product summary
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company name :
R&D Systems
product type :
antibody
product name :
Smad7 Antibody
catalog :
MAB2029
quantity :
100 ug (also 25 ug)
price :
469 USD
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
293039
reactivity :
human, mouse, rat, zebrafish
application :
western blot, immunohistochemistry
more info or order :
citations: 41
Published Application/Species/Sample/DilutionReference
  • western blot; human; 1:1000; loading ...; fig 5f
Wang Y, Xu Z, Wang X, Zheng J, Peng L, Zhou Y, et al. Extracellular-vesicle containing miRNA-503-5p released by macrophages contributes to atherosclerosis. Aging (Albany NY). 2021;13:12239-12257 pubmed publisher
  • immunohistochemistry; human; loading ...; fig 8c
  • western blot; zebrafish ; 1:1000; loading ...; fig 5c
Lai C, Yeh K, Lin C, Hsieh Y, Lai H, Chen J, et al. MicroRNA-21 Plays Multiple Oncometabolic Roles in the Process of NAFLD-Related Hepatocellular Carcinoma via PI3K/AKT, TGF-β, and STAT3 Signaling. Cancers (Basel). 2021;13: pubmed publisher
Salemi S, Schori L, Gerwinn T, Horst M, Eberli D. Myostatin Overexpression and Smad Pathway in Detrusor Derived from Pediatric Patients with End-Stage Lower Urinary Tract Dysfunction. Int J Mol Sci. 2023;24: pubmed publisher
Maresca C, Di Maggio G, Stolfi C, Laudisi F, Colella M, Pacifico T, et al. Smad7 Sustains Stat3 Expression and Signaling in Colon Cancer Cells. Cancers (Basel). 2022;14: pubmed publisher
Han S, Ballinger E, Choung S, Kwon J. Anti-Photoaging Effect of Hydrolysates from Pacific Whiting Skin via MAPK/AP-1, NF-κB, TGF-β/Smad, and Nrf-2/HO-1 Signaling Pathway in UVB-Induced Human Dermal Fibroblasts. Mar Drugs. 2022;20: pubmed publisher
Zhang L, Qu J, Qi Y, Duan Y, Huang Y, Zhou Z, et al. EZH2 engages TGFβ signaling to promote breast cancer bone metastasis via integrin β1-FAK activation. Nat Commun. 2022;13:2543 pubmed publisher
Wu W, Huang X, You Y, Xue L, Wang X, Meng X, et al. Latent TGF-β1 protects against diabetic kidney disease via Arkadia/Smad7 signaling. Int J Biol Sci. 2021;17:3583-3594 pubmed publisher
Wu T, Li X, Jia X, Zhu Z, Lu J, Feng H, et al. Krüppel like factor 10 prevents intervertebral disc degeneration via TGF-β signaling pathway both in vitro and in vivo. J Orthop Translat. 2021;29:19-29 pubmed publisher
Niu B, Liu J, Lv B, Lin J, Li X, Wu C, et al. Interplay between transforming growth factor-β and Nur77 in dual regulations of inhibitor of differentiation 1 for colonic tumorigenesis. Nat Commun. 2021;12:2809 pubmed publisher
He S, Sun S, Lu J, Chen L, Mei X, Li L, et al. The effects of the miR-21/SMAD7/TGF-β pathway on Th17 cell differentiation in COPD. Sci Rep. 2021;11:6338 pubmed publisher
Gao Q, Huang Q, Li F, Luo F. LncRNA MCTP1-AS1 Regulates EMT Process in Endometrial Cancer by Targeting the miR-650/SMAD7 Axis. Onco Targets Ther. 2021;14:751-761 pubmed publisher
Yuan F, Yin H, Deng Y, Jiao F, Jiang H, Niu Y, et al. Overexpression of Smad7 in hypothalamic POMC neurons disrupts glucose balance by attenuating central insulin signaling. Mol Metab. 2020;42:101084 pubmed publisher
Han Y, Yoon Y, Go G, Lee J, Lee S. Melatonin Protects Human Renal Proximal Tubule Epithelial Cells Against High Glucose-Mediated Fibrosis via the Cellular Prion Protein-TGF-β-Smad Signaling Axis. Int J Med Sci. 2020;17:1235-1245 pubmed publisher
Ungefroren H, Kumarasinghe A, Musfeldt M, Fiedler C, Lehnert H, Marquardt J. RAC1B Induces SMAD7 via USP26 to Suppress TGFβ1-Dependent Cell Migration in Mesenchymal-Subtype Carcinoma Cells. Cancers (Basel). 2020;12: pubmed publisher
Halder L, Jo E, Hasan M, Ferreira Gomes M, Krüger T, Westermann M, et al. Immune modulation by complement receptor 3-dependent human monocyte TGF-β1-transporting vesicles. Nat Commun. 2020;11:2331 pubmed publisher
Tufa D, Shank T, Yingst A, Trahan G, Shim S, Lake J, et al. Prolactin Acts on Myeloid Progenitors to Modulate SMAD7 Expression and Enhance Hematopoietic Stem Cell Differentiation into the NK Cell Lineage. Sci Rep. 2020;10:6335 pubmed publisher
