Human IL-6 Antibody | R&D Systems MAB2061 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

R&D Systems

product type :

antibody

product name :

Human IL-6 Antibody

catalog :

MAB2061

quantity :

100 ug (also 25 ug, 500 ug)

price :

369 USD

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

1936

reactivity :

human

application :

immunohistochemistry, immunocytochemistry, neutralization, flow cytometry, immunohistochemistry - paraffin section, blocking or activating experiments

citations: 24

Published Application/Species/Sample/Dilution	Reference
blocking or activating experiments; human; 5 ug/ml; loading ...; fig 3d	Eyre R, Alferez D, Santiago Gómez A, Spence K, McConnell J, Hart C, et al. Microenvironmental IL1β promotes breast cancer metastatic colonisation in the bone via activation of Wnt signalling. Nat Commun. 2019;10:5016 pubmed publisher
blocking or activating experiments; human; loading ...; fig 6e	Oon S, Huynh H, Tai T, Ng M, Monaghan K, Biondo M, et al. A cytotoxic anti-IL-3Rα antibody targets key cells and cytokines implicated in systemic lupus erythematosus. JCI Insight. 2016;1:e86131 pubmed publisher
blocking or activating experiments; human; loading ...; fig 6a	Knobloch J, Yanik S, Körber S, Stoelben E, Jungck D, Koch A. TNF?-induced airway smooth muscle cell proliferation depends on endothelin receptor signaling, GM-CSF and IL-6. Biochem Pharmacol. 2016;116:188-99 pubmed publisher
flow cytometry; human; loading ...; fig 2g	Piancone F, Saresella M, Marventano I, La Rosa F, Zoppis M, Agostini S, et al. B Lymphocytes in Multiple Sclerosis: Bregs and BTLA/CD272 Expressing-CD19+ Lymphocytes Modulate Disease Severity. Sci Rep. 2016;6:29699 pubmed publisher
blocking or activating experiments; human; loading ...; fig 3d	Cheng W, van Asten S, Burns L, Evans H, Walter G, Hashim A, et al. Periodontitis-associated pathogens P. gingivalis and A. actinomycetemcomitans activate human CD14(+) monocytes leading to enhanced Th17/IL-17 responses. Eur J Immunol. 2016;46:2211-21 pubmed publisher
immunohistochemistry - paraffin section; human; loading ...; fig 2b	Kobawala T, Trivedi T, Gajjar K, Patel D, Patel G, Ghosh N. Significance of Interleukin-6 in Papillary Thyroid Carcinoma. J Thyroid Res. 2016;2016:6178921 pubmed publisher
immunohistochemistry - paraffin section; human; loading ...; fig 1	Jhaveri K, Teplinsky E, Silvera D, Valeta Magara A, Arju R, Giashuddin S, et al. Hyperactivated mTOR and JAK2/STAT3 Pathways: Molecular Drivers and Potential Therapeutic Targets of Inflammatory and Invasive Ductal Breast Cancers After Neoadjuvant Chemotherapy. Clin Breast Cancer. 2016;16:113-22.e1 pubmed publisher
	Ashander L, Lie S, Ma Y, Rochet E, Washington J, Furtado J, et al. Neutrophil Activities in Human Ocular Toxoplasmosis: An In Vitro Study With Human Cells. Invest Ophthalmol Vis Sci. 2019;60:4652-4660 pubmed publisher
	Huang H, Zhang Y, Gallegos V, Sorrelle N, Zaid M, Toombs J, et al. Targeting TGFβR2-mutant tumors exposes vulnerabilities to stromal TGFβ blockade in pancreatic cancer. EMBO Mol Med. 2019;11:e10515 pubmed publisher
	Shokri M, Bozorgmehr M, Ghanavatinejad A, Falak R, Aleahmad M, Kazemnejad S, et al. Human menstrual blood-derived stromal/stem cells modulate functional features of natural killer cells. Sci Rep. 2019;9:10007 pubmed publisher
	Blanchette Farra N, Kita D, Konstorum A, Tesfay L, Lemler D, Hegde P, et al. Contribution of three-dimensional architecture and tumor-associated fibroblasts to hepcidin regulation in breast cancer. Oncogene. 2018;37:4013-4032 pubmed publisher
	Hjort M, Hov H, Abdollahi P, Vandsemb E, Fagerli U, Lund B, et al. Phosphatase of regenerating liver-3 (PRL-3) is overexpressed in classical Hodgkin lymphoma and promotes survival and migration. Exp Hematol Oncol. 2018;7:8 pubmed publisher
	Tzach Nahman R, Nashef R, Fleissig O, Palmon A, Shapira L, Wilensky A, et al. Oral fibroblasts modulate the macrophage response to bacterial challenge. Sci Rep. 2017;7:11516 pubmed publisher
	Brencicova E, Jagger A, Evans H, Georgouli M, Laios A, Attard Montalto S, et al. Interleukin-10 and prostaglandin E2 have complementary but distinct suppressive effects on Toll-like receptor-mediated dendritic cell activation in ovarian carcinoma. PLoS ONE. 2017;12:e0175712 pubmed publisher
	Hoare M, Ito Y, Kang T, Weekes M, Matheson N, Patten D, et al. NOTCH1 mediates a switch between two distinct secretomes during senescence. Nat Cell Biol. 2016;18:979-92 pubmed publisher
	Suwara M, Green N, Borthwick L, Mann J, Mayer Barber K, Barron L, et al. IL-1α released from damaged epithelial cells is sufficient and essential to trigger inflammatory responses in human lung fibroblasts. Mucosal Immunol. 2014;7:684-93 pubmed publisher
	Becker T, Boyd S, Mijatov B, Gowrishankar K, Snoyman S, Pupo G, et al. Mutant B-RAF-Mcl-1 survival signaling depends on the STAT3 transcription factor. Oncogene. 2014;33:1158-66 pubmed publisher
	Nakajima N, Van Tin N, Sato Y, Thach H, Katano H, Diep P, et al. Pathological study of archival lung tissues from five fatal cases of avian H5N1 influenza in Vietnam. Mod Pathol. 2013;26:357-69 pubmed publisher
	Corvaisier M, Delneste Y, Jeanvoine H, Preisser L, Blanchard S, Garo E, et al. IL-26 is overexpressed in rheumatoid arthritis and induces proinflammatory cytokine production and Th17 cell generation. PLoS Biol. 2012;10:e1001395 pubmed publisher
	Steinbicker A, Sachidanandan C, Vonner A, Yusuf R, Deng D, Lai C, et al. Inhibition of bone morphogenetic protein signaling attenuates anemia associated with inflammation. Blood. 2011;117:4915-23 pubmed publisher
	Rodier F, Coppe J, Patil C, Hoeijmakers W, Muñoz D, Raza S, et al. Persistent DNA damage signalling triggers senescence-associated inflammatory cytokine secretion. Nat Cell Biol. 2009;11:973-9 pubmed publisher
	Maneechotesuwan K, Wamanuttajinda V, Kasetsinsombat K, Huabprasert S, Yaikwawong M, Barnes P, et al. Der p 1 suppresses indoleamine 2, 3-dioxygenase in dendritic cells from house dust mite-sensitive patients with asthma. J Allergy Clin Immunol. 2009;123:239-48 pubmed publisher
	Chong D, Boehlke C, Zheng Q, Zhang L, Han Y, Zacks D. Interleukin-6 as a photoreceptor neuroprotectant in an experimental model of retinal detachment. Invest Ophthalmol Vis Sci. 2008;49:3193-200 pubmed publisher
	Ren Y, Lin C, Li Z, Chen X, Huang X, Lui V, et al. Up-regulation of macrophage migration inhibitory factor in infants with acute neonatal necrotizing enterocolitis. Histopathology. 2005;46:659-67 pubmed

