product summary
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company name :
R&D Systems
product type :
antibody
product name :
Human IL-4 Antibody
catalog :
MAB204-100
quantity :
100 ug (also 25 ug, 500 ug)
price :
519 USD
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
34019
reactivity :
human
application :
western blot, neutralization, flow cytometry, blocking or activating experiments
more info or order :
R&D Systems product webpage
citations: 27
Published Application/Species/Sample/DilutionReference
  • blocking or activating experiments; human; loading ...; fig 8a
Wellemans V, Benhassou H, Fuselier E, Bellesort F, Dury S, Lebargy F, et al. Role of CCR3 in respiratory syncytial virus infection of airway epithelial cells. iScience. 2021;24:103433 pubmed publisher
Law C, Wacleche V, Cao Y, Pillai A, Sowerby J, Hancock B, et al. Interferon subverts an AHR-JUN axis to promote CXCL13+ T cells in lupus. Nature. 2024;631:857-866 pubmed publisher
Alzahrani S, Shinwari Z, Gaafar A, Alaiya A, Al Kahtani A. Anti-Inflammatory Effect of Specialized Proresolving Lipid Mediators on Mesenchymal Stem Cells: An In Vitro Study. Cells. 2022;12: pubmed publisher
Magnusson R, Rundquist O, Kim M, Hellberg S, Na C, Benson M, et al. RNA-sequencing and mass-spectrometry proteomic time-series analysis of T-cell differentiation identified multiple splice variants models that predicted validated protein biomarkers in inflammatory diseases. Front Mol Biosci. 2022;9:916128 pubmed publisher
Rode A, Buus T, Mraz V, Al Jaberi F, Lopez D, Ford S, et al. Induced Human Regulatory T Cells Express the Glucagon-like Peptide-1 Receptor. Cells. 2022;11: pubmed publisher
Singhatanadgit W, Kitpakornsanti S, Toso M, Pavasant P. IFNγ-primed periodontal ligament cells regulate T-cell responses via IFNγ-inducible mediators and ICAM-1-mediated direct cell contact. R Soc Open Sci. 2022;9:220056 pubmed publisher
Khan M, Khan M, Kalim U, Khan S, Junttila S, Paulin N, et al. Long Intergenic Noncoding RNA MIAT as a Regulator of Human Th17 Cell Differentiation. Front Immunol. 2022;13:856762 pubmed publisher
Li X, Lee E, Lilja S, Loscalzo J, Sch xe4 fer S, Smelik M, et al. A dynamic single cell-based framework for digital twins to prioritize disease genes and drug targets. Genome Med. 2022;14:48 pubmed publisher
Zenere A, Rundquist O, Gustafsson M, Altafini C. Multi-omics protein-coding units as massively parallel Bayesian networks: Empirical validation of causality structure. iScience. 2022;25:104048 pubmed publisher
Rundquist O, Nestor C, Jenmalm M, Hellberg S, Gustafsson M. Progesterone Inhibits the Establishment of Activation-Associated Chromatin During TH1 Differentiation. Front Immunol. 2022;13:835625 pubmed publisher
Khan M, V xe4 likangas T, Khan M, Moulder R, Ullah U, Bhosale S, et al. Protein interactome of the Cancerous Inhibitor of protein phosphatase 2A (CIP2A) in Th17 cells. Curr Res Immunol. 2020;1:10-22 pubmed publisher
Apaydin D, Jaramillo P, Corradi L, Cosco F, Rathjen F, Kammertoens T, et al. Early-Life Stress Regulates Cardiac Development through an IL-4-Glucocorticoid Signaling Balance. Cell Rep. 2020;33:108404 pubmed publisher
Ma F, Hao H, Gao X, Cai Y, Zhou J, Liang P, et al. Melatonin ameliorates necrotizing enterocolitis by preventing Th17/Treg imbalance through activation of the AMPK/SIRT1 pathway. Theranostics. 2020;10:7730-7746 pubmed publisher
Chong W, Mattapallil M, Raychaudhuri K, Bing S, Wu S, Zhong Y, et al. The Cytokine IL-17A Limits Th17 Pathogenicity via a Negative Feedback Loop Driven by Autocrine Induction of IL-24. Immunity. 2020;53:384-397.e5 pubmed publisher
Inokuchi S, Mitoma H, Kawano S, Nakano S, Ayano M, Kimoto Y, et al. Homeostatic Milieu Induces Production of Deoxyribonuclease 1-like 3 from Myeloid Cells. J Immunol. 2020;204:2088-2097 pubmed publisher
Hartana C, Ahlén Bergman E, Zirakzadeh A, Krantz D, Winerdal M, Winerdal M, et al. Urothelial bladder cancer may suppress perforin expression in CD8+ T cells by an ICAM-1/TGFβ2 mediated pathway. PLoS ONE. 2018;13:e0200079 pubmed publisher
Rode A, Kongsbak M, Hansen M, Lopez D, Levring T, Woetmann A, et al. Vitamin D Counteracts Mycobacterium tuberculosis-Induced Cathelicidin Downregulation in Dendritic Cells and Allows Th1 Differentiation and IFNγ Secretion. Front Immunol. 2017;8:656 pubmed publisher
Longhi M, Vuerich M, Kalbasi A, Kenison J, Yeste A, Csizmadia E, et al. Bilirubin suppresses Th17 immunity in colitis by upregulating CD39. JCI Insight. 2017;2: pubmed publisher
