Human S1P1/EDG-1 Antibody | R&D Systems MAB2016-100 product information

product summary

company name :

R&D Systems

product type :

antibody

product name :

Human S1P1/EDG-1 Antibody

catalog :

MAB2016-100

quantity :

100 ug (also 25 ug, 500 ug)

price :

479 USD

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

218713

reactivity :

human, rat

application :

western blot, flow cytometry

more info or order :

R&D Systems product webpage

citations: 11

Reference
Nakamura S, Yamamoto R, Matsuda T, Yasuda H, Nishinaka A, Takahashi K, et al. Sphingosine-1-phosphate receptor 1/5 selective agonist alleviates ocular vascular pathologies. Sci Rep. 2024;14:9700 pubmed publisher
Johansen V, Hampson E, Tsonou E, Pantarelli C, Chu J, Crossland L, et al. The GPCR adaptor protein Norbin regulates S1PR1 trafficking and the morphology, cell cycle and survival of PC12 cells. Sci Rep. 2023;13:18237 pubmed publisher
Syu G, Wang S, Ma G, Liu S, Pearce D, Prakash A, et al. Development and application of a high-content virion display human GPCR array. Nat Commun. 2019;10:1997 pubmed publisher
Linder B, Wehle A, Hehlgans S, Bonn F, Dikic I, Rodel F, et al. Arsenic Trioxide and (-)-Gossypol Synergistically Target Glioma Stem-Like Cells via Inhibition of Hedgehog and Notch Signaling. Cancers (Basel). 2019;11: pubmed publisher
Yamamoto R, Aoki T, Koseki H, Fukuda M, Hirose J, Tsuji K, et al. A sphingosine-1-phosphate receptor type 1 agonist, ASP4058, suppresses intracranial aneurysm through promoting endothelial integrity and blocking macrophage transmigration. Br J Pharmacol. 2017;174:2085-2101 pubmed publisher
Williams P, Stilhano R, To V, Tran L, Wong K, Silva E. Hypoxia augments outgrowth endothelial cell (OEC) sprouting and directed migration in response to sphingosine-1-phosphate (S1P). PLoS ONE. 2015;10:e0123437 pubmed publisher
Till K, Pettitt A, Slupsky J. Expression of functional sphingosine-1 phosphate receptor-1 is reduced by B cell receptor signaling and increased by inhibition of PI3 kinase Î´ but not SYK or BTK in chronic lymphocytic leukemia cells. J Immunol. 2015;194:2439-46 pubmed publisher
Gatfield J, Monnier L, Studer R, Bolli M, Steiner B, Nayler O. Sphingosine-1-phosphate (S1P) displays sustained S1P1 receptor agonism and signaling through S1P lyase-dependent receptor recycling. Cell Signal. 2014;26:1576-88 pubmed publisher
Cabezón R, Sintes J, Llinàs L, Benitez Ribas D. Analysis of HLDA9 mAbs on plasmacytoid dendritic cells. Immunol Lett. 2011;134:167-73 pubmed publisher
Matesanz Isabel J, Sintes J, Llinàs L, de Salort J, Lázaro A, Engel P. New B-cell CD molecules. Immunol Lett. 2011;134:104-12 pubmed publisher
Lorquet S, Berndt S, Blacher S, Gengoux E, Peulen O, Maquoi E, et al. Soluble forms of VEGF receptor-1 and -2 promote vascular maturation via mural cell recruitment. FASEB J. 2010;24:3782-95 pubmed publisher

product information

master code :

MAB2016

SKU :

MAB2016-100

product name :

Human S1P1/EDG-1 Antibody

unit size :

100 ug (also 25 ug, 500 ug)

description :

The Human S1P1/EDG-1 Antibody from R&D Systems is a mouse monoclonal antibody to S1P1/EDG-1. This antibody reacts with human,rat. The Human S1P1/EDG-1 Antibody has been validated for the following applications: Flow Cytometry,Western Blot,CyTOF-ready.

target :

S1P1/EDG-1

category :

Primary Antibodies

buffer :

Lyophilized from a 0.2 ╡m filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 ╡m filtered solution in PBS.

clonality :

Monoclonal

clone :

218713

concentration :

LYOPH

conjugate :

Unconjugated

host :

Mouse

immunogen :

NS0 mouse myeloma cell line transfected with human S1P1/EDG-1, Met1-Ser382, Accession # P21453

isotype :

IgG2b

purity :

Protein A or G purified from hybridoma culture supernatant

species :

Human,Rat

specificity :

Detects human S1P1/EDG-1 by flow cytometry.

gene symbol :

S1PR1

top caption :

Detection of S1P1/EDG-1 antibody in CHO Chinese Hamster Cell Line Transfected with Human S1P1/EDG-1 and eGFP antibody by Flow Cytometry.

accessionNumbers :

P21453

applications :

Flow Cytometry,Western Blot,CyTOF-ready

extended description :

Clone 218713 was used by HLDA to establish CD designation

USD :

479 USD

product details :

Clone 218713 was used by HLDA to establish CD designation

alt names :

CD363, CD363 antigen, CHEDG1, D1S3362, EDG1, EDG-1, EDG1edg-1, Endothelial differentiation G-protein coupled receptor 1, endothelial differentiation, sphingolipid G-protein-coupled receptor, 1, FLJ58121, S1P receptor 1, S1P receptor Edg-1, s1p1, S1P1ECGF1, S1PR1, sphingosine 1-phosphate receptor 1, sphingosine 1-phosphate receptor EDG1, Sphingosine 1-phosphate receptor Edg-1, sphingosine-1-phosphate receptor 1

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 6 months, -20 to -70 ░C under sterile conditions after reconstitution.

more info or order :

R&D Systems product webpage