product summary
Loading...
company name :
R&D Systems
product type :
antibody
product name :
Human LDLR Antibody
catalog :
MAB2148-100
quantity :
100 ug (also 25 ug, 500 ug)
price :
489 USD
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
472413
reactivity :
human
application :
western blot, ELISA, immunohistochemistry, immunoprecipitation, flow cytometry
more info or order :
R&D Systems product webpage
citations: 13
Reference
Li W, Plante J, Lin C, Basu H, Plung J, Fan X, et al. Shifts in receptors during submergence of an encephalitic arbovirus. Nature. 2024;632:614-621 pubmed publisher
Pfisterer S, Brock I, Kanerva K, Hlushchenko I, Paavolainen L, Ripatti P, et al. Multiparametric platform for profiling lipid trafficking in human leukocytes. Cell Rep Methods. 2022;2:100166 pubmed publisher
Nava Salazar S, Flores Pliego A, P xe9 rez Mart xed nez G, Parra Hern xe1 ndez S, Vanoye Carlo A, Ibargüengoitia Ochoa F, et al. Resistin Modulates Low-Density Lipoprotein Cholesterol Uptake in Human Placental Explants via PCSK9. Reprod Sci. 2022;29:3242-3253 pubmed publisher
Clark L, Clark S, Lin C, Liu J, Coscia A, Nabel K, et al. VLDLR and ApoER2 are receptors for multiple alphaviruses. Nature. 2021;: pubmed publisher
Masuda Y, Yamaguchi S, Suzuki C, Aburatani T, Nagano Y, Miyauchi R, et al. Generation and Characterization of a Novel Small Biologic Alternative to Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9) Antibodies, DS-9001a, Albumin Binding Domain-Fused Anticalin Protein. J Pharmacol Exp Ther. 2018;365:368-378 pubmed publisher
Susan Resiga D, Girard E, Kiss R, Essalmani R, Hamelin J, Asselin M, et al. The Proprotein Convertase Subtilisin/Kexin Type 9-resistant R410S Low Density Lipoprotein Receptor Mutation: A NOVEL MECHANISM CAUSING FAMILIAL HYPERCHOLESTEROLEMIA. J Biol Chem. 2017;292:1573-1590 pubmed publisher
Weider E, Susan Resiga D, Essalmani R, Hamelin J, Asselin M, Nimesh S, et al. Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9) Single Domain Antibodies Are Potent Inhibitors of Low Density Lipoprotein Receptor Degradation. J Biol Chem. 2016;291:16659-71 pubmed publisher
Zanotelli M, Ardalani H, Zhang J, Hou Z, Nguyen E, Swanson S, et al. Stable engineered vascular networks from human induced pluripotent stem cell-derived endothelial cells cultured in synthetic hydrogels. Acta Biomater. 2016;35:32-41 pubmed publisher
Boucrot E, Ferreira A, Almeida Souza L, Debard S, Vallis Y, Howard G, et al. Endophilin marks and controls a clathrin-independent endocytic pathway. Nature. 2015;517:460-5 pubmed publisher
Amirache F, Levy C, Costa C, Mangeot P, Torbett B, Wang C, et al. Mystery solved: VSV-G-LVs do not allow efficient gene transfer into unstimulated T cells, B cells, and HSCs because they lack the LDL receptor. Blood. 2014;123:1422-4 pubmed publisher
Karta M, Wickert L, Curran C, Gavala M, Denlinger L, Gern J, et al. Allergen challenge in vivo alters rhinovirus-induced chemokine secretion from human airway macrophages. J Allergy Clin Immunol. 2014;133:1227-1230.e4 pubmed publisher
DeVay R, Shelton D, Liang H. Characterization of proprotein convertase subtilisin/kexin type 9 (PCSK9) trafficking reveals a novel lysosomal targeting mechanism via amyloid precursor-like protein 2 (APLP2). J Biol Chem. 2013;288:10805-18 pubmed publisher
Poirier S, Mayer G, Poupon V, McPherson P, Desjardins R, Ly K, et al. Dissection of the endogenous cellular pathways of PCSK9-induced low density lipoprotein receptor degradation: evidence for an intracellular route. J Biol Chem. 2009;284:28856-64 pubmed publisher
product information
master code :
MAB2148
SKU :
MAB2148-100
product name :
Human LDLR Antibody
unit size :
100 ug (also 25 ug, 500 ug)
description :
The Human LDLR Antibody from R&D Systems is a mouse monoclonal antibody to LDLR. This antibody reacts with human. The Human LDLR Antibody has been validated for the following applications: Flow Cytometry,ELISA Development,Western Blot,Functional Assay,ELISA Capture,Immunohistochemistry,Immunoprecipitation,ELISA Capture (Matched Antibody Pair),CyTOF-ready.
target :
LDLR
category :
Primary Antibodies
buffer :
Lyophilized from a 0.2 ╡m filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 ╡m filtered solution in PBS.
clonality :
Monoclonal
clone :
472413
conjugate :
Unconjugated
host :
Mouse
immunogen :
Chinese hamster ovary cell line CHO-derived recombinant human LDLR, Ala22-Arg788, Accession # P01130
isotype :
IgG1
purity :
Protein A or G purified from hybridoma culture supernatant
species :
Human
specificity :
Detects human LDLR in ELISAs and Western blots. In direct ELISAs and Western blots, no cross-reactivity with recombinant mouse (rm) LDLR, recombinant human LRP-5, or rmLRP-6 is observed.
gene symbol :
LDLR
top caption :
Detection of LDL R antibody in HepG2 Human Cell Line antibody by Flow Cytometry.
accessionNumbers :
P01130
applications :
Flow Cytometry,ELISA Development,Western Blot,Functional Assay,ELISA Capture,Immunohistochemistry,Immunoprecipitation,ELISA Capture (Matched Antibody Pair),CyTOF-ready
USD :
489 USD
alt names :
FH, FHC, LDL R, LDL receptor, LDLCQ2, low density lipoprotein receptor, low-density lipoprotein receptor, low-density lipoprotein receptor class A domain-containing protein 3
storage :
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 6 months, -20 to -70 ░C under sterile conditions after reconstitution.
more info or order :
R&D Systems product webpage
company information
R&D Systems
614 McKinley Place N.E.
Minneapolis, MN 55413
info@RnDSystems.com
https://www.rndsystems.com
800 343-7475
headquarters: USA
R&D Systems develops and manufactures high-quality proteins and serves as a world leader in immunoassays. R&D Systems also produces quality antibodies, antibody arrays, stem cell and cell culture products, and cell selection and detection products, serving the life science and diagnostics industry.