product summary
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company name :
R&D Systems
product type :
antibody
product name :
Human Kallikrein 6/Neurosin Antibody
catalog :
MAB2008
quantity :
100 ug (also 25 ug)
price :
439 USD
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
265508
reactivity :
human, mouse
application :
western blot, neutralization, immunoprecipitation
more info or order :
R&D Systems product webpage
citations: 4
Reference
Spencer B, Valera E, Rockenstein E, Trejo Morales M, Adame A, Masliah E. A brain-targeted, modified neurosin (kallikrein-6) reduces α-synuclein accumulation in a mouse model of multiple system atrophy. Mol Neurodegener. 2015;10:48 pubmed publisher
Wennström M, Surova Y, Hall S, Nilsson C, Minthon L, Bostrom F, et al. Low CSF levels of both ?-synuclein and the ?-synuclein cleaving enzyme neurosin in patients with synucleinopathy. PLoS ONE. 2013;8:e53250 pubmed publisher
Spencer B, Michael S, Shen J, Kosberg K, Rockenstein E, Patrick C, et al. Lentivirus mediated delivery of neurosin promotes clearance of wild-type ?-synuclein and reduces the pathology in an ?-synuclein model of LBD. Mol Ther. 2013;21:31-41 pubmed publisher
Bin L, Kim B, Hall C, Leach S, Leung D. Inhibition of transcription factor specificity protein 1 alters the gene expression profile of keratinocytes leading to upregulation of kallikrein-related peptidases and thymic stromal lymphopoietin. J Invest Dermatol. 2011;131:2213-22 pubmed publisher
product information
master code :
MAB2008
SKU :
MAB2008
product name :
Human Kallikrein 6/Neurosin Antibody
unit size :
100 ug (also 25 ug)
description :
The Human Kallikrein 6/Neurosin Antibody from R&D Systems is a mouse monoclonal antibody to Kallikrein 6/Neurosin. This antibody reacts with human,mouse. The Human Kallikrein 6/Neurosin Antibody has been validated for the following applications: ELISA Development,Western Blot,Neutralization,Immunoprecipitation.
target :
Kallikrein 6/Neurosin
category :
Primary Antibodies
buffer :
Lyophilized from a 0.2 ╡m filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 ╡m filtered solution in PBS.
clonality :
Monoclonal
clone :
265508
concentration :
LYOPH
conjugate :
Unconjugated
host :
Mouse
immunogen :
Mouse myeloma cell line NS0-derived recombinant human Kallikrein 6/Neurosin, Leu22-Lys244, Accession # Q92876
isotype :
IgG2a
purity :
Protein A or G purified from hybridoma culture supernatant
species :
Human,Mouse
specificity :
Detects human Kallikrein 6/Neurosin in direct ELISAs and Western blots. In Western blots, no cross-reactivity with recombinant human (rh) Factor X, recombinant mouse HGFA, rhKLK3, 4, 5, 8, 10, 11, 15, rhThrombin, or rhuPA is observed.
gene symbol :
KLK6
accessionNumbers :
Q92876
applications :
ELISA Development,Western Blot,Neutralization,Immunoprecipitation
USD :
439 USD
alt names :
Bssp, EC 3.4.21, EC 3.4.21.-, hK6, kallikrein 6 (neurosin, zyme), kallikrein-6, kallikrein-related peptidase 6, KLK6, Klk7, neurosin, Protease M, protease, serine, 18, PRSS18, PRSS9, PRSS9MGC9355, Serine protease 18, Serine protease 9, SP59, Zyme
storage :
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 6 months, -20 to -70 ░C under sterile conditions after reconstitution.
more info or order :
R&D Systems product webpage
company information
R&D Systems
614 McKinley Place N.E.
Minneapolis, MN 55413
info@RnDSystems.com
https://www.rndsystems.com
800 343-7475
headquarters: USA
R&D Systems develops and manufactures high-quality proteins and serves as a world leader in immunoassays. R&D Systems also produces quality antibodies, antibody arrays, stem cell and cell culture products, and cell selection and detection products, serving the life science and diagnostics industry.