Di Filippo E, Costamagna D, Giacomazzi G, Cortés Calabuig Á, Stryjewska A, Huylebroeck D, et al. Zeb2 Regulates Myogenic Differentiation in Pluripotent Stem Cells. Int J Mol Sci. 2020;21: pubmed publisher
Barbosa D, Fahlbusch P, Herzfeld de Wiza D, Jacob S, Kettel U, Al Hasani H, et al. Rhein, a novel Histone Deacetylase (HDAC) inhibitor with antifibrotic potency in human myocardial fibrosis. Sci Rep. 2020;10:4888 pubmed publisher
Gu W, Hong X, Le Bras A, Nowak W, Issa Bhaloo S, Deng J, et al. Smooth muscle cells differentiated from mesenchymal stem cells are regulated by microRNAs and suitable for vascular tissue grafts. J Biol Chem. 2018;293:8089-8102 pubmed publisher
Huang X, Yue Z, Wu J, Chen J, Wang S, Wu J, et al. MicroRNA-21 Knockout Exacerbates Angiotensin II-Induced Thoracic Aortic Aneurysm and Dissection in Mice With Abnormal Transforming Growth Factor-β-SMAD3 Signaling. Arterioscler Thromb Vasc Biol. 2018;38:1086-1101 pubmed publisher
Wang X, Zhao Y, Sun L, Shi Y, Li Z, Zhao X, et al. Exosomes derived from human umbilical cord mesenchymal stem cells improve myocardial repair via upregulation of Smad7. Int J Mol Med. 2018;41:3063-3072 pubmed publisher
Syed S, Dinallo V, Iqbal N, Di Iorio L, Di Fusco D, Guleria S, et al. High SMAD7 and p-SMAD2,3 expression is associated with environmental enteropathy in children. PLoS Negl Trop Dis. 2018;12:e0006224 pubmed publisher
De Simone V, Bevivino G, Sedda S, Izzo R, Laudisi F, Dinallo V, et al. Smad7 knockdown activates protein kinase RNA-associated eIF2α pathway leading to colon cancer cell death. Cell Death Dis. 2017;8:e2681 pubmed publisher
Sun H, Peng Z, Tang H, Xie D, Jia Z, Zhong L, et al. Loss of KLF4 and consequential downregulation of Smad7 exacerbate oncogenic TGF-? signaling in and promote progression of hepatocellular carcinoma. Oncogene. 2017;36:2957-2968 pubmed publisher
Feng T, Dzieran J, Yuan X, Dropmann A, Maass T, Teufel A, et al. Hepatocyte-specific Smad7 deletion accelerates DEN-induced HCC via activation of STAT3 signaling in mice. Oncogenesis. 2017;6:e294 pubmed publisher
Wu X, Wu X, Ma Y, Shao F, Tan Y, Tan T, et al. CUG-binding protein 1 regulates HSC activation and liver fibrogenesis. Nat Commun. 2016;7:13498 pubmed publisher
Li C, Talele N, Boo S, Koehler A, Knee Walden E, Balestrini J, et al. MicroRNA-21 preserves the fibrotic mechanical memory of mesenchymal stem cells. Nat Mater. 2017;16:379-389 pubmed publisher
Tjomsland V, Sandnes D, Pomianowska E, Cizmovic S, Aasrum M, Brusevold I, et al. The TGFβ-SMAD3 pathway inhibits IL-1α induced interactions between human pancreatic stellate cells and pancreatic carcinoma cells and restricts cancer cell migration. J Exp Clin Cancer Res. 2016;35:122 pubmed publisher
Correa L, Zheng Y, Delaney A, Khan Z, Shenoy C, Daftary G. TGF-? Induces Endometriotic Progression via a Noncanonical, KLF11-Mediated Mechanism. Endocrinology. 2016;157:3332-43 pubmed publisher
Marwitz S, Depner S, Dvornikov D, Merkle R, Szczygieł M, Muller Decker K, et al. Downregulation of the TGF? Pseudoreceptor BAMBI in Non-Small Cell Lung Cancer Enhances TGF? Signaling and Invasion. Cancer Res. 2016;76:3785-801 pubmed publisher
Bardita C, Predescu D, Sha F, Patel M, Balaji G, Predescu S. Endocytic deficiency induced by ITSN-1s knockdown alters the Smad2/3-Erk1/2 signaling balance downstream of Alk5. J Cell Sci. 2015;128:1528-41 pubmed publisher
Murugaiyan G, da Cunha A, Ajay A, Joller N, Garo L, Kumaradevan S, et al. MicroRNA-21 promotes Th17 differentiation and mediates experimental autoimmune encephalomyelitis. J Clin Invest. 2015;125:1069-80 pubmed publisher
Lu G, Xu S, Peng L, Huang Z, Wang Y, Gao X. Angiotensin II upregulates Kv1.5 expression through ROS-dependent transforming growth factor-beta1 and extracellular signal-regulated kinase 1/2 signalings in neonatal rat atrial myocytes. Biochem Biophys Res Commun. 2014;454:410-6 pubmed publisher
