Human CHL-1/L1CAM-2 Antibody | R&D Systems MAB2126 product information

product summary

company name :

R&D Systems

product type :

antibody

product name :

Human CHL-1/L1CAM-2 Antibody

catalog :

MAB2126

quantity :

100 ug (also 25 ug)

price :

439 USD

clonality :

monoclonal

host :

rat

conjugate :

nonconjugated

clone name :

316223

reactivity :

human, mouse

application :

western blot, ELISA, immunohistochemistry, immunocytochemistry, neutralization

more info or order :

R&D Systems product webpage

citations: 7

Reference
Simoes S, Neufeld J, Triana Baltzer G, Moughadam S, Chen E, Kothiya M, et al. Tau and other proteins found in Alzheimer's disease spinal fluid are linked to retromer-mediated endosomal traffic in mice and humans. Sci Transl Med. 2020;12: pubmed publisher
Lin W, Ou G, Lin J, Yi S, Yao W, Pan H, et al. Neuregulin 1 enhances cell adhesion molecule L1 like expression levels and promotes malignancy in human glioma. Oncol Lett. 2020;20:326-336 pubmed publisher
Karstens K, Bellon E, Polonski A, Wolters Eisfeld G, Melling N, Reeh M, et al. Expression and serum levels of the neural cell adhesion molecule L1-like protein (CHL1) in gastrointestinal stroma tumors (GIST) and its prognostic power. Oncotarget. 2020;11:1131-1140 pubmed publisher
Kotani N, Yamaguchi A, Ohnishi T, Kuwahara R, Nakano T, Nakano Y, et al. Proximity proteomics identifies cancer cell membrane cis-molecular complex as a potential cancer target. Cancer Sci. 2019;110:2607-2619 pubmed publisher
Kim W, Ma L, Lomoio S, Willen R, Lombardo S, Dong J, et al. BACE1 elevation engendered by GGA3 deletion increases β-amyloid pathology in association with APP elevation and decreased CHL1 processing in 5XFAD mice. Mol Neurodegener. 2018;13:6 pubmed publisher
Yang Z, Xie Q, Hu C, Jiang Q, Shen H, Schachner M, et al. CHL1 Is Expressed and Functions as a Malignancy Promoter in Glioma Cells. Front Mol Neurosci. 2017;10:324 pubmed publisher
Wolterink S, Moldenhauer G, Fogel M, Kiefel H, Pfeifer M, Lüttgau S, et al. Therapeutic antibodies to human L1CAM: functional characterization and application in a mouse model for ovarian carcinoma. Cancer Res. 2010;70:2504-15 pubmed publisher

product information

master code :

MAB2126

SKU :

MAB2126

product name :

Human CHL-1/L1CAM-2 Antibody

unit size :

100 ug (also 25 ug)

description :

The Human CHL-1/L1CAM-2 Antibody from R&D Systems is a rat monoclonal antibody to CHL-1/L1CAM-2. This antibody reacts with human,mouse. The Human CHL-1/L1CAM-2 Antibody has been validated for the following applications: Immunohistochemistry,Blocking,Western Blot,ELISA Capture,Immunocytochemistry.

target :

CHL-1/L1CAM-2

category :

Primary Antibodies

buffer :

Lyophilized from a 0.2 ╡m filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 ╡m filtered solution in PBS.

clonality :

Monoclonal

clone :

316223

concentration :

LYOPH

conjugate :

Unconjugated

host :

Rat

immunogen :

Mouse myeloma cell line NS0-derived recombinant human CHL-1/L1CAM-2, Ile25-Gln1096, Accession # NP_006605

isotype :

IgG1

purity :

Protein A or G purified from hybridoma culture supernatant

species :

Human,Mouse

specificity :

Detects human CHL-1/L1CAM-2 in direct ELISAs and Western blots. In direct ELISAs and Western blots, no cross-reactivity with recombinant mouse CHL-1 is observed.

gene symbol :

CHL1

accessionNumbers :

NP_006605

applications :

Immunohistochemistry,Blocking,Western Blot,ELISA Capture,Immunocytochemistry

USD :

439 USD

alt names :

CALL, CALLClose homolog of L1, cell adhesion molecule with homology to L1CAM (close homolog of L1), cell adhesion molecule with homology to L1CAM (close homologue of L1), CHL1, FLJ44930, L1CAM-2, L1CAM2L1 cell adhesion molecule 2, MGC132578, neural cell adhesion molecule L1-like protein

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 6 months, -20 to -70 ░C under sterile conditions after reconstitution.

more info or order :

R&D Systems product webpage