product information

brand :

R&D Systems

master code :

MAB2061

SKU :

MAB2061-100

product name :

Human IL-6 Antibody

description :

The Human IL-6 Antibody from R&D Systems is a mouse monoclonal antibody to IL-6. This antibody reacts with human. The Human IL-6 Antibody has been validated for the following applications: Immunohistochemistry, Neutralization, Intracellular Staining by Flow Cytometry, Immunocytochemistry, CyTOF-ready.

target :

IL-6

category :

Primary Antibodies

unit size :

100 ug (also 25 ug, 500 ug)

buffer :

Lyophilized from a 0.2 µm filtered solution in PBS and NaCl with Trehalose. *Small pack size (SP) is supplied as a 0.2 µm filtered solution in PBS.

clonality :

Monoclonal

clone :

1936

concentration :

LYOPH

conjugate :

Unconjugated

host :

Mouse

immunogen :

E. coli -derived recombinant human IL-6, Val30-Met212, Accession # P05231

isotype :

IgG2b

purity :

Protein A or G purified from hybridoma culture supernatant

species :

Human

specificity :

Detects human IL-6 in direct ELISAs. Does not cross-react with recombinant IL-6 from mouse, rat, or pig.

gene symbol :

IL6

details of functionality :

ActivityAssaywCitation not found None None None None

endotoxin note :

<0.20 EU per 1 µg of the antibody by the LAL method.

catalog number base :

MAB2061

accessionNumbers :

P05231

applications :

Immunohistochemistry, Neutralization, Intracellular Staining by Flow Cytometry, Immunocytochemistry, CyTOF-ready

2020 USD :

339

2021 USD :

369 USD

alt names :

B-cell differentiation factor, B-cell stimulatory factor 2, BSF2, BSF-2, CDF, CTL differentiation factor, HGF, HSF, hybridoma growth factor, IFNB2, IFN-beta-2, IL6, IL-6, Interferon beta-2, interleukin 6 (interferon, beta 2), interleukin BSF-2, interleukin-6, MGI-2A

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 6 months, -20 to -70 °C under sterile conditions after reconstitution.