Human IL-1 alpha/IL-1F1 Antibody | R&D Systems MAB200 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

R&D Systems

product type :

antibody

product name :

Human IL-1 alpha/IL-1F1 Antibody

catalog :

MAB200

quantity :

100 ug (also 25 ug, 500 ug)

price :

369 USD

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

4414

reactivity :

human

application :

western blot, ELISA, immunocytochemistry, neutralization, blocking or activating experiments

citations: 21

Published Application/Species/Sample/Dilution	Reference
ELISA; human; loading ...; tbl s7	Bouhaddou M, Memon D, Meyer B, White K, Rezelj V, Correa Marrero M, et al. The Global Phosphorylation Landscape of SARS-CoV-2 Infection. Cell. 2020;182:685-712.e19 pubmed publisher
immunocytochemistry; human; loading ...; fig 5f	Pantazi A, Quintanilla A, Hari P, Tarrats N, Parasyraki E, Dix F, et al. Inhibition of the 60S ribosome biogenesis GTPase LSG1 causes endoplasmic reticular disruption and cellular senescence. Aging Cell. 2019;18:e12981 pubmed publisher
blocking or activating experiments; human; loading ...; fig 3c	Bucher H, Mang S, Keck M, Przibilla M, Lamb D, Schiele F, et al. Neutralization of both IL-1α/IL-1β plays a major role in suppressing combined cigarette smoke/virus-induced pulmonary inflammation in mice. Pulm Pharmacol Ther. 2017;44:96-105 pubmed publisher
	Hari P, Millar F, Tarrats N, Birch J, Quintanilla A, Rink C, et al. The innate immune sensor Toll-like receptor 2 controls the senescence-associated secretory phenotype. Sci Adv. 2019;5:eaaw0254 pubmed publisher
	Henry C, Martin S. Caspase-8 Acts in a Non-enzymatic Role as a Scaffold for Assembly of a Pro-inflammatory "FADDosome" Complex upon TRAIL Stimulation. Mol Cell. 2017;65:715-729.e5 pubmed publisher
	Beltrami Moreira M, Vromman A, Sukhova G, Folco E, Libby P. Redundancy of IL-1 Isoform Signaling and Its Implications for Arterial Remodeling. PLoS ONE. 2016;11:e0152474 pubmed publisher
	McCarthy D, Clark R, Bartling T, Trebak M, Melendez J. Redox control of the senescence regulator interleukin-1? and the secretory phenotype. J Biol Chem. 2013;288:32149-59 pubmed publisher
	Bellini A, Marini M, Bianchetti L, Barczyk M, Schmidt M, Mattoli S. Interleukin (IL)-4, IL-13, and IL-17A differentially affect the profibrotic and proinflammatory functions of fibrocytes from asthmatic patients. Mucosal Immunol. 2012;5:140-9 pubmed publisher
	Zepp J, Nold Petry C, Dinarello C, Nold M. Protection from RNA and DNA viruses by IL-32. J Immunol. 2011;186:4110-8 pubmed publisher
	Jung D, Che Z, Kim J, Kim K, Kim K, Williams D, et al. Tumor-stromal crosstalk in invasion of oral squamous cell carcinoma: a pivotal role of CCL7. Int J Cancer. 2010;127:332-44 pubmed publisher
	Wu W, Mehta H, Chakrabarty K, Booth J, Duggan E, Patel K, et al. Resistance of human alveolar macrophages to Bacillus anthracis lethal toxin. J Immunol. 2009;183:5799-806 pubmed publisher
	Chang S, Su P, Lee T. Ectopic expression of interleukin-1 receptor type II enhances cell migration through activation of the pre-interleukin 1alpha pathway. Cytokine. 2009;45:32-8 pubmed publisher
	Nold M, Nold Petry C, Pott G, Zepp J, Saavedra M, Kim S, et al. Endogenous IL-32 controls cytokine and HIV-1 production. J Immunol. 2008;181:557-65 pubmed
	Gonzalez R, Seurynck Servoss S, Crowley S, Brown M, Omenn G, Hayes D, et al. Development and validation of sandwich ELISA microarrays with minimal assay interference. J Proteome Res. 2008;7:2406-14 pubmed publisher
	Biancotto A, Iglehart S, Lisco A, Vanpouille C, Grivel J, Lurain N, et al. Upregulation of human cytomegalovirus by HIV type 1 in human lymphoid tissue ex vivo. AIDS Res Hum Retroviruses. 2008;24:453-62 pubmed publisher
	Weindl G, Naglik J, Kaesler S, Biedermann T, Hube B, Korting H, et al. Human epithelial cells establish direct antifungal defense through TLR4-mediated signaling. J Clin Invest. 2007;117:3664-72 pubmed
	Rao D, Tracey K, Pober J. IL-1alpha and IL-1beta are endogenous mediators linking cell injury to the adaptive alloimmune response. J Immunol. 2007;179:6536-46 pubmed
	Pfleger C, Schloot N, ter Veld F. Effect of serum content and diluent selection on assay sensitivity and signal intensity in multiplex bead-based immunoassays. J Immunol Methods. 2008;329:214-8 pubmed
	Todd J, Freese B, Lu A, Held D, Morey J, Livingston R, et al. Ultrasensitive flow-based immunoassays using single-molecule counting. Clin Chem. 2007;53:1990-5 pubmed
	Biancotto A, Grivel J, Iglehart S, Vanpouille C, Lisco A, Sieg S, et al. Abnormal activation and cytokine spectra in lymph nodes of people chronically infected with HIV-1. Blood. 2007;109:4272-9 pubmed
	Lee K, Ho S, Lin H, Lin S, Liu C, Huang C, et al. Neutrophil-derived elastase induces TGF-beta1 secretion in human airway smooth muscle via NF-kappaB pathway. Am J Respir Cell Mol Biol. 2006;35:407-14 pubmed

