IL-2 Antibody | R&D Systems MAB202-100 product information

product summary

company name :

R&D Systems

product type :

antibody

product name :

IL-2 Antibody

catalog :

MAB202-100

quantity :

100 ug (also 25 ug, 500 ug)

price :

453 USD

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

5334

reactivity :

human

application :

immunocytochemistry, neutralization

more info or order :

R&D Systems product webpage

citations: 17

Reference
Ukita M, Hamanishi J, Yoshitomi H, Yamanoi K, Takamatsu S, Ueda A, et al. CXCL13-producing CD4+ T cells accumulate in the early phase of tertiary lymphoid structures in ovarian cancer. JCI Insight. 2022;7: pubmed publisher
Rodr xed guez xc1 lvarez Y, Batista Roche L, Llópiz Arzuaga A, Puente P xe9 rez P, Mart xed nez Castillo R, Castro Velazco J, et al. Immunogenicity profile in African green monkeys of a vaccine candidate based on a mutated form of human Interleukin-15. BMC Immunol. 2021;22:79 pubmed publisher
Sahin D, Arenas Ramirez N, Rath M, Karakus U, Hümbelin M, van Gogh M, et al. An IL-2-grafted antibody immunotherapy with potent efficacy against metastatic cancer. Nat Commun. 2020;11:6440 pubmed publisher
Güler A, Lopez Venegas M, Adankwah E, Mayatepek E, Nausch N, Jacobsen M. Suppressor of cytokine signalling 3 is crucial for interleukin-7 receptor re-expression after T-cell activation and interleukin-7 dependent proliferation. Eur J Immunol. 2020;50:234-244 pubmed publisher
Kim J, Jang S, Yun J, Jung M, Woo S. Effects of pepsin and pepstatin on reflux tonsil hypertrophy in vitro. PLoS ONE. 2018;13:e0207090 pubmed publisher
Carmenate T, Ortiz Y, Enamorado M, García Martínez K, Avellanet J, Moreno E, et al. Blocking IL-2 Signal In Vivo with an IL-2 Antagonist Reduces Tumor Growth through the Control of Regulatory T Cells. J Immunol. 2018;200:3475-3484 pubmed publisher
Revu S, Wu J, Henkel M, Rittenhouse N, Menk A, Delgoffe G, et al. IL-23 and IL-1β Drive Human Th17 Cell Differentiation and Metabolic Reprogramming in Absence of CD28 Costimulation. Cell Rep. 2018;22:2642-2653 pubmed publisher
Jiang J, Chen X, An H, Yang B, Zhang F, Cheng X. Enhanced immune response of MAIT cells in tuberculous pleural effusions depends on cytokine signaling. Sci Rep. 2016;6:32320 pubmed publisher
Locci M, Wu J, Arumemi F, Mikulski Z, Dahlberg C, Miller A, et al. Activin A programs the differentiation of human TFH cells. Nat Immunol. 2016;17:976-84 pubmed publisher
Nata T, Basheer A, Cocchi F, van Besien R, Massoud R, Jacobson S, et al. Targeting the binding interface on a shared receptor subunit of a cytokine family enables the inhibition of multiple member cytokines with selectable target spectrum. J Biol Chem. 2015;290:22338-51 pubmed publisher
Kim D, Zloza A, Broucek J, Schenkel J, Ruby C, Samaha G, et al. Interleukin-2 alters distribution of CD144 (VE-cadherin) in endothelial cells. J Transl Med. 2014;12:113 pubmed publisher
Weissmüller S, Semmler L, Kalinke U, Christians S, Muller Berghaus J, Waibler Z. ICOS-LICOS interaction is critically involved in TGN1412-mediated T-cell activation. Blood. 2012;119:6268-77 pubmed publisher
Hutnick N, Carnathan D, Demers K, Makedonas G, Ertl H, Betts M. Adenovirus-specific human T cells are pervasive, polyfunctional, and cross-reactive. Vaccine. 2010;28:1932-41 pubmed publisher
Withers D, Fiorini C, Fischer R, Ettinger R, Lipsky P, Grammer A. T cell-dependent survival of CD20+ and CD20- plasma cells in human secondary lymphoid tissue. Blood. 2007;109:4856-64 pubmed
Karenko L, Hahtola S, Päivinen S, Karhu R, Syrjä S, Kähkönen M, et al. Primary cutaneous T-cell lymphomas show a deletion or translocation affecting NAV3, the human UNC-53 homologue. Cancer Res. 2005;65:8101-10 pubmed
Sen Y, Chunsong H, Baojun H, Linjie Z, Qun L, San J, et al. Aberration of CCR7 CD8 memory T cells from patients with systemic lupus erythematosus: an inducer of T helper type 2 bias of CD4 T cells. Immunology. 2004;112:274-89 pubmed
Herrero C, Hu X, Li W, Samuels S, Sharif M, Kotenko S, et al. Reprogramming of IL-10 activity and signaling by IFN-gamma. J Immunol. 2003;171:5034-41 pubmed

image

image 1 :

Cell Proliferation Induced by IL-2 and Neutralization by Human IL-2 Antibody.

product information

brand :

R&D Systems

master code :

MAB202

SKU :

MAB202-100

product name :

IL-2 Antibody

description :

The Human IL-2 Antibody from R&D Systems is a mouse monoclonal antibody to IL-2. This antibody reacts with human. The Human IL-2 Antibody has been validated for the following applications: Neutralization, Intracellular Staining by Flow Cytometry, Immunocytochemistry, CyTOF-ready.

target :

IL-2

category :

Primary Antibodies

unit sizes :

100 ug (also 25 ug, 500 ug)

buffer :

Lyophilized from a 0.2 µm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.

clonality :

Monoclonal

clone :

5334

concentration :

LYOPH

conjugate :

Unconjugated

host :

Mouse

immunogen :

E. coli -derived recombinant human IL-2, Ala21-Thr153, Accession # NP_000577

isotype :

IgG1

purity :

Protein A or G purified from hybridoma culture supernatant

species :

Human

specificity :

Detects human IL-2 in direct ELISAs. Does not cross-react with recombinant IL-2 from mouse, rat, pig, or cotton rat.

gene symbol :

IL2

endotoxin note :

<0.10 EU per 1 µg of the antibody by the LAL method.

accessionNumbers :

NP_000577

applications :

Neutralization, Intracellular Staining by Flow Cytometry, Immunocytochemistry, CyTOF-ready

USD :

453 USD

alt names :

aldesleukin, IL2, IL-2, IL-2lymphokine, interleukin 2, interleukin-2, involved in regulation of T-cell clonal expansion, Proleukin, T cell growth factor, T-cell growth factor, TCGF

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 6 months, -20 to -70 °C under sterile conditions after reconstitution.

more info or order :

R&D Systems product webpage