product summary
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company name :
R&D Systems
product type :
antibody
product name :
Human PKR Antibody
catalog :
MAB1980
quantity :
100 ug (also 25 ug)
price :
479 USD
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
HL71/10
reactivity :
human
application :
western blot, immunocytochemistry, immunoprecipitation
more info or order :
R&D Systems product webpage
citations: 9
Reference
Burnett S, Culver A, Simon T, Rowson T, Frederick K, Palmer K, et al. A frameshift mutation in the murine Prkra gene causes dystonia and exhibits abnormal cerebellar development and reduced eIF2α phosphorylation. bioRxiv. 2024;: pubmed publisher
Ukhueduan B, Chukwurah E, Patel R. Regulation of PKR activation and apoptosis during oxidative stress by TRBP phosphorylation. Int J Biochem Cell Biol. 2021;137:106030 pubmed publisher
Kuipers D, Mandemakers W, Lu C, Olgiati S, Breedveld G, Fevga C, et al. EIF2AK2 Missense Variants Associated with Early Onset Generalized Dystonia. Ann Neurol. 2021;89:485-497 pubmed publisher
Nishikawa S, Itoh Y, Tokugawa M, Inoue Y, Nakashima K, Hori Y, et al. Kurarinone from Sophora Flavescens Roots Triggers ATF4 Activation and Cytostatic Effects Through PERK Phosphorylation. Molecules. 2019;24: pubmed publisher
Golec E, Lind L, Qayyum M, Blom A, King B. The Noncoding RNA nc886 Regulates PKR Signaling and Cytokine Production in Human Cells. J Immunol. 2019;202:131-141 pubmed publisher
Shelkovnikova T, Kukharsky M, An H, Dimasi P, Alexeeva S, Shabir O, et al. Protective paraspeckle hyper-assembly downstream of TDP-43 loss of function in amyotrophic lateral sclerosis. Mol Neurodegener. 2018;13:30 pubmed publisher
Chukwurah E, Patel R. Stress-induced TRBP phosphorylation enhances its interaction with PKR to regulate cellular survival. Sci Rep. 2018;8:1020 pubmed publisher
Vaughn L, Bragg D, Sharma N, Camargos S, Cardoso F, Patel R. Altered activation of protein kinase PKR and enhanced apoptosis in dystonia cells carrying a mutation in PKR activator protein PACT. J Biol Chem. 2015;290:22543-57 pubmed publisher
Singh M, Fowlkes V, Handy I, Patel C, Patel R. Essential role of PACT-mediated PKR activation in tunicamycin-induced apoptosis. J Mol Biol. 2009;385:457-68 pubmed publisher
product information
brand :
R&D Systems
catalog number base :
MAB1980
SKU :
MAB1980
product name :
Human PKR Antibody
units size :
100 ug (also 25 ug)
description :
The Human PKR Antibody from R&D Systems is a mouse monoclonal antibody to PKR. This antibody reacts with human. The Human PKR Antibody has been validated for the following applications: Immunoprecipitation,Western Blot,Simple Western,Immunocytochemistry.
target :
PKR
category :
Primary Antibodies
buffer :
Lyophilized from a 0.2 µm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.
clonality :
Monoclonal
clone :
HL71/10
concentration :
LYOPH
conjugate :
Unconjugated
all_available conjugate :
Unconjugated
host :
Mouse
immunogen :
Protein kinase fraction from interferon-treated Daudi human Burkitt's lymphoma cell line. Laurent, A.G. et al . (1985) Proc. Natl. Acad. Sci. 82 :4341.,
isotype :
IgG1
purity :
Protein A or G purified from hybridoma culture supernatant
species :
Human
specificity :
Detects human PKR in Western blots.
gene symbol :
PRKRA
top caption :
Detection of Human PKR antibody by Western Blot.
applications :
Immunoprecipitation,Western Blot,Simple Western,Immunocytochemistry
USD :
479 USD
alt names :
double stranded RNA activated protein kinase, EC 2.7.11.1, eIF-2A protein kinase 2, EIF2AK1, EIF2AK2, eukaryotic translation initiation factor 2-alpha kinase 2P1/eIF-2A protein kinase, interferon-induced, double-stranded RNA-activated protein kinase, interferon-inducible double stranded RNA dependent, interferon-inducible elF2alpha kinase, Interferon-inducible RNA-dependent protein kinase, P68 Kinase, PKRp68 kinase, PPP1R83, PRKR, PRKRMGC126524, Protein Kinase R, Protein kinase RNA-activated
storage :
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 6 months, -20 to -70 °C under sterile conditions after reconstitution.
more info or order :
R&D Systems product webpage
company information
R&D Systems
614 McKinley Place N.E.
Minneapolis, MN 55413
info@RnDSystems.com
https://www.rndsystems.com
800 343-7475
headquarters: USA
R&D Systems develops and manufactures high-quality proteins and serves as a world leader in immunoassays. R&D Systems also produces quality antibodies, antibody arrays, stem cell and cell culture products, and cell selection and detection products, serving the life science and diagnostics industry.