Mehuron T, Kumar A, Duarte L, Yamauchi J, Accorsi A, Girgenrath M. Dysregulation of matricellular proteins is an early signature of pathology in laminin-deficient muscular dystrophy. Skelet Muscle. 2014;4:14 pubmed publisher
Parikh A, Lee C, Joseph P, Marchini S, Baccarini A, Kolev V, et al. microRNA-181a has a critical role in ovarian cancer progression through the regulation of the epithelial-mesenchymal transition. Nat Commun. 2014;5:2977 pubmed publisher
Devine D, Rostas J, Metge B, Das S, Mulekar M, Tucker J, et al. Loss of N-Myc interactor promotes epithelial-mesenchymal transition by activation of TGF-?/SMAD signaling. Oncogene. 2014;33:2620-8 pubmed publisher
Wang M, Hada M, Saha J, Sridharan D, Pluth J, Cucinotta F. Protons sensitize epithelial cells to mesenchymal transition. PLoS ONE. 2012;7:e41249 pubmed publisher
Hneino M, François A, Buard V, Tarlet G, Abderrahmani R, Blirando K, et al. The TGF-β/Smad repressor TG-interacting factor 1 (TGIF1) plays a role in radiation-induced intestinal injury independently of a Smad signaling pathway. PLoS ONE. 2012;7:e35672 pubmed publisher
Su R, Lei W, Liu J, Zhang Z, Jia B, Feng X, et al. The integrative analysis of microRNA and mRNA expression in mouse uterus under delayed implantation and activation. PLoS ONE. 2010;5:e15513 pubmed publisher
Miyake T, Alli N, McDermott J. Nuclear function of Smad7 promotes myogenesis. Mol Cell Biol. 2010;30:722-35 pubmed publisher
Seong H, Jung H, Kim K, Ha H. 3-Phosphoinositide-dependent PDK1 negatively regulates transforming growth factor-beta-induced signaling in a kinase-dependent manner through physical interaction with Smad proteins. J Biol Chem. 2007;282:12272-89 pubmed
image
image 1 :
R&D Systems MAB2029 image 1
Smad7 antibody in Human Liver Cancer Tissue by Immunohistochemistry (IHC-P).
product information
brand :
R&D Systems, a Bio-Techne Brand
catalog number base :
MAB2029
SKU :
MAB2029
product name :
Smad7 Antibody
Description :
The Human/Mouse/Rat Smad7 Antibody from R&D Systems is a mouse monoclonal antibody to Smad7. This antibody reacts with human, mouse, rat. The Human/Mouse/Rat Smad7 Antibody has been validated for the following applications: Western Blot, Simple Western, Immunohistochemistry.
target :
Smad7
category :
Primary Antibodies
unit size :
100 ug (also 25 ug)
buffer :
Lyophilized from a 0.2 µm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.
clonality :
Monoclonal
clone :
293039
concentration :
LYOPH
conjugate :
Unconjugated
host :
Mouse
immunogen :
E. coli -derived recombinant human Smad7, Gly320-Ser398, Accession # O15105
isotype :
IgG2b
purity :
Protein A or G purified from hybridoma culture supernatant
species :
Human, Mouse, Rat
specificity :
Detects human, mouse, and rat Smad7.
gene symbol :
SMAD7
accessionNumbers :
O15105
applications :
Western Blot, Simple Western, Immunohistochemistry
USD :
469 USD
alt names :
CRCS3, FLJ16482, hSMAD7, MAD homolog 7, MAD homolog 8, MAD, mothers against decapentaplegic homolog 7 (Drosophila), MADH7, MADH7mothers against decapentaplegic homolog 7, MADH8, Mothers against decapentaplegic homolog 8, Mothers against decapentaplegic, drosophila, homolog of, 7, Mothers against DPP homolog 7, Mothers against DPP homolog 8, SMAD 7, SMAD family member 7MAD (mothers against decapentaplegic, Drosophila) homolog 7, SMAD, mothers against DPP homolog 7, SMAD, mothers against DPP homolog 7 (Drosophila), Smad7
storage :
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 6 months, -20 to -70 °C under sterile conditions after reconstitution.
more info or order :
company information
R&D Systems
614 McKinley Place N.E.
Minneapolis, MN 55413
info@RnDSystems.com
https://www.rndsystems.com
800 343-7475
headquarters: USA
R&D Systems develops and manufactures high-quality proteins and serves as a world leader in immunoassays. R&D Systems also produces quality antibodies, antibody arrays, stem cell and cell culture products, and cell selection and detection products, serving the life science and diagnostics industry.