product information

brand :

R&D Systems

master code :

MAB200

SKU :

MAB200-100

product name :

Human IL-1 alpha/IL-1F1 Antibody

description :

The Human IL-1 alpha/IL-1F1 Antibody from R&D Systems is a mouse monoclonal antibody to IL-1 alpha/IL-1F1. This antibody reacts with human. The Human IL-1 alpha/IL-1F1 Antibody has been validated for the following applications: Western Blot, Neutralization, Immunocytochemistry, ELISA Capture (Matched Antibody Pair).

target :

IL-1 alpha/IL-1F1

category :

Primary Antibodies

unit size :

100 ug (also 25 ug, 500 ug)

buffer :

Lyophilized from a 0.2 µm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied as a 0.2 µm filtered solution in PBS.

clonality :

Monoclonal

clone :

4414

concentration :

LYOPH

conjugate :

Unconjugated

host :

Mouse

immunogen :

E. coli -derived recombinant human IL-1 alpha/IL-1F1, Ser113-Ala271, Accession # P01583

isotype :

IgG2a

purity :

Protein A or G purified from hybridoma culture supernatant

species :

Human

specificity :

Detects human IL-1 alpha/IL-1F1 in ELISAs and Western blots. In ELISAs, this antibody does not cross-react with recombinant human (rh) IL-1 beta , -2, -3, -4, -5, -6, -7, -8, -9, -10, -11, -12, -13, rmIL-1 alpha , -1 beta , -3, -4, -5, -6, -7, -9, or -13.

gene symbol :

IL1A

endotoxin note :

<0.10 EU per 1 µg of the antibody by the LAL method.

catalog number base :

MAB200

accessionNumbers :

P01583

applications :

Western Blot, Neutralization, Immunocytochemistry, ELISA Capture (Matched Antibody Pair)

2020 USD :

339

2021 USD :

369 USD

alt names :

BAF, Hematopoietin-1, IL1, IL1 alpha, IL-1 alpha, IL1A, IL-1A, IL1-ALPHA, IL1F1, IL-1F1, IL1F1hematopoietin-1, interleukin 1, alpha, interleukin-1 alpha, LAF, LEM, preinterleukin 1 alpha, pro-interleukin-1-alpha

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 6 months, -20 to -70 °C under sterile conditions after reconstitution.