Human TNF-alpha Antibody | R&D Systems MAB210 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

R&D Systems

product type :

antibody

product name :

Human TNF-alpha Antibody

catalog :

MAB210

quantity :

100 ug (also 25 ug, 500 ug)

price :

369 USD

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

1825

reactivity :

human

application :

western blot, neutralization, blocking or activating experiments

citations: 14

Published Application/Species/Sample/Dilution	Reference
blocking or activating experiments; human; 1 ug/ml; fig 4n	Cassetta L, Fragkogianni S, Sims A, Swierczak A, Forrester L, Zhang H, et al. Human Tumor-Associated Macrophage and Monocyte Transcriptional Landscapes Reveal Cancer-Specific Reprogramming, Biomarkers, and Therapeutic Targets. Cancer Cell. 2019;35:588-602.e10 pubmed publisher
western blot; human; loading ...; fig 6	Zhao L, Sun T, Wang L. Chitosan oligosaccharide improves the therapeutic efficacy of sitagliptin for the therapy of Chinese elderly patients with type 2 diabetes mellitus. Ther Clin Risk Manag. 2017;13:739-750 pubmed publisher
	Reuschl A, Edwards M, Parker R, Connell D, Hoang L, Halliday A, et al. Innate activation of human primary epithelial cells broadens the host response to Mycobacterium tuberculosis in the airways. PLoS Pathog. 2017;13:e1006577 pubmed publisher
	Uebele J, Stein C, Nguyen M, Schneider A, Kleinert F, Ticha O, et al. Antigen delivery to dendritic cells shapes human CD4+ and CD8+ T cell memory responses to Staphylococcus aureus. PLoS Pathog. 2017;13:e1006387 pubmed publisher
	Seeger P, Bosisio D, Parolini S, Badolato R, Gismondi A, Santoni A, et al. Activin A as a mediator of NK-dendritic cell functional interactions. J Immunol. 2014;192:1241-8 pubmed publisher
	Corvaisier M, Delneste Y, Jeanvoine H, Preisser L, Blanchard S, Garo E, et al. IL-26 is overexpressed in rheumatoid arthritis and induces proinflammatory cytokine production and Th17 cell generation. PLoS Biol. 2012;10:e1001395 pubmed publisher
	Nicolaidou V, Wong M, Redpath A, Ersek A, Baban D, Williams L, et al. Monocytes induce STAT3 activation in human mesenchymal stem cells to promote osteoblast formation. PLoS ONE. 2012;7:e39871 pubmed publisher
	Navenot J, Fujii N, Peiper S. KiSS1 metastasis suppressor gene product induces suppression of tyrosine kinase receptor signaling to Akt, tumor necrosis factor family ligand expression, and apoptosis. Mol Pharmacol. 2009;75:1074-83 pubmed publisher
	Arnold R, Neumann M, König W. Peroxisome proliferator-activated receptor-gamma agonists inhibit respiratory syncytial virus-induced expression of intercellular adhesion molecule-1 in human lung epithelial cells. Immunology. 2007;121:71-81 pubmed
	van Grevenstein W, Hofland L, van Rossen M, van Koetsveld P, Jeekel J, van Eijck C. Inflammatory cytokines stimulate the adhesion of colon carcinoma cells to mesothelial monolayers. Dig Dis Sci. 2007;52:2775-83 pubmed
	Pontikoglou C, Liapakis G, Pyrovolaki K, Papadakis M, Bux J, Eliopoulos G, et al. Evidence for downregulation of erythropoietin receptor in bone marrow erythroid cells of patients with chronic idiopathic neutropenia. Exp Hematol. 2006;34:1312-22 pubmed
	Ebert E, Mehta V. Human intestinal intraepithelial lymphocytes keep TNF alpha levels low by cell uptake and feedback inhibition of transcription. Cell Immunol. 2006;241:7-13 pubmed
	Tay S, McCormack A, Rose M. Effect of cognate human CD4+ T cell and endothelial cell interactions upon chemokine production. Transplantation. 2004;78:987-94 pubmed
	Albanesi C, Scarponi C, Sebastiani S, Cavani A, Federici M, Sozzani S, et al. A cytokine-to-chemokine axis between T lymphocytes and keratinocytes can favor Th1 cell accumulation in chronic inflammatory skin diseases. J Leukoc Biol. 2001;70:617-23 pubmed

product information

brand :

R&D Systems

master code :

MAB210

SKU :

MAB210-100

product name :

Human TNF-alpha Antibody

description :

The Human TNF-alpha Antibody from R&D Systems is a mouse monoclonal antibody to TNF-alpha. This antibody reacts with human. The Human TNF-alpha Antibody has been validated for the following applications: Neutralization.

target :

TNF-alpha

category :

Primary Antibodies

unit size :

100 ug (also 25 ug, 500 ug)

buffer :

Lyophilized from a 0.2 µm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied as a 0.2 µm filtered solution in PBS.

clonality :

Monoclonal

clone :

1825

concentration :

LYOPH

conjugate :

Unconjugated

host :

Mouse

immunogen :

E. coli -derived recombinant human TNF-alpha , Gly57-Leu233, Accession # P01375

isotype :

IgG1

purity :

Protein A or G purified from ascites

species :

Human

specificity :

Detects human TNF-alpha in direct ELISAs. In direct ELISAs, approximately 50% cross-reactivity with recombinant rhesus macaque TNF-alpha is observed and no cross-reactivity with recombinant cotton rat, mouse, rat, or porcine TNF-alpha is observed. It shows no cross-reactivity with recombinant human (rh) APRIL, rhBAFF, rhEDA-A2, rhFas Ligand, rhGITR Ligand, rhLIGHT, rhOX40 Ligand, rhRANK Ligand, rhTNF-beta , rhTRAIL, rhTRANCE, rhTWEAK, or rhVEGI.

gene symbol :

TNF

endotoxin note :

<0.10 EU per 1 µg of the antibody by the LAL method.

catalog number base :

MAB210

accessionNumbers :

P01375

applications :

Neutralization

2020 USD :

339

2021 USD :

369 USD

alt names :

APC1 protein, Cachectin, Cachetin, DIF, TNF, TNF, monocyte-derived, TNF-a, TNFA, TNFalpha, TNF-alphacachectin, TNFATNF, macrophage-derived, TNFG1F, TNFSF1A, TNFSF2, TNFSF2TNF superfamily, member 2, tumor necrosis factor, tumor necrosis factor (TNF superfamily, member 2), tumor necrosis factor alpha, Tumor necrosis factor ligand superfamily member 2, tumor necrosis factor-alpha

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 6 months, -20 to -70 °C under sterile conditions after reconstitution.