Kongsbak M, von Essen M, Boding L, Levring T, Schjerling P, Lauritsen J, et al. Vitamin D up-regulates the vitamin D receptor by protecting it from proteasomal degradation in human CD4+ T cells. PLoS ONE. 2014;9:e96695 pubmed publisher
van Rompaey L, Galien R, van der Aar E, Clément Lacroix P, Nelles L, Smets B, et al. Preclinical characterization of GLPG0634, a selective inhibitor of JAK1, for the treatment of inflammatory diseases. J Immunol. 2013;191:3568-77 pubmed publisher
Chang H, Han L, Goswami R, Nguyen E, Pelloso D, Robertson M, et al. Impaired development of human Th1 cells in patients with deficient expression of STAT4. Blood. 2009;113:5887-90 pubmed publisher
Dai Z, Turtle C, Booth G, Riddell S, Gooley T, Stevens A, et al. Normally occurring NKG2D+CD4+ T cells are immunosuppressive and inversely correlated with disease activity in juvenile-onset lupus. J Exp Med. 2009;206:793-805 pubmed publisher
Acosta Rodriguez E, Napolitani G, Lanzavecchia A, Sallusto F. Interleukins 1beta and 6 but not transforming growth factor-beta are essential for the differentiation of interleukin 17-producing human T helper cells. Nat Immunol. 2007;8:942-9 pubmed
Ebert E, Mehta V. Human intestinal intraepithelial lymphocytes keep TNF alpha levels low by cell uptake and feedback inhibition of transcription. Cell Immunol. 2006;241:7-13 pubmed
Gounni Abdelilah S, Wellemans V, Agouli M, Guenounou M, Hamid Q, Beck L, et al. Increased expression of Th2-associated chemokines in bullous pemphigoid disease. Role of eosinophils in the production and release of these chemokines. Clin Immunol. 2006;120:220-31 pubmed
Howell M, Gallo R, Boguniewicz M, Jones J, Wong C, Streib J, et al. Cytokine milieu of atopic dermatitis skin subverts the innate immune response to vaccinia virus. Immunity. 2006;24:341-8 pubmed
Wolk K, Kunz S, Asadullah K, Sabat R. Cutting edge: immune cells as sources and targets of the IL-10 family members?. J Immunol. 2002;168:5397-402 pubmed
product information
master code :
MAB204
SKU :
MAB204-100
product name :
Human IL-4 Antibody
unit size :
100 ug (also 25 ug, 500 ug)
description :
The Human IL-4 Antibody from R&D Systems is a mouse monoclonal antibody to IL-4. This antibody reacts with human,zebrafish. The Human IL-4 Antibody has been validated for the following applications: Neutralization,Bioassay,In vivo assay,Blocking,Differentiation,Stimulation,Flow Cytometry,Western Blot,Functional Assay.
target :
IL-4
category :
Primary Antibodies
buffer :
Lyophilized from a 0.2 ╡m filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 ╡m filtered solution in PBS.
clonality :
Monoclonal
clone :
34019
concentration :
LYOPH
conjugate :
Unconjugated
host :
Mouse
immunogen :
E. coli -derived recombinant human IL-4, His25-Ser153, Accession # P05112
isotype :
IgG2b
purity :
Protein A or G purified from hybridoma culture supernatant
species :
Human,Zebrafish
specificity :
Detects human IL-4 in Western blots. In Western blots, no cross-reactivity with recombinant mouse IL-4, recombinant porcine IL-4, recombinant cotton rat IL-4, recombinant rat IL-4, or recombinant human IL-13 is observed.
gene symbol :
IL4
endotoxin note :
<0.10 EU per 1 ╡g of the antibody by the LAL method.
top caption :
Cell Proliferation Induced by IL-4 and Neutralization by Human IL-4 Antibody.
accessionNumbers :
P05112
applications :
Bioassay,Neutralization,Blocking,Differentiation,Stimulation,Flow Cytometry,Western Blot,Functional Assay,In vivo assay
USD :
519 USD
alt names :
B cell growth factor 1, BCDF, B-cell stimulatory factor 1, BCGF1, BCGF-1, binetrakin, BSF1, BSF-1, IL4, IL-4B_cell stimulatory factor 1, IL4E12, interleukin 4, interleukin-4, Lymphocyte stimulatory factor 1, MGC79402, Pitrakinra
storage :
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 6 months, -20 to -70 ░C under sterile conditions after reconstitution.
more info or order :
R&D Systems product webpage
company information
R&D Systems
614 McKinley Place N.E.
Minneapolis, MN 55413
info@RnDSystems.com
https://www.rndsystems.com
800 343-7475
headquarters: USA
R&D Systems develops and manufactures high-quality proteins and serves as a world leader in immunoassays. R&D Systems also produces quality antibodies, antibody arrays, stem cell and cell culture products, and cell selection and detection products, serving the life science and diagnostics industry.