high-quality proteins and serves as a world leader in immunoassays. R&D Systems also produces quality antibodies, antibody arrays, stem cell and cell culture products, and cell selection and detection products, serving the life science and diagnostics industry.