Human Complement Component C5/C5a Antibody | R&D Systems MAB2037-100 product information

product summary

company name :

R&D Systems

product type :

antibody

product name :

Human Complement Component C5/C5a Antibody

catalog :

MAB2037-100

quantity :

100 ug (also 25 ug, 500 ug)

price :

469 USD

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

295003

reactivity :

human

application :

western blot, ELISA, neutralization

more info or order :

R&D Systems product webpage

citations: 9

Reference
Ullgren A, xd6 ijerstedt L, Olofsson J, Bergstr xf6 m S, Remnest xe5 l J, van Swieten J, et al. Altered plasma protein profiles in genetic FTD - a GENFI study. Mol Neurodegener. 2023;18:85 pubmed publisher
Li C, Chen T, Liu J, Wang Y, Zhang C, Guo L, et al. FGF19-Induced Inflammatory CAF Promoted Neutrophil Extracellular Trap Formation in the Liver Metastasis of Colorectal Cancer. Adv Sci (Weinh). 2023;10:e2302613 pubmed publisher
Toy C, Song H, Nagaraja H, Scott J, Greco J, Zhang X, et al. The Influence of an Elastase-Sensitive Complement C5 Variant on Lupus Nephritis and Its Flare. Kidney Int Rep. 2021;6:2105-2113 pubmed publisher
Shah T, Pallera H, Kaszowski C, Bass W, Lattanzio F. Therapeutic Hypothermia Inhibits the Classical Complement Pathway in a Rat Model of Neonatal Hypoxic-Ischemic Encephalopathy. Front Neurosci. 2021;15:616734 pubmed publisher
Ayoub I, Shapiro J, Song H, Zhang X, Parikh S, Almaani S, et al. Establishing a Case for Anti-complement Therapy in Membranous Nephropathy. Kidney Int Rep. 2021;6:484-492 pubmed publisher
Rathi S, Jalali S, Patnaik S, Shahulhameed S, Musada G, Balakrishnan D, et al. Abnormal Complement Activation and Inflammation in the Pathogenesis of Retinopathy of Prematurity. Front Immunol. 2017;8:1868 pubmed publisher
Georgoutsou Spyridonos M, Ricklin D, Pratsinis H, Perivolioti E, Pirmettis I, Garcia B, et al. Attenuation of Staphylococcus aureus-Induced Bacteremia by Human Mini-Antibodies Targeting the Complement Inhibitory Protein Efb. J Immunol. 2015;195:3946-58 pubmed publisher
Ramadass M, Ghebrehiwet B, Smith R, Kew R. Generation of multiple fluid-phase C3b:plasma protein complexes during complement activation: possible implications in C3 glomerulopathies. J Immunol. 2014;192:1220-30 pubmed publisher
Kambas K, Markiewski M, Pneumatikos I, Rafail S, Theodorou V, Konstantonis D, et al. C5a and TNF-alpha up-regulate the expression of tissue factor in intra-alveolar neutrophils of patients with the acute respiratory distress syndrome. J Immunol. 2008;180:7368-75 pubmed

product information

master code :

MAB2037

SKU :

MAB2037-100

product name :

Human Complement Component C5/C5a Antibody

unit size :

100 ug (also 25 ug, 500 ug)

description :

The Human Complement Component C5/C5a Antibody from R&D Systems is a mouse monoclonal antibody to Complement Component C5/C5a. This antibody reacts with human,rat. The Human Complement Component C5/C5a Antibody has been validated for the following applications: Neutralization,Western Blot,Bioassay,ELISA Development,ELISA Development (Capture),ELISA Capture,ELISA Capture (Matched Antibody Pair).

target :

Complement Component C5/C5a

category :

Primary Antibodies

buffer :

Lyophilized from a 0.2 ╡m filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 ╡m filtered solution in PBS.

clonality :

Monoclonal

clone :

295003

concentration :

LYOPH

conjugate :

Unconjugated

host :

Mouse

immunogen :

E. coli -derived recombinant human Complement Component C5a, Thr678-Arg751, Accession # P01031

isotype :

IgG1

purity :

Protein A or G purified from hybridoma culture supernatant

species :

Human,Rat

specificity :

Detects human Complement Component C5/C5a in ELISAs and Western blots. In sandwich immunoassays, detects human Complement Component C5a by itself or in the context of Complement Component C5. In Western blots, this antibody does not cross-react with recombinant human Complement Component C2, recombinant mouse (rm) Complement Component C3d, or rmComplement Component C5a.

gene symbol :

endotoxin note :

<0.10 EU per 1 ╡g of the antibody by the LAL method.

top caption :

N-Acetyl-ss-D-Glucosamini-dase Release Induced by Complement Component C5a and Neutralization by Human Complement Component C5a Antibody.

accessionNumbers :

P01031

applications :

Western Blot,Bioassay,ELISA Development,ELISA Development (Capture),ELISA Capture,Neutralization,ELISA Capture (Matched Antibody Pair)

USD :

469 USD

alt names :

C5, C5a;C5b;C5D;Complement C5;CPAMD4;ECLZB

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 6 months, -20 to -70 ░C under sterile conditions after reconstitution.

more info or order :

R&D Systems product webpage